Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"biological analysis"”.
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Bioinformatic and biological analysis of DNA methylation in the human genome
… the Ph.D. project was to apply bioinformatic and biological methods to further the understanding of the properties of DNA methylation in the human genome. To assist interpreting results from global methylation assays, a bioinformatics analysis of the properties of methylation-sensitive restriction …
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DEVELOPMENT OF A REFERENCE METHOD FOR THE ABSOLUTE MEASURING OF FLUORESCENCE IN BIOLOGICAL ANALYSIS
The research presented here was aimed to develop a method traceable to SI to compare the absolute fluorescence intensity measured by different instruments. This is due to the fact that the most common instruments use arbitrary measurement units. Each measure strictly depends on the technical …
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Biochemical and cell biological analysis of the mechanism of RNA interference in human cells
RNA-Interferenz (RNAi) wird in menschlichen Zellen durch kurze, aus 19-24 Basenpaaren bestehende, interferierende RNA (siRNA) Duplexe ausgelöst, welche die doppelsträngigen Vorläufer der endogenen microRNAs (miRNAs) imitieren. Einzelsträngige siRNAs und miRNAs werden in Argonaute-Proteine …
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Enabling tools for biological analysis : technologies for the study of protein dynamics, detection and interaction
The study of proteins in biological systems requires a comprehensive approach: investigating dynamics, interaction and identification. This thesis will examine several technological approaches we have developed to address these needs. To enable the study of the dynamics of biological systems, we …
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The physico-chemical and biological analysis of microbial biosurfactants (BSs) for applications towards cancer therapies, wound healing dressings and drug delivery
… complexities, there is limited physico-chemical analysis relevant to their drug delivery applications. The aims of this research are the systematic investigation of free BSs in cancer therapy as well as the formulation of free BSs and niosomes encapsulating BSs incorporated into lyophilised …
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Microfluidic technology for cellular analysis and molecular biotechnology
… has emerged to offer an ideal platform for biological analysis of a low number of cells. The technological advances in microfluidics have allowed both forming of valves, mixers and pumps and integrating of optic and electronic components into microfluidic devices to construct complete and …
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CMoS lab-on-a-chip devices for individual cell biology
… in a more efficient way specific chemical or biological analysis protocols which are usually carried out with traditional laboratory equipment. In this application area, CMOS technology has the potential to integrate LOAC functionalities for cell biology applications in single chips, e.g. …
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Large core polymer optical backplanes for fluorescence detection
… parameters such as dissolved oxygen or pH in biological systems without disturbing a biological system's equilibrium. Recently, there has been a drive to provide biological analysis tools in a compact form, resulting in arrays of miniature devices which can perform multiple functions in …
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SEA: a novel computational and GUI software pipeline for detecting activated biological sub-pathways
… different pathways using differential expression analysis. Unfortunately, they do not adequately capture the relationships of the genes amongst one another. Structure Enrichment Analysis (SEA) thus seeks to take biological analysis to the next level. SEA accomplishes this goal by highlighting for …
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Bioeconomics Of Invasive Species: The Gypsy Moth
… dissertation. I would like to integrate economic analysis and biological analysis in this dissertation to provide a framework for bioeconomic research. I also want to study the spatial nature of the biological invasion process and design spatial policies to target invasive species. Computational …
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Detection and significance of blood in firearms used in contact gunshot wounds
… was being used to assist the forensiometric analysis of fatalities, a study was undertaken whereby weapons used to inflict fatal contact gunshot wounds in victims presenting at the Pretoria MLL, were requested for biological analysis during the period June 2002 to June 2003. Of the 123 cases …
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Single-Cell Language Model for Transcriptomics & Cell Type Annotation
… datasets continue to grow in size and biological complexity, current models for cell type annotation remain limited in their generalizability and are often evaluated on only a small fraction of the standardized cell types defined in modern ontologies. Current state-of-the-art models for …
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Evaluating the use of manganese-oxidizing bacteria in surface water treatment plants
… MOB are difficult to identify with current biological analysis techniques and comprise small percentages of the total microbial population. MOB have demonstrated potential for use in surface water treatment plants, but further research is needed before this application is fully feasible.
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Notopleural Mutations Enhance Defects In Imaginal Disc Epithelial Morphogenesis And Macrochete Elongation Associated With Mutations in the Stubble-Stubbloid Locus
… of leg and wing epithelia. Genetic and cell biological analysis indicate a role for Stubble in actin cytoskeletal dynamics and cell shape changes in developing epithelia and bristles. Previously reported genetic interactions between Stubble and the Rho1 signaling pathway suggest Stubble …
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Integrated optical surface plasmon resonance for electrochemically addressed layers
… and electrochemical technique for similar analysis. The IOSPR device performed better with 10% change in transmittance in comparison to a change of 1% reported for reflectance measurements. Comparisons were also made with those predicted by a numerical waveguide model. The feasibility of …
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Modeling, simulation, and fabrication of a PZT valveless micropump
… of the most important elements in a micro-total analysis system used for rapid chemical and biological analysis. To date, different kinds of micropumps have been designed, fabricated, tested, and implemented. Among them, a PZT valveless micropump is receiving increasing attentions due to its …
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Microbiota regulate short chain fatty acids and influence histone acylations in intestinal epithelial cells.
… I have achieved this through a combination of biological analysis of the effects of treatment with HDAC inhibitors and in vitro analysis of purified proteins, which enabled determination of kinetic parameters. When investigating how SCFAs could influence histone acylations in vivo, I identified …
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A study of micromachined displacement pumps for vacuum generation
… components in miniature systems for chemical and biological analysis. Miniature sensors and analyzers are normally operated at the pressure range lower than a few millitorr. We are developing a micromachined vacuum pump that is comprised of a mechanical rough pump integrated with micromachined …
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Identification of novel components that connect cellulose synthases to the cytoskeleton
… genetics together with advanced co-expression analysis, we identified pom2 as a cellulose deficient mutant. Map- based cloning revealed that the gene locus of POM2 corresponded to CELLULOSE SYNTHASE INTERACTING 1 (CSI1). Intriguingly, we previously found the CSI1 protein to interact with the …
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