Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"biological databases"”.
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Knowledge discovery in biological databases : a neural network approach
Knowledge discovery, in databases, also known as data mining, is aimed to find significant information from a set of data. The knowledge to be mined from the dataset may refer to patterns, association rules, classification and clustering rules, and so forth. In this dissertation, we present a …
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SEMEDA (Semantic Meta-Database) : ontology based semantic integration of biological databases
… on the one hand the current state of molecular biological databases, their heterogeneity and the integration of molecular biological databases. On the other hand the current usage of ontologies in general and with special regard to database integration is described. The principles of semantic …
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GCell A Sub-Cellular Localization Tool
The aim of this thesis is to develop a biological database mining tool that incorporates mining of various publicly available heterogeneous databases and provides researchers with a reporting and visualization tool for sub-cellular localization of genes and proteins. Although there is little …
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Multimodal Networks in Biology
… construct that captures the structure of biological networks, computational network models, and relationships from biological databases. An MMN subsumes the structure of graphs and hypergraphs, either undirected or directed. Formally, an MMN is a triple (V,E,M) where V is a set of …
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Do RNA-dependent polymerases share common ancestry? A bioinformatic approach
… that generates new knowledge from existing biological databases. For any bioinformatic analysis, it is important that the most accurate method(s) be used. The first portion of this thesis is a comparative evaluation of six programs designed for the local alignment of protein sequences. The …
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New techniques for improving biological data quality through information integration
As databases become more pervasive through the biological sciences, various data quality concerns are emerging. Biological databases tend to develop data quality issues regarding data legacy, data uniformity and data duplication. Due to the nature of this data, each of these problems is non-trivial …
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A distributed CPU-GPU framework for large-scale pairwise alignment
… comparisons of tens of thousands of individual biological sequences. Each such comparison can be performed with the well-known Needleman-Wunsch alignment algorithm. However, with the rapid growth of biological databases, performing all possible comparisons with this algorithm in serial becomes …
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Entropy Measurements and Ball Cover Construction for Biological Sequences
… by the ever increasing amounts of available biological data. Unfortunately, though, these growing databases can be difficult to take full advantage of due to the corresponding increase in computational and storage costs. Entropy scaling algorithms and data structures present an approach that …
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Analysis of variation in protein domain families and interfaces
… and adaptation, and key in a majority of biological processes. A computational framework, ProIntVar, was developed for mapping SNPs onto the structures to allow the features of variation at domain-domain and domain-ligand interfaces to be studied. ProIntVar allows the systematic analysis …
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Semi-automated reconstruction of biological networks based on a life science data warehouse
The progress in the area of biological research in recent years leads to a multiplicity of different databases and information systems. Typically, those data is available via the World Wide Web for further investigation. Usually, biological and life science data that describe different aspects of a …
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PathMeld: A Methodology for The Unification of Metabolic Pathway Databases
A biological pathway database is a database that describes biochemical pathways, reactions, enzymes that catalyze the reactions, and the substrates that participate in these reactions. A pathway genome database (PGDB) integrates pathway information with information about the complete genome of …
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In silico systems analysis of biopathways
… produced; a number of specific genetic/metabolic databases and computational systems have been developed, which makes it possible for biologists to perform in silico analysis of metabolism. With experimental data from laboratory, biologists wish to systematically conduct their analysis with an …
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Identification of yeast genes involved in sauvignon blanc aroma development
… production in yeast with the mining of several biological databases. Screening of the single-gene deletions revealed 17 genes which caused biologically relevant increases or decreases in volatile thiol production, but none abolished it. The majority of the 17 genes were related to the sulfur and …
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Knowledge bases and stochastic algorithms for mining biological data: applications on A-to-I RNA editing and RNAi
Fino alla seconda metà del Novecento, il rapporto tra la Biologia e l Informatica era molto flebile e i dati venivano generalmente raccolti su materiali deperibili come la carta e stipati in schedari. Questa situazione è cambiata grazie all avvento della Bioinformatica, un campo relativamente …
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Evaluation of Annotation Performances between Automated and Curated Databases of <i>E.COLI</i> Using the Correlation Coefficient
… served as one basis of comparison between these databases because of the limited common terms in the ontology annotations. Translation libraries were used to extend the number of BASys terms that could be compared to the gene ontology terms in EcoCyc. Additional, non-ontology terms and metadata …
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Metabolic engineering and modelling of Escherichia coli for the production of succinate
… list of chemicals that can be produced via biological processes and which may be of great importance to sustain a green chemical industry in the future. Succinate is one of those biochemicals. Today, this compound is synthesised via maleic anhydride, which is produced by a petrochemical …