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Showing 1 to 20 of 30 for “"bioinorganic chemistry"”.
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Bioinorganic Chemistry of the Human Host-Defense Protein Calprotectin
… Individual chapter summaries follow. Chapter 1: Bioinorganic Chemistry of the Host Pathogen Interaction. Transition metal ions are required for all forms of life. During the course of infection, pathogenic microorganisms must acquire transition metals from the host. Three metals of interest from …
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Two Methodologies in Pursuit of the Elucidation of Copper (II)—Centered Bioinorganic Chemistry
… to this redox potential. While CuII -centered biochemistry has been studied for years, mechanistic details in certain CuII -centered redox reactions remain unresolved. This study presents two methodologies for studying natural systems with known CuII -centered redox capabilities in order to better …
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Polyoxomolybdates with emergent properties
Coordination chemistry especially of the transition metals is an important area of chemical research as it shows tremendous interdisciplinary relevance, e.g. for catalysis and for bioinorganic chemistry including even aspects of medicine regarding therapy as well as diagnosis. In this context, …
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A developed metallomics method reveals the biochemical fate of Cd2+ and Hg species in erythrocyte lysate
… are urgently needed to gain new insight into the bioinorganic chemistry of non-essential metal species in the human body. To this end, a metallomics method was developed to probe the interaction of Cd2+, Hg2+, CH3Hg+ and thimerosal in the erythrocyte based on the direct analysis of erythrocyte …
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Nitric oxide reactions of bio-Inspired zinc and cobalt complexes
Chapter 1. Bioinorganic Chemistry of Nitric Oxide and of Some of Its Targets The redox-active nature of nitric oxide (NO) regulates the chemistry and roles of NO in biology. The interactions of NO with nitric oxide synthases, metallothioneins, and cobalamin-containing enzymes are discussed. …
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The creation and interpretation of an elemental database for Chinese traditional herbal remedies
… have been organic. Given the emerging area of bioinorganic chemistry/medicinal inorganic chemistry, it is now recognized that small molecule inorganic species play an equally important role in biology. In this regard, there has been very little research, if any, conducted into the search for …
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Investigation of zinc metalloneurochemistry with fluorescent sensors based on fluorescein platforms
Chapter 1. CoordinationChemistry for the Neurosciences Metal ions are integral components of numerous enzymes and proteins. Although the field of bioinorganic chemistry has not focused on the brain and central nervous system, metal ions are vital to many neurological functions and are implicated in …
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New insight into the coordination and reactivity of hetero-substituted maltol and method development for complex mixture analysis of asphaltene.
… its hetero-substitutions have a wide variety of bioinorganic applications. However, the latest addition to this family of molecules, 3-hydroxy-2-methyl-4H-pyran-4-selenone (selenomaltol), had not previously had its metal complexes characterized. To remedy this, transition metal complexes were …
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Ameliorating the toxic side-effects of cisplatin by systematically modulating its metabolism in human plasma with chemoprotective agents
… of plasma allowed to gain more insight into the bioinorganic chemistry that unfolds in the absence of plasma proteins under physiologically similar conditions. Analysis of a PBS-buffer sample that was spiked with CP and STS by X-ray absorption spectroscopy revealed the presence of [Pt(S2O3)4]6- …
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The in vitro selection and biochemical characterization of metalloDNAzymes
… and thus are an active area of research in bioinorganic chemistry. Additionally, DNAzymes have proven their ability to distinguish between various metal ions with as high as million-fold selectivities. Such selectivities between metal ions with similar charge, ionic radii, and other …
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Engineering novel tandem reactions using organometallic catalysts and metalloenzymes
Organometallic chemistry and bioinorganic chemistry are two prominent sub-disciplines of chemistry. Complexes of the transition metals are prominent components of both disciplines. On the one hand, considerable efforts in transition-metal catalysis have culminated in practical and efficient …
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Oxyanion reduction in a non-heme iron system
… systems and the work of others in the area of bioinorganic chemistry creating biomimetic systems, our group designed a tripodal ligand platform featuring a secondary coordination sphere. The ligand is tautomerizable, which allows for versatility in both the primary and secondary coordination …
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Platinum Complexes and Zinc Finger Proteins: From Target Recognition to Fixation
<p>Bioinorganic chemistry strives to understand the roles of metals in biological systems, whether in the form of naturally occurring or addition of non-essential metals to natural systems. Metal ions play vital roles in many cellular functions such as gene expression/regulation and DNA …
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Cellular metal ion sensing using DNAzymes
"Metal ions are important elements in biology and are involved in numerous reactions essential for maintaining life on earth. Most commonly, metal ions confer their role as structural elements or catalytic cofactors within metalloproteins. Metalloproteins comprise more than half of all known …
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Expanding the chemistry of a cupredoxin by designing nonnative active sites and using abiological metals
… metals, or cofactors to expand the possible chemistry beyond what can be done in nature. In an effort to explore new electron transfer properties of artificial cupredoxin-like metalloproteins, a mutant of the blue copper protein azurin (Az) was metalated with chromium and its novel properties …
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Reactions of S-nitrosothiols with biomimetic iron complexes and other transition metals
Chapter 1. Bioinorganic Chemistry of Nitric Oxide and S-Nitrosothiols The interplay of nitric oxide (NO), biological thiols, and metals has been a topic of intense study since the discovery of NO as the endothelium-derived relaxation factor. NO is a redox-active diatomic, radical gas that is …
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Small molecule activation and reduction using non-heme iron complexes
In Nature, metalloenzymes are responsible for carrying out a vast array of different reactions. The secondary coordination sphere of these play an intricate role in controlling nuclearity, enhancing substrate selectivity, stabilizing reactive intermediates, and controlling the redox potential of …
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Pyrazole and pyrazolyl palladium(II) and platinum(II) complexes: synthesis and in vitro evaluation as anticancer agents
The use of metallo-pharmaceuticals, such as the platinum drugs, for cancer treatment illustrates the utility of metal complexes as therapeutic agents. Platinum group metal complexes therefore offer potential as anti-tumour agents to fight cancer. This study was aimed at synthesizing and evaluating …
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Kinetic and Spectroscopic Investigation of Structural Influences on Hydrogen-atom Transfer Reactivity of N5-Ligated Oxomanganese(IV) Complexes
High valent iron- and manganese-oxo intermediates perform important hydrogenatom transfer (HAT) reactions in both biological and synthetic systems. There has been extensive characterization of HAT reactivity of enzymatic and synthetic oxoiron(IV) species, and these complexes have been shown to …
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Development and Evaluation of Organometallic Anticancer Drug Candidates
… have led research in Medicinal Inorganic Chemistry to using other precious metals for the design of novel anticancer therapeutics. This work reports on the synthesis and characterisation of a series of organometallic drug candidates based on ruthenium, osmium, rhodium, and iridium, …
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