Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"biological macromolecules"”.
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The ultrafiltration of biological macromolecules.
Thesis. 1976. Ph.D.--Massachusetts Institute of Technology. Dept. of Chemical Engineering.
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Top-Down Interrogation And Characterization Of Biological Macromolecules
<p>Analytical mass spectrometry has been widely applied in the field of biomolecule identification and characterization. It provides fast, accurate and robust information relevant to the molecular mass, composition and structure of the target analytes.</p> <p>This thesis is focused on the top-down …
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Dynamics of biological macromolecules investigated by fluorescence depolarization
"The fast dynamics of biomolecular systems are believed to be important to their physiological function. Fluorescence depolarization is a powerful technique for the investigation of these dynamics. A general overview of the use of time-resolved fluorescence to investigate nanosecond dynamics is …
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Dynamics of biological macromolecules investigated by fluorescence depolarization
"The fast dynamics of biomolecular systems are believed to be important to their physiological function. Fluorescence depolarization is a powerful technique for the investigation of these dynamics. A general overview of the use of time-resolved fluorescence to investigate nanosecond dynamics is …
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Investigation of biological macromolecules using atomic force microscope-based techniques
… instrument for investigating and manipulating biological samples down to the subnanometer scale. In contrast to other microscopy methods, AFM does not require labeling, staining, nor fixation of samples and allows the specimen to be fully hydrated in buffer solution during the experiments. …
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Microscopic description of gas permeation and delivery pathways in biological macromolecules
Life on Earth fundamentally and indispensably relies on proper regulation and metabolism of inorganic molecules such as dioxygen (O2), nitric oxide (NO), carbon dioxide (CO2) and ammonia (NH3). These chemical species often act as substrates of enzymes and/or as ligands modulating biochemical …
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Gas-Phase Covalent And Non-Covalent Ion/ion Chemistry Of Biological Macromolecules
… new area for identifying and characterizing biological analytes.</p>
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MOLECULAR DYNAMICS SIMULATIONS OF BIOLOGICAL MACROMOLECULES: APPLICATIONS TO STRUCTURAL VACCINOLOGY AND PEPTIDE DESIGN
This thesis work is splitted into two parts. The first one is about a computational method for epitope predictions on antigenic proteins, while the second one is related to the characterization of folding/unfolding processes of small natural polypeptides. Starting with the first topic, an …
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An Infrared Study of the Metal Ion Complexes of Model Systems Related to Biological Macromolecules
Made available in DSpace on 2014-12-09T17:35:23Z (GMT). No. of bitstreams: 1 6604217.pdf: 1977366 bytes, checksum: b48f84b211551793b9d6431a2d41a6a3 (MD5) Previous issue date: 1965
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Synthetic and Computational Studies on Polycyclic Aromatic Hydrocarbon Derivatives, Nucleoside Analogs and Peptides
… understanding of the structure and functions of biological macromolecules has advanced rapidly, the result of which is a better mechanistic understanding of many biological processes. As an outgrowth of this understanding, organic molecules that react with biological macromolecules (DNA) or adopt …
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Molecular Engineering of a Single-Chain FV Antibody Fragment to Femtomolar Affinity
… optimizing recognition parameters of biological macromolecules.
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Molecular specificity of substrate recognition and activation in cytochrome P-450(CAM)
The mechanisms by which biological macromolecules recognize small molecules are of fundamental relevance to the maintenance of living systems and the chemistry of noncovalent bonding. Hydrogen bonding and hydrophobic interactions have been implicated in binding and activation of hydrocarbon …
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Fabrication and control of microfluidic devices for on-chip synthesis
Introduction: In biological research today, there is great demand for synthesized biological compounds. The sequencing of the Human Genome has been completed, as well as that of many other organisms. Current work is now shifting towards the production of biological macromolecules. More …
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Genetic variation of rana fuscigula in Southern Africa
… in describing and explaining diversity in the biological world. The discovery of the molecular basis of inheritance has led to rapid increase in the use of biological macromolecules in these investigations. Scientists now routinely investigate the DNA of a range of organisms. The elationships …
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The synthesis of nanoporous hydrogels using sacrificial block copolymers
… the separation, based on size selectivity, of biological macromolecules such as proteins. Hydrogels with nanoscale structure were synthesized using amphiphilicpoly(c-caprolactone-b-ethylene oxide-b-s-caprolactone) (PCL-b-PEO-b-PCL) triblock copolymers. The triblock copolymer was produced by the …
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Opto-Electronic Modulation of Quantum Dots by Cells and Bioactive Molecules
… on their interactions with other systems. For biological systems, research has focused on the biocompatibility and cytoxicity of QDs in the context of imaging/therapy. However, there is a paucity of work on how biological systems and bioactive molecules might be used to alter the …
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Mathematical Modeling of Microscale Biology in Polyelectrolyte Brushes
<p>Biological macromolecules including nucleic acids, proteins, and glycosaminoglycans are typically anionic and can span domains of up to hundreds of nanometers and even micron length scales. The structures exist in crowded environments that are dominated by multivalent electrostatic interactions …
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An Investigation of Phase Behavior and Crystal Nucleation Kinetics in Solutions of Globular Proteins
… can be found in the crystallization of globular biological macromolecules. Recent progress has been made in locating conditions favorable for crystal growth based on characterizing the strength of particle interactions. The strength of particle interactions can be controlled using solution …
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Innovative Purification Protocol for Heparin Binding Proteins: Relevance in Biopharmaceutical and Biomedical Applications
… showed that the FGF-1 and the D2 are in a native biologically active conformation. The findings of this study will not only aid an in-depth investigation of this class of proteins but will also provide avenues for inexpensive and efficient purification of other important biological …
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