Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 81 for “"biological response"”.
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Characterising the biological response to ultraviolet radiation
… cream. Therefore it is desirable to have a more biologically relevant method to assess UVA protection offered by a sun cream. The work in this thesis focuses on the identification of a robust biomarker of UVA exposure, with the aim to identify biomarkers of UVA that could be used to assess the …
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Nitrogen dynamics and biological response to dairy manure application
… and carbon cycling, crop yield, and biologic responses to proxy soil health. In a forced air-flow laboratory incubation, manure injection reduced ammonia volatilization by 87% and 98% in a sandy loam and clay loam soil, respectively. The increased ammoniacal nitrogen recovery resulted in …
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Biological response to 8-oxoguanine base released during DNA base excision repair
… and carcinogenesis; however, the cellular response to free 8-oxo-Gua has never been investigated. Initial experiments show that 8-oxo-Gua induced premature senescence in a concentration-dependent manner when added to the medium of human diploid fibroblasts (HDFs), while other oxidized and …
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The Effects of Biological Response Modification and Diet on the Immune Respose of Tumor-bearing mice
… post-injection had substantially increased CIL response while those from Diet 8 mice were only slightly enhanced. Interferon, interleukin-2 and prostaglandin E<sub>1</sub> most effective. NK activity remained essentially unchanged regardless were of diet group or modifying treatment.</p>
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Device design factors for enhancing the functionality of chronic intracortical microelectrodes
… is hampered by a series of inflammatory tissue responses. The consequence of the inflammatory response is the formation of a dense astroglial sheath around the vicinity of the electrode, impeding the electrical conduction between the electrode and neurons. Furthermore, due to the cascade of …
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Monthly variability in upper ocean biogeochemistry due to mesoscale eddy activity in the Saragasso Sea
… age of the eddy, which was very important to the biological response. In general, eddies that were one to two months old elicited a large biological response; eddies that were three months old may show a biological response and were accompanied by high thorium flux measurements; eddies that were …
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Monthly variability in upper ocean biogeochemistry due to mesoscale eddy activity in the Saragasso Sea
… age of the eddy, which was very important to the biological response. In general, eddies that were one to two months old elicited a large biological response; eddies that were three months old may show a biological response and were accompanied by high thorium flux measurements; eddies that were …
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Irradiators for measuring the biological effects of low dose-rate ionizing radiation fields
Biological response to ionizing radiation differs with radiation field. Particle type, energy spectrum, and dose-rate all affect biological response per unit dose. This thesis describes methods of spectral analysis, dosimetry, biological assays, and mathematical modeling for determining the …
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Expanding the Spiroligomers Toolbox as Protein-Protein Interaction Inhibitors
… cells through passive diffusion and induces a biological response in both a dose- and time-dependent manner. The synthesis of additional spiroligomer analogues achieved low micromolar to high nanomolar range activity during screening in direct and competitive binding assays. In parallel to the …
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Targeted drug delivery within the eye
… growth factor protein therapeutic gave a better biological response of suppressing neovascularization with 11,900 times less dosage compared to topical administration. The second part of the research aims to develop novel formulations to target ciliary body and choroid via suprachoroidal …
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Recapitulating Dynamic Disease States from In Vitro to In Vivo: The Pathophysiology of Cell Fusion in Breast Cancer Metastasis and New Model Systems of Intracranial Aneurysm
… flow patterns within IAs and the resulting biological response. While there are multiple methods of treatment, all come with high risk to the patient and are designed to mechanically occlude blood flow while ignoring the underlying biological mechanisms at play. Current model systems both in …
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Interactions Between Polyethylene Glycol Chains and Proteins and Chemically Selective Surfaces
… PEG is not an inert, simple polymer whose biological activity, especially, vis-a-vis proteins, can be solely described via descriptions of 'simple' polymers such as the excluded volume or scaling theory. Rather, these studies show that its biological response is coupled to the specific …
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The WNT signalling pathway in Ewing sarcoma/primitive neuroectodermal tumour : an immunohistochemical investigation
… study on ES cell lines using RT-PCR analysis and biological response assays suggests that an intact WNT pathway exists in ES and that addition of exogenous WNT ligands enhances cell motility. Based on this we hypothesize that the WNT pathway may play a role in the biology of ES/PNET and we aim to …
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Effects of Surface Characteristics of Hydroxyapatite and Substituted Hydroxyapatites on Protein Attachment and Angiogenesis
… has been applied widely in dentistry. While the biological performance of these materials has been of interest for many years, it remains unclear how distinct material characteristics influence the bioactivity due to the intertwined nature of physical and electrochemical surface properties. The …
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High-Throughput Mapping of The Biological Effects of Particle Therapy
… linear energy transfer (LET) specific relative biological effectiveness (RBE) when compared to photons. It is essential to employ accurate biophysical models for particle beams in order to maximize the therapeutic potential of particle therapy through the introduction of biologically optimized …
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Scaffold-Mediated Organization of Signal Transduction Networks
… transformation and apoptosis, and is engaged in response to growth factors, cytokines, morphogens, and other extracellular stimuli. Given the ubiquitous nature of this signaling pathway, it is not clear how specialization with respect to various Raf-dependent phenomena is acquired. In theory, …
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Current Strategies and New Avenues in the Management of Non-Infectious Ocular Inflammation
… therapy, consequently they are offered biological response modifiers. They are fundamentally more effective, but it is not typically recommended at first, given its high cost and lack of long term pharmacokinetics data. Nevertheless, the remission rate has not change significantly, …
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Chondrocyte metabolism and matrix nano-electromechanics : the response to cartilage tissue shear deformation
… by which mechanical signals are converted to a biological response are not completely understood. Therefore, the knowledge of both biological and biophysical aspects of cartilage is important to understand the dynamic interaction between the cells and matrix. In this study, the electromechanical …
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Coaxial Electrospinning of Synthetic/Natural Polymer Combinations for Controlled Release of Active Components in Biomedical Applications
… incorporating extracellular matrix proteins and biologically active components. By systematically investigating process parameters, this study elucidates the structural and functional properties of coaxial fibres and their implications for biological response. Extensive characterisation …
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