Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"biomolecular condensation"”.
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Biomolecular condensation of intrinsically disordered regions in P. falciparum and H. sapiens transcription factors
… unique mechanisms of transcriptional control. Biomolecular condensation, driven by intrinsically disordered regions (IDRs) in proteins, has emerged as a previously underappreciated mechanism of cellular compartmentalisation and regulation. The study of eukaryotic transcription has been …
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Equilibrium phase separation with many conserved order parameters - Analytical theory and applications in biomolecular condensation
In this PhD thesis I study the analytical theory of phase separation with many conserved order parameters, with a particular focus on applying new insights to understand membraneless organelles formed by proteins. There, the relevant order parameters are concentrations of various solute components, …
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The NTF2L Domain Is a Date Hub That Interacts with SLiMs to Regulate Assembly of Stress Granules
<p>Biomolecular condensation has been recognized as an important strategy for spatial or- ganization within cells. Biomolecules condense through interactions. When the sum and duration of collective interactions reach the percolation threshold, a system-spanning inter- action network is achieved, …
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Functional divergence of the RNA polymerase II transcription machinery in Plasmodium falciparum
… protein-protein interactions and the biomolecular condensation properties of these transcription factors, this study aimed to provide insight into the molecular mechanisms governing promoter recognition and the regulated assembly of the RNA polymerase II transcription initiation …
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Mechanical Manipulation of Eukaryotic Chromatin by DNA-Binding Proteins
… characterize the mechanical effects on DNA from biomolecular condensation, which has recently emerged as an important mechanism of gene regulation. In particular, I investigate how Sox2, which constitutes an important pioneer factor implicated in the maintenance of pluripotency, forms …
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The role of the RNA-binding protein FUS in axonal organisation and disease
The role of the RNA-binding protein FUS in axonal organisation and disease In this thesis, I discuss the role of the RNA-binding protein Fused in sarcoma (FUS) in axonal organisation and disease. FUS aggregates in forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), and …