Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 49 for “"biological matrices"”.
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Hyphenated techniques for speciation of Se in biological matrices
The nutraceutical market has become overwhelmed by the presence of Se-preparates. The lack of control and legislation is problematic. As Se is both essential and toxic, information on the total concentration and species are of the utmost importance. Therefore in this work methods were developed …
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Optimal Analysis of Sulfonamides From Biological Matrices Using Supercritical Fluids
… efficiency of the polar sulfonamides from the biological matrices and also reduced the amount of co-extractives. The next phase of this research considered the effect of organic modifier and CO2 in the SFE of sulfonamides from chicken liver, beef liver and egg yolk. Methanol, ethanol, acetone, …
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A Capillary-Based Microfluidic System for Immunoaffinity Separations in Biological Matrices
The analysis of biological samples in clinical or research settings often requires measurement of analytes from complex and limited matrices. Immunoaffinity separations in miniaturized formats offer selective isolation of target analytes with minimal reagent consumption and reduced analysis times. …
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High-throughput analysis of emerging and historical pollutants in biological matrices.
… with our ability to analyze contaminants in biological tissue in a timely manner. These deficiencies in laboratory capacity and preparedness demonstrated a critical need to develop and validate high-throughput analytical methods capable of rapid and accurate quantification of organic …
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ESTABLISHING DRIED MATRIX SPOT PROTEOMICS FOR DISCOVERY IN VARIOUS BIOLOGICAL MATRICES
Η πρωτεομική αποτελεί έναν από τους σημαντικότερους και ταχύτερα αναπτυσσόμενους τομείς της σύγχρονης βιοϊατρικής έρευνας, καθώς επιτρέπει τη συστηματική μελέτη του συνόλου των πρωτεϊνών που εκφράζονται σε ένα κύτταρο, έναν ιστό ή έναν οργανισμό σε δεδομένες συνθήκες. Οι πρωτεΐνες αποτελούν τα …
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Practical application of machine learning for analyses of biological matrices and environmental phenomena.
… learning methods as a method of studying complex matrices and environmental phenomena. A number of machine learning methods in the form of linear projection algorithms and statistical experimental designs were applied for qualitative analysis of different matrices. The used linear projection …
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Mass spectrometry-based identification and quantitation of endogenous peptides in complex biological matrices
… The detection of the peptide complement in a biological sample is an analytical challenge due to the broad range of concentrations and diverse chemical properties of endogenous peptides. The presence of other classes of molecules, like salts and lipids, add to sample complexity and further …
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High performance liquid chromatography-tandem mass spectrometry of pharmaceuticals and personal care products in environmental and biological matrices
… in recent years as a new class of chemical and biological pollutants in our environment. In the search for suitably sensitive and specific techniques for detection of these compounds at very low concentrations, liquid chromatography-tandem mass spectrometry (LCMS/ MS) has emerged as the new …
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FORENSIC TOXICOLOGY IN UNCONVENTIONAL BIOLOGICAL MATRICES: THEEMERGING ARCHAEOTOXICOLOGICAL FIELD APPLIED TO BONE REMAINS ANDBRAIN TISSUE IN ANCIENT POPULATIONS
La tossicologia forense è una branca specializzata della tossicologia che svolge un ruolo cruciale nelle scienze forensi, rilevando e interpretando la presenza di sostanze esogene all'interno di matrici biologiche a fini medico-legali. La tossicologia forense include analisi sia qualitative che …
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Development of novel extraction and separation methods for the determination of anthracyclines and taxanes simultaneously from biological matrices
For certain types of advanced cancers patients may be given a combination of an anthracycline and a taxane for chemotherapy treatment. Despite the fact that a mixture of anthracyclines and taxanes may be administered simultaneously to patients and that accurate measurement of drug levels during …
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Quantitation of enteroendocrine hormones as metabolic disease biomarkers in human biological matrices by liquid chromatography tandem mass spectrometry
… used to isolate small molecule analytes from biological matrices. Assay development can be a challenging process, especially when the target biomarker is expected to be in the low (picomolar) ranges. To improve sensitivity of the methods a number of different extraction procedures were …
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Forensic Analysis of Trace Evidence Fibers and Drugs of Abuse In Biological Matrices Using Chromatographic and Mass Spectrometric Methods
… techniques for the analysis of drugs of abuse in biological </p> <p> matrices using disposable pipette extraction (DPX) are described. DPX uses a loosely extraction sorbent contained inside of a pipette tip allowing dynamic mixing with the sample and selective elution of analytes. Whole blood …
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The detection of drugs of abuse in biological matrices using enzyme-linked immunosorbent assay and liquid chromatography-tandem mass spectrometry
… for the detection of drugs of abuse in biological matrices. Overall the LC-MS-MS method showed good correlation results for opiates compared to the GC-MS method. 6-MAM was however detected in more root segments and segments excluding roots by LC-MS-MS. Morphine was detected in a greater …
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Avaliação de métodos de preparação de amostras utilizados em bioensaios
The analysis of a biological material is of great interest to a number of areas, including the pharmaceutical field. In these analyzes are made the detection and / or quantification of substances of interest , which are the analytes and biomarkers. The biological matrices are highly complex and …
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Direct drug screening and lipid profiling using ambient mass spectrometry
… stands in an outstanding position in analysis of biological specimens owing to its abundant structural information, high accuracy, incomparable sensitivity, high speed, and the large variety of its applications. The ion source, an instrumental part for converting the analyte into ions, has played …
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The Role of Megalin in Aminoglycoside-Associated Toxicity in the Kidney
… to measure amikacin concentrations in different biological matrices, cellular uptake studies were used to gather insights of the potential role of megalin in amikacin uptake, and animal studies were used to evaluate potential pharmacotherapeutic interventions that may reduce the occurrence of …
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On-trap derivatization of short-chain fatty acids
… capable of trace analysis of SCFAs in complex biological matrices. Previous studies by others using multibed-sorbent traps, solid phase microextraction (SPME), and on-fiber derivatization with SPME showed that it is possible to achieve low limits of detection (LODs) for the gas chromatographic …
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APPLICATION OF OMICS APPROACHES IN DRUG DISCOVERY AND BIOMARKER IDENTIFICATION
… have represented a revolution in many fields of biological research. Among these, lipidomics and metabolomics are gaining increasing interest due to their close connection with the organism’s phenotype. As the main analytical goal of omics approaches is to identify and quantify as many compounds …
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Expanding the Capabilities of Paper Spray Mass Spectrometry: High-Throughput Drug Screening and On-Paper Electrokinetic Stacking
… high sensitivity in analysis of complex biological matrices. This dissertation explores approaches to enhance the capabilities and applications of PS-MS, with a particular focus on overcoming sensitivity limitations. Chapter 2 demonstrates the potential of PS-MS in forensic toxicology …
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