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Showing 1 to 19 of 19 for “"biology and genetics"”.
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An investigation of the molecular biology and genetics of Witches' Broom disease of Protea cynaroides
An investigation was undertaken into the biology and genetics of Witches' Broom disease on Protea cynaroides. The investigation was approached in two ways: firstly, from a physiological and pathological angle and secondly at the genetic level. As very little is known about the causes of Witches' …
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New era in the tratment of schizophrenia
… which can further be divided into positive and negative symptoms.With the advancement in various disciplines in the last century (such as: biochemistry, cell biology and genetics), the pharmacotherapy of this disorder has been continuously developing.
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A computational and experimental study of HER2-signaling effects on cellular migration and proliferation
… cells that interpret extracellular information and respond with such behavior as migration, proliferation, apoptosis, or differentiation. Thirty years of research in the related fields of biochemistry, molecular biology, and genetics have demonstrated that, in most cases, the cellular …
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Genetic structure and inversions in the Lake Malawi cichlid radiation
… underlying evolutionary processes of adaptation and speciation. The modern synthesis unified evolutionary biology and genetics, fundamentally reorienting life sciences. Recent advances in DNA sequencing have enabled evolutionary research to consider entire genomes, an unprecedented opportunity to …
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Characterization of Extracellular Proteolytic Activity From Prevotella Ruminicola and Streptococcus Bovis
The hypothesis of the study was that by isolating and characterizing proteinases from two of the predominant bacterial species in the rumen, Prevotella ruminicola and Streptococcus bovis, the understanding of the breakdown of dietary N in the rumen would be improved. Studies of how Prevotella …
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Gpi-Anchored Proteins In Ciliated Protozoa: From Ca++ Signaling To Mitochondrial Extrusion
… important models for the study of cell biology and genetics, most notably, Tetrahymena and Paramecium. One of the characteristic features of ciliates is their extensive cell surface comprised of plasma and ciliary membranes enriched in GPI-anchored proteins known as immobilization …
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Annotation and comparative analysis of fungal genomes: a hitchhiker's guide to genomics
… 98AG31, Puccinia graminis, Pichia pastoris GS115 and Candida bombicola, as well as the one of the haptophyte Emiliania huxleyi CCMP1516. These species are important organisms in many aspects, for instance: L. bicolor and G. intraradices are symbiotic fungi growing associate with trees and present …
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Molecular and genetic characterization of spinocerebellar ataxia type 5 (SCA5)
… 11 using an 11-generation American kindred, and was later refined to 11q13. Using a multifaceted mapping approach, which involved screening for expansion mutations, searching for haplotype conservation and sequencing, we discovered β-III spectrin (SPTBN2) mutations cause SCA5 in the American …
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Development of a chemical biology approach for glycoprotein discovery in Caenorhabditis elegans reveals glycosylated isoforms of multiple proteins with mitochondrial function
… is critical for cellular physiology and organism health. But understanding the cellular pathways that produce glycoproteins and the functional roles these glycoproteins play within the cell depends on having an adequate quiver of experimental approaches available. Together with my …
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Flows inside cells: From natural cytoplasmic streaming to microfluidic systems
… techniques for inducing cytoplasmic flows and controlling micron-sized particles. First, we consider cytoplasmic streaming observed during cell division, specifically in meiosis II mouse oocytes (developing egg cells) awaiting fertilisation. Inside the oocyte, the spindle, which is the …
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A biochemical and molecular analysis of functional differences between dystrophin and utrophin
… DMD become wheelchair bound in their early teens and succumb to fatal cardiac and/or respiratory failure in their mid-twenties to early thirties. There is currently no effective or widely available treatment for DMD beyond ventilatory support and the use of corticosteroids. Many therapies for …
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Activin signaling promotes the competence of the prothoracic gland during Drosophila metamorphosis
… hormone ecdysone produced by the prothoracic gland. However, the molecular mechanisms that control production of the ecdysone titer are not completely understood. Here we show that blocking Activin signaling in Drosophila prothoracic gland causes developmental arrest prior to metamorphosis. This …
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Oncogenic roles of RAS in acute myeloid leukemia cooperated with Mll-AF9.
… including bone marrow-derived mast cells (BMMC) and CD34 positive hematopoietic progenitor cells (HPC) as well as myeloid and lymphoid lineages by live mouse imaging and relative light unit measurement before or after treating Vav-tTA ; TRE -luciferase co-transgenic mice with doxycycline (Dox). …
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Proliferation and differentiation of progenitor cells in the spinal cord of adult macaque monkeys // Пролиферация и диференциация на прогениторни клетки в гръбначен мозък на възрастни примати
Неврогенезата в централната нервна система е изключително актуален проблем. Разглеждаме възрастовата неврогенеза у приматите. Установяваме количеството и фенотипа на пролифериращите клетки и проследяваме тяхната дългосрочна съдба в интактен гръбначен мозък на полово зрели маймуни с оглед …
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Long-term dispensation and molecular control of endogenous progenitor cells in adult primate telencephalon // Дългосрочна съдба и молекулен контрол на ендогенни прогениторни клетки в краен мозък на възрастни примати
Ние приложихме модел на временна обща мозъчна исхемия на възрастни маймуни (макаки) чрез обратимо прекъсване на мозъчния кръвоток. De novo генерирани клетки в исхемични или контролни субекти бяха белязани с bromodeoxyuridine (BrdU), индикатор за ДНК синтеза. Впоследствие, ние изследвахме …
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Maternal Biochemical Screening as a Method for Prenatal Genetic Prophylaxis /// Майчин биохимичен скрининг като метод за пренатална генетична профилактика
Майчин биохимичен скрининг като метод за пренатална генетична профилактика цели навременно осигуряване на максимално точна индивидуална оценка на риска за най-честите и клинично значими анeуплоидии при фетуса. Касае социално значими заболявания асоциирани с тежка клинична картина и/или намален …
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Expression of Cyclon/CCDC86 Gene in Cells of the Immune and Nervous Systems in Patients with Schizophrenia /// Експресия на гена Cyclon/CCDC86 в клетки на имунна и нервна системи при пациенти с шизофрения
Шизофренията е тежко социалнозначимо заболяване, засягащо около 1% от световното население, без ефективно лечение. Основна причина за това е хетерогенността на заболяването (група от поне 8 заболявания, „шизофрении”), като вероятно в различните групи има различна етиология и патогенеза и съответно …
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Two Problems in Computational Genomics
… genomics. The first is whole genome alignment and the second is inferring horizontal gene transfer using posets. We define these two problems and present algorithmic approaches for solving them. For the whole genome alignment, we define alignment graphs for representing different evolutionary …