Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"biopharmaceuticals"”.
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Quality by design for the downstream processing of biopharmaceuticals
… how it has been applied to the manufacture of biopharmaceuticals. Protein A chromatography is the most commonly used technique for the manufacture of monoclonal antibodies today. To make the results of this work widely applicable a QbD approach is developed to compare the suitability of …
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Engineering Medical Devices to Improve Oral Delivery of Biopharmaceuticals
The dynamic mechanics of the gastrointestinal (GI) tract, including gut contractions, variable pH, and degradative enzymes, significantly challenge the development of oral delivery systems for biologic drugs by compromising their reliable delivery and therapeutic efficacy. While recent advances in …
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Development of new tools for the production of plasmid DNA biopharmaceuticals
… tools for the production of plasmid DNA biopharmaceuticals. As one part of this thesis, we designed a 1-mL fed-batch microbioreactor with online monitoring and control of dissolved oxygen, pH, and temperature, as well as continuous monitoring of cell density. We used the microbioreactors …
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Understanding the drivers of value creation for biopharmaceuticals around the time of drug launch
The purpose of this research is to investigate potential strategic variables that executives at small to mid-sized biopharmaceutical companies should consider during the period of a drug launch. Bringing a product to market is a critical event for any biopharmaceutical company. It marks a major …
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Transport of proteins, biopharmaceuticals and small pharmaceutical compounds into normal and injured cartilage by Sangwon Byun.
… the uptake and binding of proteins and biopharmaceuticals in normal articular cartilage and have compared the results to those in cartilage subjected to mechanical injury and pro-inflammatory cytokines. We studied equilibrium partitioning and non-equilibrium transport into cartilage of …
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Mechanistic Insights into the Stabilisation of Biopharmaceuticals using Glycine Derivatives. The Effect of Glycine Derivatives on the Crystallisation, Physical Properties and Behaviour of Commonly used Excipients to Stabilise Antigens, Adjuvants and Proteins in the Solid State
This dissertation has focused on studying the effect of four glycine derivatives on the solid state properties of mannitol, glycine, and sucrose when freeze dried into blended mixtures. The primary goal was to assess their value for use in the stabilisation of vaccines in the solid state, by …
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Rheology of concentrated protein solutions and attractive colloidal dispersions
… facilitate the development and engineering of biopharmaceuticals. In general, viscosity of attractive colloidal dispersions increases with their concentration and attraction strength, and diverges at the gel point. In this thesis, we investigate the mechanism of enhanced viscosity of …
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Endogenous and chemical modifications of model proteins
… their biological roles and improve the range of biopharmaceuticals. To probe the biochemistry of endogenous glycosylation and to test the efficacy of novel synthetic modifications, tractable protein scaffolds are needed. Previously, members of the pancreatic-type ribonuclease (ptRNases) …
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Integrated microbioreactor arrays for high-throughput experimentation
… cells play an important role in producing biopharmaceuticals such as human insulin and human growth hormone, and other products such as amino acids and biopolymers. Because bioprocesses involve the complicated interaction between the genetics of the microorganisms and their chemical and …
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Baculovirus stability in serum-free lyophilized and wet storage conditions
… way to produce recombinant proteins for biopharmaceuticals. However baculovirus stocks are stored in subzero temperatures to maintain virus stability, and fetal bovine serum is commonly used in the storage solution. In an effort to lower transportation and storage costs, a storage …
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DEVELOPMENT OF PROTEIN-BASED ANTIFUNGALS
… Pattern β-glucan to develop Dectin-1 based biopharmaceuticals against the common fungal pathogen Candida albicans as a model for the use of PRR-PAMP natural affinity as a strategy against fungal infections.
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Commercial technology transfer optimization for drug substance process development
Commercial technology transfer for biopharmaceuticals is the process of transferring process and product knowledge between process development and manufacturing organizations to achieve product realization. This process often occurs before phase 3 of clinical trials, where speed and agility are …
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IoT at Amgen - Evaluating and Piloting Industry 4.0 Technology in Biomanufacturing
… a global leader in the production of life saving biopharmaceuticals, has previously supported IoT-based solutions to provide new capabilities within existing biomanufacturing practices. However, selecting and prioritizing potential IoT investments- especially given the mature wired instrumentation …
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Model-based Design and Control of Biopharmaceutical Manufacturing Processes
Biopharmaceuticals are products derived from biological organisms for treating or preventing diseases. The global sales of biopharmaceuticals have continually increased for many years and will continue to increase, as the pipeline of product candidates continues to grow. Recent trends in …
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A New Approach for Fast Processing of SPARQL Queries on RDF Quadruples
… extract knowledge in domains such as healthcare, biopharmaceuticals, defense, and intelligence. Popular approaches like RDF-3X perform poorly on RDF datasets containing billions of triples when the queries are large and complex. This is because of the large number of join operations that must be …
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The impact of variation in freezing and thawing process parameters on the critical quality attributes of a monoclonal antibody
Therapeutic proteins or biopharmaceuticals have been playing an ever-increasing role in the treatment of human diseases over last 40 years. One of the main challenges with manufacture of these proteins is the stabilization of both the finished product and its processing intermediates during …
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Tissue engineering of co-cultured skin substitutes using biocomposite membranes based on collagen and polycaprolactone
… for controlled presentation and release of biopharmaceuticals such as growth factors. Good compatibility of all biocomposite groups was proven by interaction with 3T3 fibroblasts, normal human epidermal keratinocytes (NHEK), and primary human epidermal keratinocytes (PHEK) and dermal …
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The co-modulation of apoptosis and the cell cycle
… on mammalian cell culture for the production of biopharmaceuticals; therefore research aimed at improving the characteristics of the cell-lines being used for recombinant protein production is essential. In this study I have examined the hypothesis that the creation of a CHO cell-line in which …
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Molecular, Genetic, and Process Approaches for Improving Secreted Pharmaceutical Protein Quality in Komagataella phaffii
… antibodies, the leading class of protein biopharmaceuticals by both sales and innovation. Firstly, we demonstrated significant quality improvements through molecular sequence engineering of aglycosylated monoclonal antibody backbones. By making informed, conservative mutations to two or …
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