Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"biomarkers of exposure"”.
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DNA adducts as molecular biomarkers of exposure to benzo(a)pyrene
Thesis (Ph. D.)--Massachusetts Institute of Technology, Division of Toxicology, 1997.
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E-Cigarettes: Biomarkers of Exposure and the Development and Validation of a Research Toolkit
… is limited research on the potential effects of regular ENDS use on health. Moreover, little is known about ENDS dependence and studies are often limited by a lack of validated research tools. Current measures of ENDS dependence are adapted from cigarette dependence questionnaires and do not …
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From Source to Surveillance: An Assessment of Liquid Elemental Mercury Mobilization in Soil, Downstream Reactivity, and Biomarkers of Exposure
… the environment. One understudied form is that of liquid elemental mercury (Hg0L), a dense non-aqueous phase liquid which, upon release to the environment, can persist in soil for decades. Over time, this residual Hg0L is gradually released to groundwater and eventually surface water, serving as …
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Evaluation of Metabolic Endpoints for Use as Biomarkers of Exposure to Environmental Estrogens and in Bioassays of Their Activity
… complement C3 can serve as sensitive indicators of estrogenicity. Additionally, angiotensinogen has the potential to be a biomarker of exposure to estrogenic compounds because its measurement only requires a blood sample, while providing a sensitive biochemical endpoint to supplement the …
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ASSESSMENT OF POLYCYCLIC AROMATIC HYDROCARBON BIOAVAILABILITY FROM SOIL USING THE JUVENILE SWINE MODEL
… from soil, and thus affect PAH bioavailability of ingested soil. Risk assessment of PAHs in soil generally assumes equal bioavailability of PAHs ingested in soil compared to PAHs ingested in reference dose media, leading to environmental cleanup guidelines that are potentially too conservative. …
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Sviluppo di tecniche di analisi ifenate per la quantificazione di biomarcatori di esposizione a tossici ambientali: gli acidi mercapturici
… (HBM) is an ideal tool for evaluating toxicant exposure in health risk assessment. Chemical substances or their metabolites related to environmental pollutants can be detected as biomarkers of exposure using a wide variety of biological fluids. Individual exposure to aromatic hydrocarbon …
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Impact of Reconstructed Wetlands on the Tree Swallow (Tachycineta bicolor)
… to evaluate the bioavailability and effect of contaminants to terrestrial life at reconstructed wetlands, Kingman Lake and Kenilworth Marsh, on the Anacostia River. Nesting success, survival, growth and developmental parameters were recorded and compared to an established reference location. …
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Protein Biomarkers of Ionizing Radiation and Standardization by MALDI MS/MS and Quantification
The overall objective of this work was to look for proteins that are up- or down-regulated following exposure to whole-body ionizing radiation (IR). The objective is to use these proteins as potential biomarkers of exposure to ionizing radiation of 2 Gy or greater which is the tolerance level for …
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Effects of embryonic exposure to androgen-active endocrine disrupting chemicals in Japanese quail
… production, secretion, action, and elimination of endogenous hormones. EDCs have been shown to be responsible for disrupting development, reproduction, immune function, behavior, and all other life functions mediated by hormones. In the environment, organisms are exposed to many different types …
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Assessing the Role of Dietary Polyamines on the Continuum of Colorectal Carcinoma
… and development. Pharmacological suppression of polyamine biosynthesis, by difluoromethylornithine, and inflammation, via sulindac, has demonstrated ~70% efficacy in preventing premalignant colorectal adenomas (CRA) in a clinical trial; however, high polyamine intakes mitigated this …
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Detection of Biological Effects of Environmental Pollutants of the Kafue River on the Kafue Lechwe (KOBUS LECHE KAFUENESIS)by Characterization of Selected Biomarkers
A lot of research in ecotoxicology is currently focused on identifying and developing suitable biomarkers for use in assessing environmental pollution. Thus this study was aimed at assessing the potential of Cytochrome P450 1A1 (CYP 1A1), Cytochrome P450 3A (CYP 3A) and Metallothionein1 (MT 1) as …
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Exposure to Phthalate Mixtures and Inner-City Pediatric Allergic Disease and Airway Inflammation
… population-based studies indicating widespread exposure. Prior epidemiologic studies have associated vinyl flooring, a proxy for phthalate exposure, or house dust concentrations of phthalates with eczema and asthma in children. However, these studies lack adequate exposure measurements, …
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Development and Application of Non-Traditional Vertebrate Models to Investigate Terrestrial Ecological Risk to 2,46-Trinitrotoluene Exposure
… interested parties (e.g., the U.S. Army Corps of Engineers, and the Tri-Service Ecological Risk Assessment Working Group). Interpretation of these and other guidance has been variable, often resulting in conflicting opinions on how best to address the question of ecological risk to receptors …
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Evaluation of Exposures to Diesel Particulate Matter Utilizing Ambient Air Monitoring and Urinary Biomarkers Among Pedestrian Commuters who Cross the U.S.-Mexico Border at San Ysidro, CA.
… border northbound at the San Ysidro, CA Port of Entry ("Border Commuters") may be at an increased risk of experiencing elevated traffic-related air pollution, including diesel exhaust (DE). DE exposure has been associated with numerous adverse health effects, particularly cardiovascular and …
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A systems-level analysis of dynamic reprogramming of RNA modifications in the translational control of cellular responses
… (tRNA) and ribosomal RNAs (rRNA) are comprised of more than 100 enzyme-catalyzed modifications, with about 20-35 found in any one organism. Many of these modifications are highly conserved in all domains of life, which suggests important biological roles for RNA modifications in cell physiology. …
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Biomarkers of Human Exposure and Effect to Petrogenic Polycyclic Aromatic Hydrocarbons
Safety of seafood harvested from the Gulf of Mexico has been a primary concern since the 2010 Deepwater Horizon (DWH) oil spill. Petrogenic polycyclic aromatic hydrocarbons (PAHs) found in crude oil have the potential to bioaccumulate in seafood and render consumers vulnerable to adverse health …