Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"bioisosterism"”.
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Semi-synthesis and evaluation of fusidic acid derivatives as potential antituberculosis agents
… acid for tuberculosis by employing prodrug and bioisosterism approaches through structural modifications at the C-3, C-11 and C-21 positions of the drug.
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Síntese de novos adutos de Morita-Baylis-Hillman com potencial atividade biológica.
… work was designed using the concept of classical bioisosterism where isoelectronic OH groups were replaced by the CH3 group, aimed at finding a relationship between the lipossolubility of the adducts Morita-Baylis-Hillman (AMBH) and its biological activity. Was developed in this work, synthetic …
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Siliciumorganische Wirkstoffe : Synthese und pharmakologische Eigenschaften siliciumhaltiger Muscarin-, Dopamin- und alpha1-Rezeptor-Antagonisten sowie Ca2+-Kanal-Blocker
Im Rahmen der vorliegenden Arbeit wurden neuartige siliciumhaltige Muscarinrezeptor-Antagonisten, Dopaminrezeptor-Antagonisten, Ca2+-Kanal-Blocker sowie alpha1-Rezeptor-Antagonisten synthetisiert, welche Sila-Analoga (C/Si-Austausch) bekannter organischer Pharmaka darstellen. Die C/Si-Analoga …
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Synthesis of sila-analogs and silicon-containing derivatives of drugs and development and application of the Si-2,4,6-trimethoxyphenyl moiety as a novel protecting group in organosilicon chemistry
The present work describes the synthesis of sila-venlafaxine, disila-bexarotene, disila-AG-045572 (disila-CMPD1), a series of silicon-based allosteric modulators of muscarinic receptors, and a partial synthesis of sila-gabapentin. Crystal structure data of rac-sila-venlafaxine hydrochloride, …
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Studien zur C/Si-Bioisosterie
Im Rahmen der vorliegenden Arbeit wurden Beiträge zur C/Si-Bioisosterie und zur asymmetrischen Synthese neuer siliciumhaltiger alpha-Aminosäuren geleistet. Im Vordergrund der Untersuchungen stand die Entwicklung neuer präparativer Methoden zur Darstellung siliciumhaltiger Wirkstoffe und die …