Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 34 for “"biophysical model"”.
-
Designer Exons Inform a Biophysical Model for Exon Definition
… a general "framework" equation was obtained modeling a necessary exon definition complex that enabled commitment to inclusion. This equation used rates for the formation and dissociation of this complex without elaborating on the details for how those rates came about. In the second stage, …
-
Biophysical model of core & matrix thalamocortical circuitry in rodents & primates
… Therefore, we created both a rodent and primate biophysical neural model of the core and matrix thalamocortical circuit. We found that the primate model was able to synchronize the network activity faster than the rodent model; primate TC relay neurons were less likely to sustain their activity, …
-
Biophysical Model of Retraction Motor Neurons and Their Modification by Operant Conditioning
… observed in B3 neurons. Using conductance-based modeling, this study examined OC-induced biophysical changes in B6 and B9. Neuron B4 makes an inhibitory chemical synaptic connection and is electrically coupled to B3, B6, and B9 retraction motor neurons. B4 excitability is reduced following OC. …
-
Statistical and biophysical modeling of binaural interaction in the lateral superior olive
… encoded remain uncertain. This work develops a biophysical model of the LSO network capable of simulating LSO responses to acoustically realistic stimuli. Our LSO network simulations demonstrate the extreme sensitivity of the LSO transient response to time delays caused by both ILDs and ITDs. …
-
Effect of Nanoscale Surface Structures on Microbe-Surface Interactions
… on nanostructured surfaces, we developed a biophysical model that calculates the total energy of adhered cells as a function of nanostructure size and spacing. Using this model, we predict the attachment density trend for Candida albicans on nanofiber-textured surfaces. The model can be …
-
A modeling study of the history-dependence of conduction delay in unmyelinated axons
… of three parts. In the first part, we build a biophysical model that includes several characterized ionic currents and the Na+/K+ pump in order to unmask the mechanisms underlying the history dependence of conduction delay. This model captures both the slow and fast timescale effects of …
-
Interactions between a changing agricultural landscape and regional trade
… agricultural trade. Chapter 2 develops a spatial model that extends von Thunen theory with a focus on land use specialization. Using numerical simulations, we illustrate how agricultural land use would be changed in different locations due to regional trade. Chapter 3 focuses on another …
-
Optical Coherence Tomography Angiography for Imaging and Analysis of the Choriocapillaris in Late Age-Related Macular Degeneration
… in conjunction with image analysis and disease modeling approaches. Key study results presented in this thesis include: (1) the development of an OCTA-based method for microvascular velocimetry that is compatible with clinical ophthalmic imaging; (2) the demonstration and quantification of …
-
THE IMPACT OF SEA-LEVEL RISE ON COASTAL WETLANDS USING IN-SITU MESOCOSM EXPERIMENTS, LANDSCAPE MODELING, AND TRADITIONAL ECOLOGICAL KNOWLEDGE MAPPING
… inundation. I applied a mechanistic landscape model to predict coastal wetland change impacted by sea-level rise in comparison to vulnerability assessments from traditional ecological knowledge (TEK). By integrating the biophysical model predictions with land-based, generational assessments, I …
-
System identification and modeling of primary electrosensory afferent response dynamics in the weakly electric fish Apteronotus leptorhynchus
… we have constructed a linear-nonlinear cascade model to describe the response properties of P-type afferents. We use parametric system identification technique to quantitatively characterize the response dynamics of the system. Comparisons of experimental data and model predictions to filtered …
-
Sensitivity and Memory in Physics and Biology
… dynamics of chromatin. I explore a simple biophysical model inspired by a class of these systems—involving the spreading of covalent modifications on chromatin—with the aim of uncovering qualitative features that can imbue them with the capacity for memory. We find that limitation of the …
-
Estimating the Contributions of Soil and Cover Crop Nitrogen Mineralization for Corn
… The objective of this work was to validate the biophysical model developed in Pennsylvania under Virginia conditions and to evaluate the decomposition rates of different surface-applied CC residues and the relationship between their chemical composition and decomposition rate. For the first …
-
Bacteria-Enabled Autonomous Drug Delivery Systems: Development, Characterization of Intratumoral Transport and Modeling
… and 3D invasion assays. Lastly, we developed a biophysical model of intratumoral transport of NanoBEADS based on the intratumoral penetration experimental results towards the theoretical evaluation of the drug transport profile following the administration of NanoBEADS.
-
Distribution, growth, and transport of larval fishes and implications for population dynamics
… collected in the field and the laboratory, with model simulations. In Chapter 2, analyses of field observations of ontogenetic vertical distributions of coral reef fish revealed a diversity of behaviors both between and within families. In Caribbean-wide particle-tracking simulations of …
-
Quantitative Analysis Demonstrates Most Transcription Factors Require only Simple Models of Specificity
… data is the complexity of the specificity model needed. This has important implications for both the characterization of specificity and for the prediction of the consequences of mutations. Structurally, TF-DNA interactions are complex with a wide variety of interactions between the protein …
-
Modeling for microbial communities with cross-feeding and predator-prey interactions
… interactions. In ecology, mathematical models have been proved effective in simulating diverse interactions and studying the stability of ecosystems under different interacting patterns and strengths. However, such a community-level understanding of microbial communities is still …
-
MRI techniques for quantitative and microstructure imaging
… requires the acquisition of multiple images for biophysical model fitting, which leads to long scan time that consequently causes low SNR, low spatial resolution, image artifacts and vulnerability to motion. This thesis aims at overcoming these challenges by developing novel MRI acquisition and …
-
A biophysical conductance-based model of neural spike timing and interspike interval correlations
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-12-04 without embargo terms
-
Measuring and Forecasting Environmental Conditions From the Perspective of Rocky Intertidal Organisms
… determined by tides, waves, and weather. Models that incorporate these parameters can be used to predict and understand the distributions of organisms on both local and latitudinal scales. Intertidal organisms oscillate between marine and terrestrial conditions, a phenomenon controlled by …
-
Dispersal and connectivity of northeastern atlantic patellid limpets: a multidisciplinary approach
… development, population genetics and physical modelling of dispersal. The reproductive cycles of four limpet species were assessed on the northern and central Portugese coast, to determine spawning periods. This information was incorporated into dispersal models. The results showed that P. …
Page 1 of 2