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Showing 1 to 1 of 1 for “"bioorthogonal tethering"”.
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Bioorthogonal Tethering of Drug Fragments to Engineered G Protein-Coupled Receptors
… employing genetic code expansion (GCE) and bioorthogonal chemical reactions for tethering drug fragments adjacent to allosteric sites in GPCRs to increase their potency and enable fragment-based drug screening in cellular systems. C-C chemokine receptor 5 (CCR5) was selected as a model …