Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 93 for “"biological relevance"”.
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Assessment of anthropocentric representations of color patterns for biological relevance
Studying animal coloration is a notoriously difficult task as animals differ in their visual system properties (number of cone cells, spectral sensitivities of cone cells, filtering properties of ocular media, etc.) and thus may perceive and respond to stimuli differently than we do. These …
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DISSECTING THE CLINICAL AND BIOLOGICAL RELEVANCE OF DIS3 GENE IN MULTIPLE MYELOMA
… approaches. These studies have been of high relevance to better understand the biology of the disease, to identify of novel prognostic and predictive biomarkers and putative therapeutic targets. DIS3 (chr.13q22.1 localization) is a conserved exoribonuclease and catalytic subunit of the …
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Regulation of INTS-6 by post-translational modifications: exploring phosphorylation, SUMOylation and their biological relevance in Caenorhabditis elegans
… Finally, this work aims to highlight the relevance of both basic research, which is essential for unraveling processes at the molecular level, and computational tools, which offer complementary approaches when classical techniques prove challenging. Together, these efforts contribute to …
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Criticality control of insulin release: a novel alternative for detailed modelling of insulin secretion
… resulting model. These were chosen due to their biological relevance and capability of generating a wide range of dynamics using a relatively simple formulation. The resulting model is comprised of a set of sixteen coupled oscillators organized into four clusters. It successfully incorporates …
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Lipopolysaccharide in marine bathing water; a potential real-time biomarker of bacterial contamination and relevance to human health
… with the Kinetic QCL™ LAL assay. The potential biological relevance of Bacteroides LPS was also investigated in cell culture models indicating that Bacteroides showed similar induction of proinflammatory cytokines (TNF-α, IL-6 and IL-1α) and generally the biological activity was approximately …
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INFORMATION BASED ADAPTIVE PATH PLANNING AND SAMPLING FOR ENVIRONMENT MONITORING
… or a team of robots. Moreover, we examine the biological relevance of the field estimated using such frameworks. This work also presents a solution to the problem of simultaneous sampling and monitoring of an environmental field. Finally, this work explains a data-driven framework for system …
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Solution structure and biochemistry of an intramembrane aspartyl protease (IAP)
… of cancers. Despite their broad medical and biological relevance, structural and mechanistic details of IPs have remained largely obscure. A continuous FRET peptide assay, which is fast, robust, and high throughput, and can be applied to screen multiple conditions simultaneously, is …
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Characterization of Gene-by-Age Interaction and Gene-by-Gene Interaction In Coronary Artery Disease
… been limited by missing heritability and lack of biological relevance of identified variants. We sought to address these issues by characterizing interaction among genotypes and environment using case-control samples enrolled at Duke University Medical Center. First, we studied the impact of age …
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Distributional Fingerprinting of Cell Population Phenotypes and Drug Activities
<p>From gene expression to protein abundance, biological measurements have traditionally been taken as population averages. Studies over the past decade, however, have established the biological relevance of population heterogeneity, even for cells with identical genetic background. The …
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Functional and developmental characterisation of matrix binding sites in decapentaplegic
… pleiotropic effects, not possible to examine the relevance of matrix interactions for single pathways. The aim of this work was to examine the relevance of matrix interactions for the TGF-ß superfamily member DPP. Based on the fact that DPP is highly homologous to human BMP-2, the basic N-terminus …
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Isoform-Specific Variant and Expression Analysis of Epigenetic Genes in Neurodevelopment and Disease
… gene in particular showed both statistical and biological relevance, making it a strong candidate for future study. Conclusion This study supports the importance of transcript-aware variant interpretation and highlights the potential for discovering novel disease mechanisms through …
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Electronic spectroscopy of flavins in a cryogenic 22 - pole ion trap
Flavins are of great biological relevance, but little information is known about the isolated flavins. This dissertation deals with the electronic photodissociation spectroscopy of cryogenically cooled flavins. The optical spectra are recorded with a tandem mass spectrometer coupled to a cryogenic …
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Investigating Parkinson’s Disease human iPSC-derived models through single-cell gene expression
… to assess their cellular heterogeneity, in vivo biological relevance, and investigate novel use cases for PD research. The aim of this thesis is to understand how these factors influence current use cases of iPSC-based models in neuroscience research and to improve the existing model. Methods: We …
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Two-dimensional Spectroscopy of Molecular Excitons in a Model Dimer System
… vibrational coherences are of questionable biological relevance at face value, we conclude with a discussion on initial findings using coherently controlled 2D spectroscopy, where we observe long-lived signatures associated to vibronic coherences at room temperature. These results point to …
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Exploring the camouflaged and non-coding genome: analysing difficult genomic regions in human disease genetics
… is human-specific, further emphasizing the biological relevance of camouflaged and non-coding regions in the context of human evolution. Throughout this thesis, a human-specific perspective was adopted, recognizing the unique genomic features that shape our species. By expanding our …
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Functional Characterization of the C-terminal Cholinesterase-Like (ChEL) Domain of the Thyroid Hormone Precursor Protein
… generation. However, the <em>in vivo</em> biological relevance of the Tg-ChEL domain (in the absence of the remaining Tg molecule) is entirely unknown. Furthermore, the functional effects of several Tg-ChEL mutations responsible for congenital hypothyroidism remain to be elucidated. This …
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Understanding the assembly of simple ssRNA virus nucleocapsids
… in vivo, enabling the experimental scale and biological relevance to increase substantially. VEE pre-viral nucleocapsid cryo-EM reconstructions were successfully achieved, but at low resolution. Given, again, the heterogeneity of the system at this maturation stage, it is more an insight into …
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A New Approach to Drug Delivery: Non- Peptidic, High Load Macrocyclic Alternatives to Cell Penetrating Peptides
… for various applications including those of biological relevance. The copper catalysed alkyne-azide cycloaddition (CuAAC) reaction is also introduced as a tool for functionalising calixarenes. The phenomenon of cell penetration is of interest where a molecule has an intracellular target, for …
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The elastic behavior of polymer chains: theory and simulations
… behavior of polymer molecules with biological relevance. In particular, this essay deals with the thermo-elasticity of single polymer molecules subjected to uniform stretching (generated by an applied force) or non-uniform stretching (generated by an external field). Analytical …
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The specificity and evolution of gene regulatory elements
… of natural selection to detect the conserved biological relevance of miRNAs and their targets. Using this method, I quantify the abundance of different conserved miRNA target types, including different seed matches and 30-compensatory targets. I show that over 60% of mammalian mRNAs are …
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