Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 158 for “"biomolecule"”.
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Coarse-grained models of biomolecule dynamics and allostery
Recently, it has become increasingly accepted that thermal fluctuations take active part in functional tasks of biological molecules. We employ a set of coarse-grained models to investigate the mechanism of transmission of allosteric signal via spatial fluctuations. Our models are coarser than …
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Synthesis and Characterisation of Photoresponsive Azobenzene-Biomolecule Conjugates
… precursors, or dipolarophiles is described. Biomolecules bearing the complementary functionality are reported. The formation of isoxazole, triazole and ether linked biomolecule conjugates is demonstrated. Peptide conjugates have been prepared by cycloaddition in solution and on the solid …
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Controlling Plasmon Coupling in Biomolecule-Linked Nanoparticle Assemblies
… control of plasmon coupling is investigated in biomolecule-linked nanoparticle assemblies in two-particle, small cluster, and extended network formats. The relationship between structure and optical properties is explored through comparison of measured spectra with simulated spectra calculated …
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Gold Nanomaterial–Biomolecule Interactions: Influence of Size, Gold Nanomaterial–Biomolecule Interactions: Influence of Size, Surface Chemistry, and Environment Surface Chemistry, and Environment
… strongly depends on their interactions with biomolecules and their stability under physiological environments. This dissertation investigates the effect of nanoparticle size, ligand chemistry, proteins, and storage time on the behavior of gold nanoparticles (AuNPs) in biologically relevant …
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Particle-enhanced biomolecule detection using silicon photonic microring resonators
… measurements of proteins, as well as other biomolecules, in complex matrices. The following chapters present the work I have completed towards the development of particle-based detection schemes for use on the microring resonator platform. Chapter 2 details the initial attempts at detection …
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Enabling technologies for multiplexed biomolecule analysis and cell sorting
… and (3) perform rapid and accurate multiplexed biomolecule quantification using such particles. Bead-Patterned Hydrogels are a class of materials developed in this thesis that consist of microbeads precisely patterned in poly(ethylene glycol) (PEG) matrices. Using microfluidics and projection …
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Development of Polymer-Biomolecule Core-Shell Particles For Biomedical Applications
<p>Developing efficient strategies to introduce biomolecules around polymeric nanoparticles (NPs) is critical for targeted delivery of therapeutic or diagnostic agents. Although polymeric NPs have been well established, problems such as toxicity, stability, and immunoresistance remain potential …
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Improvement of the precorrected-FFT implementation of biomolecule electrostatics simulation
Thesis (M.Eng. and S.B.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2003.
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Deposition, crystallization and nanoindentation of substrate-bound biomolecule-assembled nanomaterials
The directed assembly of nanoscale components has the potential to generate novel macroscopic materials with specific hierarchically ordered structures and programmable physical and chemical properties. DNA is a particularly promising material to direct nanomaterial assembly, as its …
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An integrated membrane-based chromatographic process for biomolecule isolation and purification
Biomolecules obtained from fermentation and cell-culture processes are present in low concentrations in a complex medium/broth. For intracellular products, cells are first harvested. Subsequently, cell lysis and homogenization are undertaken to produce a homogenate. The biomolecules are next …
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DNA Walkers: Emerging Analytical Applications, Biomolecular-Nanomaterial Probes and Biomolecule Sensors
… of probing dynamic interactions occurring at the biomolecule-nanoparticle (bio-nano) interface. By monitoring dynamics of DNA walkers on spherical nucleic acid (SNA) tracks, we systematically investigated effects of varying interfacial factors, including intramolecular interactions, orientation, …
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Organic material-based, next-generation nanozyme for effective agricultural biomolecule sensing
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-05-01
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Model and analysis of MoS2 nanopore biomolecule detection via membrane current
… ions, charge carriers around the pore rim, and biomolecules. In combination with experimental study and molecular dynamics (MD) calculation, a comprehensive physical analysis of various resistive effects involved in the electronic detection of a single biomolecule in a nanopore of a MoS2 …
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On-chip multi-dimensional biomolecule separation using multi-layer microfabricated valves
… are described to achieve multi-dimensional biomolecule separation in a microfluidic channel. The new methods couple isoelectric focusing (IEF) with high ionic strength capillary electrophoresis (CE) by active micro valve control in a microchip. Several experiments demonstrating independent …
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Charge and temperature effects on biomolecule hydration: an experimental and computational investigation
The focus of this dissertation is on the role of charge and temperature on the structure of hydrated cluster ions. This is investigated using a combination of infrared photodissociation (IRPD) spectra and geometry and frequency calculations. The particular cluster ions examined here include …
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Extracting biological information from DNA-biomolecule interactions using machine learning and statistics
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-12-01
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The synthesis and characterisation of inorganic and organic luminophores suitable for biomolecule conjugation
… of these transition metal complexes to biomolecules has lead to more targeted and improved applications in medical diagnostics, photodynamic therapy, cellular imaging and pharmaceutical drug delivery. Chapters 3 & 4 detail the synthesis and photophysical characterisation of a series of …
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Development of a PDMS Based Micro Total Analysis System for Rapid Biomolecule Detection
… multi-purpose, impedance based detection of biomolecules. The major components of the micro total analysis system include a micropump, micromixer, magnetic separator and interdigitated electrodes for impedance detection. Three designs of pneumatically actuated PDMS based micropumps were …
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Computational modeling of protein-biomolecule interactions with application to mechanotransduction and antibody maturation
… of specific interactions between proteins and biomolecules. Therefore, understanding the molecular mechanisms influencing protein-biomolecule binding interactions is important both for fundamental knowledge and as a foundation for therapeutic applications and biotechnology. This thesis presents …
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