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Showing 1 to 16 of 16 for “"bioorganic"”.
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Bioorganic activation of cytochrome P-450cam
The Cytochrome P-450 class of monoxygenases carry out a wide variety of hydroxylation, epoxidation and heteroatom oxidation reactions. The cytochrome P-450cam enzyme from P. putida has been widely studied as a model for other P-450s due to the availability of a high resolution X-ray crystal …
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Bioorganic Studies Related to Coenzymes and Nucleic Acids
Made available in DSpace on 2014-12-10T23:01:28Z (GMT). No. of bitstreams: 1 7310047.pdf: 4655883 bytes, checksum: 280d0683f091773f276b3930f3e468c6 (MD5) Previous issue date: 1972
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Experimental and Computational Studies in Bioorganic and Synthetic Organic Chemistry
Cationâ Ï interaction is an important determinant in protein structure and function. Among the three proteinogenic aromatic amino acids, tryptophan (Trp) is the strongest cationâ Ï donor. We reported the asymmetric syntheses of tryptophan regioisomers in which the amino acid side chain is attached …
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Aspects of bioorganic chemistry - a). Development of caffeine-aptamer for coffee decaffeination; b). Study of 1,8-naphthalimide derivatives as fluorescent probes; c). Encapsulation of DNA by silica nanoparticles
… in this thesis encompass three aspects of bioorganic chemistry: Caffeine- binding aptamers were sought to remove caffeine from coffee brew. Toward this goal, theophylline carboxylic acid and caffeine carboxylic acid were synthesized, and immobilized to ω-aminohexyl–agarose. The immobilized …
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New Aspects in the Pharmaceutical Analysis of Quinine and Some of Its Oxidation Products // Нови аспекти във фармацевтичния анализ на Quinine и някои негови продукти на окисление
… to the general knowledge of this class of bioorganic compounds. Additionally, the qualitative analysis is an element of the general identification analysis of each pharmacopoeial and pharmacologically significant representative. In this regard, the methods of qualitative alkaloid analysis …
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Aplikace substituovaných pyranonů v chemii dendralenů a totální syntéze přírodních látek
… Králové Department Department of Organic and Bioorganic Chemistry Candidate Mgr. Michal Kadaník Supervisor prof. RNDr. Milan Pour, Ph.D. Title of Doctoral Thesis Application of substituted pyranones in dendralene chemistry and total synthesis of natural compounds This thesis deals with the …
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Deoxyribozymes for peptide substrates: exploring the landscape of nucleophiles and electrophiles
… that have the ability to catalyze various bioorganic reactions are called deoxyribozymes. Deoxyribozymes do not occur naturally and are identified using a combinatorial chemistry technique called in vitro selection. Since the discovery of the first artificial deoxyribozyme that catalyzes …
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Synthesis, Chemistry, Biological Evaluation And Structure-Activity Relationships Of Rac- And Chiral 6-Desmethyl-5Β –Hydroxy-D-Secoartemisinin And Analogs
… could not be true in all cases because clear bioorganic and biological evidence for the intermediacy of protein receptors exists. By separating two Mosher ester diastereomers of the title compound folloby saponification into the (3R, 5R, 5aR, 9aS) and (3S, 5S, 5aS, 9aR) enantiomeric alcohols. …
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Mass Spectrometry-Based Strategies for Biomolecular Structure Analysis: Steroid Metabolites Structures and Protein-Protein Interactions
… switched to biological science measuring large bioorganic molecules. Today, with the developing interest in metabolomics and proteomics, and ongoing improvement in MS-based techniques, mass spectrometry is extensively applied in the study of both small and large molecules.The research presented …
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Biocatálisis aplicada a la preparación enantioselectiva de heterociclos funcionalizados y compuestos con centros estereogénicos cuaternarios
… 694-698 A. Villar-Barro, R. Brieva, V. Gotor, Bioorganic & Medicinal Chemistry, 2014, 22, 5563-5568. Capítulo 3: Se lleva a cabo una síntesis regioselectiva de derivados 3-amino-4-hidroxipiperidínicos ortogonalmente protegidos, obteniéndose productos de interés por su posible aplicación en la …
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Spektroskopie der Neurotransmitter Tryptamin und Phenylethylamin
… substitution of molecules is a powerful tool in bioorganic and pharmaceutical applications to influence physiochemical and pharmacological properties. The isolated characterization in the gas phase allows to investigate a molecule free of any solvents but also the controlled stepwise solvation of …
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Isolation and Structure Elucidation of Cytotoxic Natural Products from the Rainforests of Madagascar and Suriname
As part of an ongoing investigation of new bioactive metabolites from rainforest flora, extracts from five different plants were determined to have interesting compounds that were new and/or cytotoxic. These phytochemicals were isolated by various separation techniques and then characterized by …
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Eine molekulare Fliegenfalle zur Erkennung von biologisch relevanten (poly)-anionischen Substraten
Im Rahmen dieser Arbeit konnte ein multivalenter Rezeptor auf Basis von Guanidiniocarbonylpyrrolen zur Komplexierung von biologisch relevanten (poly)- anionischen Substraten wie Citrat, Malat und Tatrat dargestellt werden. Der Rezeptor bindet Citrat selbst in Gegenwart eines 1000fachen Überschusses …
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The versatile use of Guanidiniocarbonylpyrroles : from self-assembly to peptide recognition
Die vorliegende Arbeit gliedert sich in zwei Themenschwerpunkte. Ein supramolekulares Projekt beinhaltete die Entwicklung von neuen flexiblen, selbst-aggregierenden Zwitterionen als Bausteine für supramolekulare Polymere. In einem zweiten bioorganischem Teil bestand das Ziel darin, Rezeptoren für …
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Developing novel systems for expression of intracellular membrane-bound human cytochrome P450 enzymes in baker’s yeast
… whole yeast cells, harbouring human CYPs, for bioorganic reactions. Chapter 7 describes the successful simultaneous co-production of two or three different human CYPs within the same cells. It is likely that two specific CYPs function, in tandem, on a substrate. There is also a necessity of …