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Showing 1 to 7 of 7 for “"biomolecular condensate"”.
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Phase transitions in soft matter: From colloidal suspensions to biomolecular condensate regulation
… In the context of multi-component protein condensates, we analyze the impact of protein valency and binding affinity on the molecular organization of condensates. We investigate how interfacial free energy acts as the driving force behind the organization of multilayered condensates and …
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The Effects of DEAD-box Helicase Activity on Biomolecular Condensate Structure and Dynamics
Biomolecular condensates are membraneless organelles which help spatiotemporally organize the biochemistry of the cytoplasm and nucleoplasm. These bodies are composed of specific proteins and RNA which self-associate to drive condensate formation. The strengths, timescales, and valence of the …
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The NTF2L Domain Is a Date Hub That Interacts with SLiMs to Regulate Assembly of Stress Granules
<p>Biomolecular condensation has been recognized as an important strategy for spatial or- ganization within cells. Biomolecules condense through interactions. When the sum and duration of collective interactions reach the percolation threshold, a system-spanning inter- action network is achieved, …
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Investigating Ageing of Neurodegenerative Disease Relevant Protein Condensates
… that can undergo the LLPS process and form biomolecular condensates. It has been demonstrated repeatedly that these condensates can play a wide range of cellular roles, from transcription to metabolism. In addition, an increasing amount of research is devoted to investigating aberrant …
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Quantitative Studies of Composition and Formation of Yeast P Bodies
… being enclosed by membranes--these are termed biomolecular condensates. Quantitative studies are lacking to mechanistically understand condensates within the complicated cellular environment. Toward this aim, I developed live cell imaging methods to quantitatively measure protein partitioning …
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Investigating the regulation of processing bodies in Drosophila melanogaster oocytes
… organelles to coordinate biological processes. Biomolecular condensates represent a broad class of non-membrane-bound organelles that assemble through phase separation. They exhibit diverse morphologies, compositions, material properties, and functions. A major subclass of biomolecular …
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RNA-MEDIATED PHASE SEPARATION OF 53BP1: CONNECTING CONDENSATE BIOPHYSICS TO DNA DAMAGE RESPONSE
Biomolecular condensates, also known as membraneless organelles, are intracellular compartments which can form via liquid-liquid phase separation (LLPS) where biochemical reactions concentrate within the cell. An example of such condensates are DNA damage response (DDR) foci, proteins and RNA …