Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"biological optimization"”.
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Computational Targeted Codon Optimization and Translation with Deep Learning
Codon optimization—the task of recoding a protein’s underlying DNA sequence to maximize expression in a target organism—is a complicated biological optimization problem. Each gene brings a dynamic combination of local and long-range dependencies along with globally imposed constraints specific to …
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Adaptive Intensity Modulated Radiation Therapy Planning Optimization with Changing Tumor Geometry and Biology Enforcing Both Cumulative and Fraction Size Dose Constraints
… This research presents promising iterative optimization approaches that re-optimize and update the treatment plans periodically by incorporating the latest tumor geometry information. Two realistic lung cases simulating practice, based on anonymized archive datasets, are used to test the …
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Radiation biophysical modeling of the FLASH effect: from mechanistic understanding towards clinical endpoint prediction
… of experiments supporting the FLASH effect, the biological mechanism underpinning it is still unclear and highly debated after 10 years from its discovery. Different possible explanations have been proposed, such as (i) transient hypoxia due to O2 depletion, (ii) organic radical recombination, …
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Modeling Proton Relative Biological Effectiveness Using Monte Carlo Simulations of Microdosimetry
… is also known to offer an enhanced relative biological effectiveness (RBE) compared to photons. In the current clinical standard, RBE is fixed at 1.1 at all points along the proton beam, meaning protons are assumed to require 10% less dose than photons to achieve target coverage and organ at …