Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"biomaterial systems"”.
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Polymeric materials for neovascularization
… strategies utilize a wide variety of polymeric systems, including hydrogels and biodegradable plastics, to deliver proangiogenic factors in a sophisticated manner to maintain a sustained proangiogenic environment. Despite some impressive results in rebuilding vascular networks, it is still a …
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Endogenous and exogenous control of polymers for spatiotemporally defined drug delivery
Polymeric ‘smart drug delivery systems’ respond to external and environmental stimuli to modulate drug release at the right time and in the right place. Here I present several polymer systems to overcome challenges in spatiotemporal control of drug delivery. First, a novel acid-labile liquid …
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Multifunctional bioactive polymers for the fabrication of tissue engineering scaffolds and the treatment of tissue ischemia
… thesis describes the development of advanced biomaterials for refined cell culture, encapsulation, and neovascularization, including: polymeric cross-linkers which tunes the elastic modulus and swelling ratio of hydrogels in a more independent manner (Chapter 2); fibronectin or fibronectin …
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Numerical Techniques for the Noninvasive Assessment of Material Properties and Stresses in Soft Biomaterials
… of finite displacements and strains in biomaterials by magnetic resonance imaging (MRI) may be shown to enable mathematical estimates of stress distributions and material properties within structures of the body such as articular cartilage or the intervertebral disc. Such methods will …
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Developing analytical tools for saccharides in condensed phases
… these molecules play in many biochemical and biomaterial systems. Moreover, the unusual response of these macromolecules to their environment allow them to play these often critical roles. This is particularly true for solvated carbohydrates. A knowledge of the molecular structure of …
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Synthetic biology tools for sensing and evolving microbes: CRISPR-diagnostics and transposon-mediated genome re-wiring
… sensors. Prokaryotic CRISPR-Cas adaptive immune systems evolved in part from ancestral transposon domains, and the inherent programmability of their RNA-guided nucleases has underpinned their use as specific and sensitive in vitro diagnostics. Here, I present our efforts to expand the use of …
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Interactions of environmentally-responsive nanoparticles with synthetic and biological membranes
… large variety of other synthetic and biological systems. This work will be essential in guiding the design of novel biomaterial systems for bioimaging, biosensing, and drug delivery applications and provides significant physical insight into behavior at the cell surface.
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Engineered microsystems and their application in the culture and characterization of three-dimensional (3D) breast tumor models
Microsystems are a broad category of engineered technologies in the micro and nano scale that have a diverse range of applications. They are emerging as a powerful tool in the field of biomedical research, drug discovery, as well as clinical diagnostics and prognostics, especially with regards to …
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Design of Biomaterials toward Endogenous Skeletal Tissue Repair
… tissue repair. In this dissertation, I explore biomaterials that are low-risk, cost-effective, and capable of leveraging endogenous healing mechanisms to promote skeletal tissue health. </p><p>Adenosine, a nucleoside ubiquitously present in the human body, is a potent pro-healing small molecule. …
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Collagen-Glycosaminoglycan Scaffold Systems to Assess HL-1 Cardiomyocyte Beating and Alignment
… thesis discusses the development of scaffold systems to examine the alignment and beating potential of HL-1 cardiomyoctyes in a 3D environment. Collagen-glycosaminoglycan scaffolds have been used extensively to probe the behavior of mature cells in vitro, but have not yet been designed for …
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Biodegradable Polymeric Biomaterials in Different Forms for Long-acting Contraception and Drug Delivery to the Eye and Brain
… decades, biodegradable polymeric drug delivery systems have emerged as promising candidates to solve the challenges of poor solubility, low permeability and sustained release owing to the advantages of biocompatibility, versatility, and tunable drug release. Polyesters and polysaccharides are …