Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"bioorthogonal decaging"”.
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Tetrazine-Triggered Bioorthogonal Decaging Reactions for Prodrug Activation
Bioorthogonal decaging reactions have emerged as a promising strategy for the spatially and temporally controlled activation of proteins and drugs. The inverse electron-demand Diels-Alder (IEDDA) reaction between tetrazines and strained alkenes exhibits high reaction rates and selectivity and has …
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CHEMICAL BIOLOGY STRATEGIES FOR THE FORMATION AND CLEAVAGE OF CHEMICAL BONDS
… palladium species involved in palladium-assisted bioorthogonal reactions. In summary, the methods and findings presented in this thesis contribute to the portfolio of chemical transformation strategies available in the interdisciplinary field of chemical biology and provide new opportunities for …
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Metal Mediated Mechanisms of Drug Release
… be described research towards the development of bioorthogonal bond-cleavage reactions, and their applications in targeted drug delivery (Figure 1). The first project relates to the development of a palladium mediated bond-cleavage or “decaging” reaction which can cause a propargyl carbamate to …