Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"biomarker expression"”.
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The Relationship Between Axonal Injury, Biomarker Expression And Mechanical Response In A Rodent Head Impact Acceleration Model
… injury predictors for TAI and identify potential biomarkers to evaluate TAI.</p> <p>In this dissertation, a modified Marmarou impact acceleration injury model was developed to allow the monitoring of velocity of the impactor and characterization of head kinematics during impact. The rat head …
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An Investigation Of The Relationship Between Axonal Injury, Biomarker Expression And Mechanical Response In A Rodent Head Impact Acceleration Model
… injury predictors for TAI and identify potential biomarkers to evaluate TAI.</p> <p>In this dissertation, a modified Marmarou impact acceleration injury model was developed to allow the monitoring of velocity of the impactor and characterization of head kinematics during impact. The rat head …
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Development and Evaluation of Approaches for Quantitative Optical Molecular Imaging of Neoplasia
… first approach focuses on widefield imaging of biomarkers near the tissue surface for early detection applications; this approach is demonstrated in freshly resected oral tissue. Most oral cancers are not detected until the disease has spread, but topical application of targeted imaging agents …
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Modern Staging in Primary Breast Cancer-aspects of micrometastatic disease in bone marrow and molecular profiles in lymph node metastases
… locations, to analyse the distribution of biomarkers and relate them to the prognosis for individual patients. A relationship has been recognised between the presence of disseminated tumour cells (DTCs) in bone marrow and poor prognosis in several studies, but the method of DTC detection …
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Integrated multiparametric deep spatial phenotyping of mouse models of lung adenocarcinoma
… and algorithms that use high dimensional biomarker imaging data to predict features of tumor tissues taken from a genetically engineered mouse model (GEMM) of lung adenocarcinoma. I extracted biomarker expression levels and morphological, textural, and spatial motifs of single cells from …
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Development of Electrochemical Immunosensor for Oral Cancer: Initial Outcome
… immunosensor targeting the S100A7 protein, a biomarker associated with OSCC risk. The biosensor's sensitivity and specificity were assessed across a range of clinically relevant concentrations in artificial serum and artificial saliva, simulating different stages of the disease. Additionally, …
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Modulation of human adipose-derived stem cells and dermal fibroblasts in co-cultures by activation of the IL-6 trans-signalling pathway via the soluble IL-6Rα receptor
… cytokine levels (TGFβ1, TGFβ3 and VEGF) and biomarker expression (TGF β1RII, SMAD2/3, SMAD 1/5/9 and SMA) were quantitated. Although both cell types secreted IL-6, ADSC basal levels were 100-fold that of DF. Both cell types expressed CD130 (gp130) signalling transductor but were negative for …
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Engineering and optimizing physiological cell isolation via the secondary anchor targeted cell release system
… individualized resistances and differences in biomarker expression on cells. Quantification of these biomarkers, then, would allow a methodology for designing personalized treatments and regimens that the patients would no longer be resistant to. However, techniques designed to purify or …
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Exploring the potential for biomarkers to aid forensic diagnosis of traumatic brain injury (TBI) – a systematic literature review and meta-analysis
… treatment, and cause of death determination. Biomarkers could offer potential insight. Proteins involved in neuroinflammation, such as systemic inflammatory biomarkers interleukin (IL)-1β, IL-6, and IL-10 and astroglia-associated biomarkers S100 Calcium-Binding Protein B (S100β) and Glial …
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Sex-Differences in Early-Onset Alzheimer's Disease
… sex and then by APOE ε4 carrier status. Imaging biomarkers were compared across strata, and voxel-wise multiple linear regressions generated statistical maps of gray matter density, amyloid, and tau PET burden. Chapter 3 analyses evaluated the impact of sex and APOE ε4 on plasma and cerebrospinal …
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Long-term expansion, genomic stability, in vivo safety and immunogenicity of adult human pancreas organoids
… in culture maintain their ductal morphology and biomarker expression of the primary tissue while they can also be expanded from tissue with underlying disease such as type 2 diabetes (T2D). This project further demonstrates that hPOs maintain stable chromosomal numbers following long-term in …
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Nuclear and Molecular Imaging Modalities for Predicting Calcific Aortic Valve Disease Progression in Animal Models
… need for earlier detection using predictive biomarkers that will allow for preventative intervention as opposed to post-symptomatic disease treatment or management. Namely, one target of particular interest is the expression of matrix metalloproteinases (MMPs) (specifically MMP-1, -2, and -9) …
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Exploring the effect of peri-operative inflammation on systemic and local breast cancer biomarkers
… inflammation on local and systemic biomarker expression. Hypothesis The peri-operative period can alter local and systemic mediators of breast cancer inflammation and influence circulating tumour DNA (ctDNA)release which may predict clinical and oncological outcomes. Aims 1. To …
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Imaging Post-Infarct Myocardial Inflammation with ⁶⁸Ga-DOTATATE PET/MRI and insights into COVID-19 associated myocardial injury
… well as to identify potential systemic and blood biomarker correlates of myocardial <sup>68</sup>Ga-DOTATATE PET signal. Methods: In a prospective observational cohort study, participants with recent MI underwent hybrid <sup>68</sup>Ga-DOTATATE PET/MRI within 2 weeks of infarction (t<sub>0</sub>), …