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Showing 1 to 20 of 22 for “"biologically active molecules"”.
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Biologically active molecules from marine microalgae
Diatoms are unicellular photosynthetic microalgae responsible for approximately 40% of marine primary productivity. This algal class has traditionally been regarded as providing the bulk of the food that sustains the marine food chain to top consumers and important fisheries. However, this …
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Size adjustable separation of biologically active molecules
Separation of biologically active molecules (BAM's) is a problem for the pharmaceutical and biotechnology industries. Current technologies addressing this problem require too many techniques, toxic additives, and time to filter desired materials. As a result, a new technology is needed. The …
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Synthetic Studies Of Biologically Active Molecules: Irl 2500, Bruceantin, And Biliatresone
Part 1: Carbon monoxide (CO) is a poisonous gas that binds to hemoglobin, preventing oxygen transport to the tissues. CO poisoning causes ~50,000 emergency room visits per year. Treatments for CO poisoning are extremely limited. IRL 2500 is a small molecule allosteric effector of hemoglobin that …
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CHARACTERIZATION OF BIOLOGICALLY ACTIVE MOLECULES OFPHARMACOLOGICAL INTEREST EXTRACTED FROM MICROALGAE BYBIOSUSTAINABLE PROCESSES
… for the sustainable extraction of microalgal bioactive molecules, prioritizing the use of green solvents such as dimethyl carbonate (DMC), in line with the principles of green chemistry. The study focused on the cultivation of the Micractinium pusillum (CELP1) strain, isolated from agricultural …
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Exploring Enantioselective and Multicomponent One-Pot Reactions Utilizing Alkynes as Linchpins Toward Biologically Active Molecules
… synthetic methodology to make complex small molecules that are of biological importance is a highly investigated area. Utilizing fundamental bond-making reactions, like the Diels-Alder reaction and the Nazarov cyclization, in new efficient one-pot methodologies can help to expand the scope of …
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Allylic C—H activation to access anti-1,3-amino alcohol motifs
… alcohols are common motifs in a variety of biologically active molecules including antivirals, antibiotics, antifungals, and various alkaloids. Due to their prevalence and utility as synthetic intermediates, a variety of methods have been developed to access these motifs in a …
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A comparison of thermodynamic models for the prediction of phase behavior in aqueous-polymer two-phase systems
… been applied to separations involving biological molecules for at least a quarter of a century. In particular, these systems are inexpensive, efficient, and provide a mild (aqueous) and possibly stabilizing environment for fragile biologically-active molecules. These systems may also be designed …
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Sub threshold high frequency electrical field stimulation effect for angiogenesis and vegf expression in cardiomyocytes and heart tissue. Remodelling in the heart: impact of mechanical stretch, threshold and sub-threshold electrical stimulation on cultivated cardiomyocytes and sympathetic neurons /
… of electric field and stretching effect on biologically active proteins. In this work the following research tasks are answered: To investigate the effect of sub threshold electrical stimulation on vascular endothelial growth factor regulation in cultured neonatal rat ventricular myocytes. …
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Vibrational characterisation of coordination and biologically active compounds by means of IR absorption, Raman and surface-enhanced Raman spectroscopy in combination with theoretical simulations
… contains vibrational investigations of some biologically active molecules performed by means of Raman spectroscopy together with theoretical simulations. The SER spectra of these molecules at different pH values have also been analysed and the adsorption behaviour on the metal surface as well …
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Underutilized Dineophiles: Asymmetric Diels-Alder Reaction of Ynones and Ynoates with Oxygen-Functionalized Dienes
… are useful intermediates for the synthesis of biologically active small molecules. Biologically active molecules are not the only targets of the Diels-Alder reaction, other cases have used the cycloaddition to develop novel ligands, and create polymers. My research focus is on the use of …
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Enzym-katalysierte kinetische Racematspaltung von Tramadol-Analoga und deren industrielle Anwendbarkeit
… is member of a large group of biologically active chiral compounds which contains, besides an aromatic hydroxy no other functional groups suitable for a hydrolase catalyzed reaction. The second group of investigated substrates has an additionally secondary hydroxy group in the …
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Coordination Chemistry in Biology and Medicine
… visualize various diseases by linking the radioactive metal cation to biologically active molecules. One type of bifunctional chelator is the single amino acid chelates (SAACs), which can be effectively coordinated to the {Re(CO)3}+ core through the chelating terminus. The other terminus can be …
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AB INITIO and DFT computational study of Myristinin A and A structurally- related molecule
The computational study of biologically active molecules is particularly important for drug development because it provides crucial information about the properties of a molecule, which determine its biological activities. The current work considers the results of a computational study of …
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A metabolomics approach for targeted isolation and production of bioactive secondary metabolites in microbial isolates from extreme environments
… which are responsible for a variety of biologically active molecules with a wide range of pharmaceutical properties. There is a lack of novel effective drugs for metabolic diseases, cancer and parasite infections as well as TNF-alpha inhibitors hence; underexplored marine bacteria could …
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Development of Novel Methods for the Installation of Trifluoromethyl/Boryl and 1,2,4-Oxadiazole Moieties
… the trifluoromethyl group (CF3) into organic molecules since it significantly affects reactivity, as well as the biological and pharmaceutical properties of the molecule. The α-trifluoromethylacrylates are useful synthetic intermediates for the synthesis of trifluoromethyl-bearing nucleosides …
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Stress relief: Exercising Lewis acid catalysis for donor-acceptor cyclopropane ring-opening annulations, a basis for new reaction methodologies
… or small, are assembled to serve as signaling molecules, protective agents, and fundamental composites of higher-order frameworks for the operation and survival of life. Over the years, chemists have isolated and synthesized these molecules, known as natural products, to understand and evaluate …
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Asymmetric Synthesis of Nitrogen Containing Bioactive Compounds via the Utilization of Enantiopure p-Toluenesulfinimines
… the asymmetric synthesis of nitrogen-containing biologically active molecules, such as pyrrolidines, piperidines and other alkaloids. To further illustrate the utility of sulfinimine -derived enantiopure N-sulfinyl anti- α-lkyl β-amino ketones, they was applied to the asymmetric synthesis of the …
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Estrazione di composti biologicamente attivi da piante della Sardegna
… A further aim of this work was to separate biologically active molecules and nutraceuticals by means of SFE at high pressure. The investigated species have been selected on the basis of ethnobotanic information regarding, in particular, species endemic of Sardinia or that can be easily …
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Oxidative Heck Reactions with Terminal Olefins
… three-component coupling reaction provide an attractive manifold for the rapid build-up of dense functionality around terminal olefins with minimal protecting group strategies or undesirable oxidation/reduction reactions.The synthetic utility of this reaction has been demonstrated through the …
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CONVENIENT ETHERIFICATION USING TRICHLOROACETIMIDATES AND SYNTHESIS OF AMINOSTEROID SHIP INHIBITORS
… in organic chemistry, and are often present in biologically active molecules. The protection of hydroxy groups is crucial in long multi-step synthetic routes, as the unprotected alcohol is typically not compatible with many reagents. Alcohols are often protected as corresponding benzyl ether, …
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