Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 37 for “"biomolecular interactions"”.
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Modeling Biomolecular Interactions with Generative Models
… challenge in biology. However, understanding biomolecular interactions, a critical problem for advancing drug discovery and biological research, remained unsolved. This thesis presents our research to redefine the machine learning approach to this problem, modeling structures with a new …
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Learning the language of biomolecular interactions
… primary functional unit of the cell, and their interactions drive cellular function. Interactions between proteins are responsible for a wide variety of functions raning from catalytic activity to cellular transport and signaling, and interactions between small molecules and proteins are the …
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Single molecule fluorescence studies of biomolecular interactions
… become standard approaches to study protein-DNA interactions. However, these techniques have largely been confined by limitations in assays to studying the interaction between simple DNA substrates and a single protein. During my PhD I developed several novel assays to study a long-standing …
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Nanoparticle probes for the study of biomolecular interactions
… is a growing requirement to be able to detect interactions between biological molecules to develop our understanding of disease expression and progression and for improvement of patient diagnosis in medical applications. One of the most effective ways this can be achieved is to label …
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MEMS-based temperature-dependent characterization of biomolecular interactions
Biomolecular interactions are of fundamental importance for a wide variety of biological processes. Temperature dependence is a ubiquitous effect for biomolecular interactions as most biological processes are thermally active. Understanding the temperature dependence of biomolecular interactions is …
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INVESTIGATION OF BIOMOLECULAR INTERACTIONS FOR DEVELOPMENT OF SENSORS AND DIAGNOSTICS
… Uncovering the molecular basis of these interactions is of great fundamental and applied importance. This research work focuses on understanding the interactions of several biomolecular recognition systems and processes that can provide fundamental information to aid in the rational …
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Biomolecular interactions and cellular effects of steroidal and metallosupramolecular metallodrugs
… Their cytotoxicity, cellular uptake and biomolecular interaction are investigated, showing that the coupling of the steroid confers activity to otherwise inactive complexes, modifying their DNA binding mode and cellular uptake and distribution. Chapter 3 explores the coupling of similar …
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Engineered biomolecular interactions with inorganic materials : sequence, binding, and assembly
Nanobiotechnology aims to exploit biomolecular recognition and self-assembly capabilities for integrating advanced materials into medicine and electronics. In particular, peptides have exhibited the ability to specifically bind to and/or control the synthesis of diverse inorganic and metallic …
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New tools derived from the solvatochromic 4-N,N-dimethylamino-1,8-naphthalimide fluorophore for the detection of biomolecular interactions
… behavior is driven by an intricate network of biomolecular interactions, which emerged through billions of years of evolution, is one of the great wonders of nature. Living cells must constantly assimilate vital information from the surrounding environment and respond appropriately. Such …
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The Development of High-Throughput and Miniaturized Differential Scanning Calorimeter for Thermodynamic Study of Bio-Molecules
Biomolecular interactions are fundamentally important for a wide variety of biological processes. Understanding the temperature dependence of biomolecular interactions is hence critical for applications in fundamental sciences and drug discovery. Micro-Electro-Mechanical Systems (MEMS) technology …
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Effects of Immobilization Matrices and Protein Orientation on Biomolecular Recognition at Solid-Liquid Interfaces
… the apparent kinetics and affinities of the biomolecular interactions at the solid-liquid interfaces were examined with a combination of several physical techniques. The recognition between cytochrome b5 and cytochrome c was chosen as the model system to both identify and quantify the forces …
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Protein Design at Library Scale
… vast sequence-structure spaces and evaluate biomolecular interactions, while experimental assays can now screen billions of variants in parallel. Yet, a key limitation remains: our current predictive models still struggle to capture the complex physical and dynamical factors that underlie …
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Development of High Pressure Surface Plasmon Resonance for the Study of Biosystems
… can be used to determine volume changes in biomolecular interactions is provided. The application of HP-SPR was extended to the use of commercially available sensor chips. We have shown that BIAcore(TM) SA chips maintain their surface binding functionality after pressure exposure and that …
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Efficient numerical algorithms for surface formulations of mathematical models for biomolecule analysis and design
… thesis discusses four contributions to modeling biomolecular interactions. First, the thesis presents an approach to allow accurate discretization of the most prevalent mathematical definitions of the biomolecule-solvent interface; also presented are a number of accurate techniques for …
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Virtual Screening of Multi-Target Agents by Combinatorial Machine Learning Methods
… As a joint effort, the Kinetics database of biomolecular interactions and the Therapeutic targets database were upgraded. They can offer informative data in multi-target drug discovery. I explored combinatorial support vector machines (COMBI-SVM) tool for virtual screening of multi-target …
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Discovering non-equilibrium mechanisms that regulatestructure and function of biomolecular condensates usingphase-field modeling
Biomolecular condensates are phase-separated assemblies in living cells that form through cooperative interactions between their constituents such as proteins and RNAs. They are emerging as important organizers of biochemistry in cells and are dysregulated in disease. Understanding the physical …
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Simulation of lipid membrane models at coarse-grained resolution Towards novel methodologies with improved capabilities
… an efficient Python library for characterizing biomolecular interactions from molecular dynamics trajectories; and ii- a new web portal for the Martini Force Field Initiative, built on an automatically maintained infrastructure and backend operations that support open collaboration in developing …
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Design and characterization of plasmonic nanoprobes and interparticle interactions for surface enhanced raman scattering and biomolecular detection
… nanoparticles upon interacting with the targeted biomolecular species. This thesis work focuses on investigating the interparticle interactions of chemcially-labled and bioconjugated gold and silver based nanoparticles and their influences on the plasmonic coupling for specctroscopic detection of …
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Antibody-based biosensor assays for the detection of zilpaterol and markers for prostate cancer
… optical biosensor capable of monitoring biomolecular interactions in 'real-time'). A zilpaterol-HSA conjugate was used to generate and characterise single chain antibody fragments. A combinatorial single chain (scFv) antibody phage display library was generated to zilpaterol. Splenomic …
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External cavity laser biosensor for label-free detection
… serve as a powerful detection tool to analyze biomolecular interactions, and have been widely used in pharmaceutical drug discovery and biochemical sensing. Desirable performance metrics for such sensors include high sensitivity and fine resolution, which are essential for achieving …
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