Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1281 for “"biophysical"”.
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Biophysical studies of TIMP-1
… of TIMP-l. The second was a series of biophysical studies of TIMP-l and a TIMP-l derived peptide. A monoclonal antibody affinity column was developed and used to purifY large quantities of human TIMP-l for further experiments. Two E.coli expression systems were studied to determine …
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Cutaneous Biophysical Characteristics of Melasma
… might have a significant impact on cutaneous biophysical characteristics. Objective: The cutaneous biophysical characteristics in melasma were investigated. Methods: A total of 16 Korean volunteers with melasma were enrolled. The melanin index/erythema index, stratum corneum (SC) hydration, …
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Biophysical Studies of Protein Assemblies
… as coupled folding and binding. What are the biophysical advantages and consequences of disorder in the context of these interactions? A common feature of IDPs is their sequence composition bias, with charged residues being often over-represented. It is therefore tempting to speculate that …
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Biophysical Mechanisms of Early Heart Morphogenesis
… of this dissertation is to elucidate some of the biophysical mechanisms that create and shape the early HT. Our work involves a combination of <italic>ex ovo</italic> experiments and computational modeling. Experiments were performed on embryonic chicken hearts, which are morphologically similar …
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Biophysical and Structural Studies of CNTNAP2
At synapses, cell adhesion molecules provide connection between the presynaptic and postsynaptic membranes through homophilic and heterophilic interactions promoting synapse development, function, and plasticity. The synaptic adhesion molecules contactin 2 (CNTN2), and contactin associated …
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Biophysical chemistry of lipopolysaccharide specific bacteriophages
Carbohydrate recognition is a ubiquitous principle underlying many fundamental biological processes like fertilization, embryogenesis and viral infections. But how carbohydrate specificity and affinity induce a molecular event is not well understood. One of these examples is bacteriophage P22 that …
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Biophysical dynamical priors in machine learning
… the relative efficacies of different levels of biophysical inductive bias. The approaches I introduce in Chapter 3 traverse from simple, black box dynamical biases to explicit biophysical priors encoded directly in the model. The resulting techniques are studied under the lens of the latent …
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Biophysical approaches to single-cell characterization
High-throughput single-cell RNA-seq (scRNA-seq) is used to describe complex tissues by characterizing transcriptional states of individual cells. Defining a cell’s position, both in regard to tissue margins and its social context, is essential for understanding the intrinsic and extrinsic variables …
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Biophysical interactions in the Iceland Basin
The Iceland Basin in the N. Atlantic has attracted considerable recent attention because the spring bloom in this region acts as the most powerful biological carbon pump anywhere in the world oceans. Furthermore, the link between primary productivity and herbivory by the calanoid copepod, Calanus …
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Quantum magnetic imaging for DNA biophysical measurements
… questions in biophysics and inspires further biophysical measurements and quantum sensor development.
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Quantum computing for biophysical and optimization problems
The remarkable progress of quantum technologies over recent years has driven significant efforts toward developing algorithms with applications to a wide range of research fields. Beyond fully quantum algorithms — whose efficacy remains constrained by technological limitations — hybrid …
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Biophysical Applications of Single Molecule Fluorescence Localization
Fluorescence single molecule localization has become a powerful tool for investigating problems in biological physics. However, there are numerous limitations on the types of measurements that can be made with typical instrument designs based on objective-type TIR and wide field CCD imaging. We …
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Functional dna: Biochemical/biophysical characterization & sensing applications
… of the 8-17 DNAzyme and involve biochemical and biophysical characterization of the 8-17 DNAzyme as well as characterization of a novel red Pb2+ species formed upon cleavage of a modified 8-17 DNAzyme. Determination of the enantiomeric ratio is important as many monetarily and functionally …
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Biophysical studies of chromatin folding and unfolding
Chromatin, the building material of chromosomes, is folded and unfolded by several levels, providing a physical basis of coordinated DNA functions in eukaryotic cells. Chromatin folding is started with a linear long string of nucleosomes, connected by segments of DNA called linker DNA. Further …
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Biophysical responses of lymphocytes to environmental stress
Cellular biophysical properties both reflect and influence cell state. These parameters represent the consequences of the interactions of multiple molecular events, and thus may reveal information otherwise obscured when measuring individual pathways in isolation. Previous work has demonstrated how …
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Biophysical specializations supporting efficiency in neural networks
… I will use the remarkable structural and biophysical diversity of the brain as an introduction into what it means for a system to be “brain-like.” This will lead us to a discussion of dendrites, the tree-like structures implicated at virtually every length scale of neural computation. …
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Biophysical modeling of hemodynamic-based neuroimaging techniques
Two different hemodynamic-based neuroimaging techniques were studied in this work. Near-Infrared Spectroscopy (NIRS) is a promising technique to measure cerebral hemodynamics in a clinical setting due to its potential for continuous monitoring. However, the presence of strong systemic interference …
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