Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"biological weapon"”.
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Biological Weapons and Terrorism
… examples of terrorists desiring or achieving a biological weapons capability. The second part of the thesis aims to understand the effects of the biotechnology revolution on biological weapons programs. The final chapter uses this analysis to assess terrorists' interest in a biological weapon …
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Rationalising the effect of guanine-based Ricin inhibitors using computer simulations
for humans.This has lead to its use as a biological weapon and a therapeutic agent. the reaction mechanism of ricin is not known and so rational design is limited, resulting in no effective inhibitor being found for this enzyme. An important step towards understanding the reaction mechanism and the …
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In silico investigation of the mechanism of ricin-catalysed depurination reaction and design of novel ricin inhibitors
… 0.1-1.0 ug/kg. This has lead to its use as a biological weapon. Cell death is caused when ricin ceases the protein synthesis by removing a specific adenine (A-4324) of the GAGA tetra loop of 28S ribosomal RNA. Despite this destructive feature, ricin has been touted as a potential therapeutic …
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Quantitative assessment of methods for bacterial and viral purification and concentration
… pathogen detection, SARS-CoV-2 detection, to biological weapon detection, the samples we analyze include much more than our target organism. To accurately detect our targets of choice, the use of various labor intensive, and at times costly techniques, have been used to purify and concentrate …
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New virulence mechanisms in Yersinia pestis, the plague (Black Death)-causing bacterium: A re-emerging and bioterror pathogen
… A select agent based on its potential use as a biological weapon. Currently, there is no vaccine licensed in the United States for use against Y. pestis so continued research on understanding the pathogenesis of Y. pestis and identifying new virulence factors is warranted. Although the natural …
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THE BIPC MINOR TRANSLOCASE MEMBRANE PROTEIN OF THE BURKHOLDERIA TRANSLOCON
… the Burkholderia family has been utilized as a biological weapon during World War I. Burkholderia pseudomallei is the causative agent of melioidosis, a disease that impacts humans along with some animals. Melioidosis causes severe infections that have diverse manifestations. Melioidosis …
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The Roles of the Germination-Specific Lytic Enzymes CwlJ1, CwlJ2, and SleB in Bacillus anthracis Spores
… discourage the use of B. anthracis spores as a biological weapon.
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Regulation of the Spore Cortex Lytic Enzyme SleB in Bacillus anthracis
… a threat due to its potential to be used as a biological weapon. The spore form of this bacterium is an extremely resistant structure, making spore decontamination exceptionally challenging. During spore germination, nutrient germinants interact with Ger receptors, triggering a cascade of …
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Neurological Consequences of Viral Encephalitis: Behavioral Deficits, Neuronal Restructuring, and Therapeutic Interventions
… implications, including its potential as a biological weapon, VEEV remains understudied, particularly regarding its chronic effects on memory and neuronal function. Therefore, this work bridges the gap to identify critical features of neuron loss and neuron restructuring that lead to …
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Identification of protective rickettsial antigens for vaccine development
… a select agent that could be used as a biological weapon. Although Rickettsia spp. cause important diseases of public health importance and there is a need to develop countermeasures for biodefense, there are no commercially available vaccines. Resistance to rickettsial infections and …
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Site-Directed Mutagenesis in Francisella Tularensis by Allelic
… tularensis has long been considered a potential biological weapon and is now classified as a category A select agent by the National Institutes of Health and the Centers for Disease Control and Prevention. The investigation of the mechanisms of pathogenesis by F. tularensis type A and B strains …
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Evaluation Of Immunogenicity Of Transgenic Chloroplast Derived Protect
… Control (CDC) lists anthrax as Category A biological agent due to its severity of impact on human health, high mortality rate, acuteness of the disease and potential for delivery as a biological weapon. The currently available human vaccine in the United States (AVA anthrax vaccine …
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Host response of lung cells to virulent Bacillus anthracis
Bacillus anthracis, the etiological agent of anthrax, is a Gram-positive, spore-forming bacterium that is classified as a Category A select agent. The current paradigm in anthrax literature labels the alveolar macrophage (MØ) as the primary cell utilized by spores as a safe site for germination and …
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The Origin of Multiple Sclerosis Revisited: The Case for a Soluble Toxin
… targets cells may help counteract its use as a biological weapon. Furthermore, this discovery may open new avenues for translational research, e.g. novel methods for targeting and bypassing the blood-brain barrier; a major hurdle to drug delivery in the central nervous system.</p>
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Genetic Control of Survival and Weight Loss during Pneumonic Burkholderia pseudomallei (Bp) Infection
… issue because of its high potential for use as a biological weapon. The US Centers for Disease Control and Prevention (CDC) and The Department of Health and Human Services (DHHS) has recognized Bp as a Tier 1 Select Agent, meaning there is no effective vaccine against this high morbidity/mortality …
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Enabling early stage drug discovery targeting high molecular mass penicillin-binding proteins in <i>Yersinia pestis</i>
… to acquire resistance, its potential as a biological weapon,high mortality caused by plague and its increasing prevalence, all highlight the need for investigating novel therapeutic strategies against this pathogen. It is possible that enzymes from the peptidoglycan biogenesis pathway, …
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The Expression of Chikungunya Virus Envelope 2 Glycoprotein Variants in Nicotiana benthamiana for the Development of a Diagnostic Reagent
… by the United States army as a potential biological weapon used for bioterrorism owing to the potential for infection via aerosol. CHIKV is primarily transmitted by infected Aedes aegypti mosquitos and is currently distributed in Africa, parts of Asia and South, Central and North America. …