Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 136 for “"biological phenomena"”.
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Study of biological phenomena implicated in neuromuscular ageing
The neuromuscular junction (NMJ) defines the functional interface between nerve and muscle. Reactive oxygen species (ROS) are linked to pathological denervation in multiple neurodegenerative diseases, but whether and how ROS causes denervation is unclear. Our main hypothesis was that ROS …
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Biomimetic Membranes as New Materials for Applications in Environmental Engineering and Biology
… can enrich our understanding of underlying biological phenomena."
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Geometric Deep Learning for Biomolecules
… a promising pathway to deeper insights into biological phenomena. This manuscript explores the integration of geometric deep learning techniques to model biological structures. By embedding inductive biases based on geometry and physical laws, we aim to enhance our understanding and …
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Mathematical Models, Algorithms, and Statistics of Sequence Alignment
<p>The problem of biological sequence comparison arises naturally in an attempt to explain many biological phenomena. Due to the combinatorial structure and pattern preserving properties of the sequences it attracted not only biologists, but also mathematicians, statisticians and computer …
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Computational approaches for the design and prediction of protein-protein interactions
… is crucial for understanding the underlying biological phenomena, yet explicit atomic-level modeling is computationally prohibitive. Computational protein design, homology modeling, protein interaction prediction, docking and structure recognition are among these applications. Models that are …
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An organoid platform to study alveolar stem cells in lung generation and cancer
… way we model cancer and a vast number of other biological phenomena.
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Development of Integrated Machine Learning and Data Science Approaches for the Prediction of Cancer Mutation and Autonomous Drug Discovery of Anti-Cancer Therapeutic Agents
… able to model increasingly complex chemical and biological phenomena. In this dissertation, we capitalize on these achievements and use machine learning to study drug receptor sites and design drugs to target these sites. First, we analyze the significance of various single nucleotide variations …
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Post-transcriptional control of gene expression
… gene expression control by analyzing data from biological experiments. Most of the work following uses a common mathematical model framework based on Markov chain models to test hypotheses, predict system dynamics or elucidate network topology. Our work lies in the intersection between …
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Microfluidic Assessment of Stem Cell-Derived Pancreatic Beta Cells
… concentration gradients for the study of biological phenomena such as cell migration. Utilization of these devices for cellular fluorescence imaging is also possible, paving the way for more sophisticated methods of dynamic assessment. Herein, we fabricated a pre-designed microfluidic …
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Non-Classical Symmetry Solutions to the Fitzhugh Nagumo Equation.
… are often used to model the behavior of biological phenomena. The Fitzhugh Nagumo partial differential equation is a reaction diffusion equation that arises both in population genetics and in modeling the transmission of action potentials in the nervous system. In this paper we are …
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Using network inference to discover molecular pathways underlying cytokine synergism and age-related neurodegeneration
… to initial parameterization and generating biological hypotheses from the resulting subnetworks can often be difficult. This study increases the interpretability of subnetwork solutions generated PCSF by studying the effect of varying PCSF free parameters and adding annotations for …
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Principled computational methods for the validation discovery of genetic regulatory networks
… enough to capture essential features of biological phenomena and at the same time approachable in terms of their application. We demonstrate how graphical models, and Bayesian networks in particular, can be used to model genetic regulatory networks. These methods are well-suited to this …
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DEVELOPMENTS TOWARDS SINGLE MOLECULE AND SINGLE CELL GENETIC AND EPIGENETIC ANALYSIS TECHNOLOGIES
… in microfabrication and microscopy have opened biological phenomena to be studied in fundamental units rather than as a collective entity. From these efforts, the axioms upon which we built our fundamental concepts in anatomy and physiology have been reshaped. We now understand that even within …
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Microfluidic platforms for studying cell behavior
… platforms have the potential to study these biological processes due to the inherent control over the microenvironment. Here, we used PDMS-based microfluidic platforms to study neutrophil chemotaxis and intercellular signaling. The microfluidic platforms were used to generate stable opposing …
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Advancing Biosecurity in the Age of AI: Integrating Novel Detection, Suppression, and Evaluation Approaches
… a growing challenge: advancing transformative biological science while safeguarding against catastrophic misuse, a tension amplified by the rapid convergence between biology and artificial intelligence. The COVID-19 pandemic starkly revealed our vulnerabilities to self-replicating, exponential …
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Hyperadaptation - Another Missing Term in the Science of Form
… allow evolutionists to more adequately explain biological phenomena.
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Characterising Mechanistic Reasoning of Senior Biology Students in Hong Kong
… Kong were interviewed to give explanations about biological phenomena related to these topics: enzymes and metabolism as well as the breathing system and transport system in humans. Their responses were coded (activity, condition, entity, organisation, and property) based on a framework of …
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Lessons from a rare disease
… aging. Progeria may reveal insights into basic biological phenomena such as gene expression, DNA regulation, RNA splicing, protein processing, cellular aging, and stem cell differentiation. Instrumental to the discovery of the progeria gene and the growth of scientific interest since 2002 has …
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Profiling, prototyping, and perturbing human immune responses
… practice has been rare. Recent advances in biological methods and instrumentation allow the analysis and manipulation of limited quantities of human samples, shifting focus away from inbred mice and allowing an alternative research framework to emerge. This approach aims to …
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