Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 447 for “"bioinformatic"”.
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MicroRNA cloning and bioinformatic analysis
… Therefore, we developed an experimental and bioinformatics strategy to identify novel miRNA genes. We discovered a total of 75 miRNA genes in the C. elegans genome, and orthologues for a majority of these were computationally identified in the C. briggsae, D. melanogaster or H. sapiens …
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Bioinformatic Approaches to Study Mitochondrial DNA Heteroplasmy
Mitochondria serve as signalling centres; they are primarily responsible for producing cellular energy and contain multiple copies of their own small, circular DNA, known as mitochondrial DNA(mtDNA). Mutations in mtDNA can be maternally inherited or somatic, when they occur after fertilisation. …
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Integrating bioinformatic approaches to promote crop resilience
… these systems. Here we report the integration of bioinformatic and statistical tools to leverage high-throughput sequencing to 1) develop a machine learning approach to determine factors impacting transcriptome assembly and quantitatively evaluate transcriptome completeness, 2) dissect complex …
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Bioinformatic analysis: Retroposon sequences containing multiple putative endonucleases
Among the retroposons, the source of the endonuclease activity is known to be variable. We investigated whether any retroposon genomes encode potential multiple endonuclease functions. Amino acid alignments were generated to reveal the presence of the characterized ordered-series-of-motifs (OSM) …
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Bioinformatic studies of small disulphide-rich proteins (SDPs)
… bridges in SDPs were investigated using bioinformatic approaches. The systematic analyses suggested that cysteine signature can facilitate the detection of distantly related homologs or convergently evolved structures. Based on the rules derived from the analyses, a software pipeline were …
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Bioinformatic identification and characterization of cytokinetic regulators in Mtb
… involved in cell division control in Mtb. Bioinformatic analysis identified rv1708 as encoding a MinD-like protein putatively involved in septum placement, and rv2216 as encoding a potential SOS-associated cell division inhibitor, SulA. Bioinformatic-based assessments of orthology revealed …
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From Prohormones to Neuropeptides: Mass Spectrometric and Bioinformatic Approaches
… After deducing the neuropeptide genes through bioinformatic and mass spectrometric approaches, the neuropeptides are predicted with the Aplysia-based algorithms. To verify all predictions, the peptide sequences are confirmed by electrospray quadrupole mass spectrometry (ESI-Q) TOF-MS. Employing …
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Bioinformatic methods for analyses of epigenome and RNA interactome
The sequenced genetic codes for multiple species have provided great sources for understanding how a single genome can give rise to a complex organism. However, only a small percent of mammalian genome could be identified as protein-coding genes. Our understanding of the genome is far from …
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Do RNA-dependent polymerases share common ancestry? A bioinformatic approach
Bioinformatics is the use of computational methods to perform hypothesis-driven research that generates new knowledge from existing biological databases. For any bioinformatic analysis, it is important that the most accurate method(s) be used. The first portion of this thesis is a comparative …
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Bioinformatic Analysis of the Interaction Of EVC And EVC2 Proteins
<p>Protein to protein interactions are significant to various biological processes, functioning, and the regulation of cells and organisms. Proteins perform essential cellular tasks and often work together in complexes, enabling specific functions like enzymatic activity, signal transduction, DNA …
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Functional genomic study and bioinformatic analysis on natural bioactive peptides
An extraordinary diverse components of animal toxins have emerged along with the long-term evolution of animals, which have unique functions that protect them to survive in the wild. Specifically, the granular glands of amphibians contain multiple chemical compounds, among which, peptides are one …
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Sequence features affecting translation initiation in eukaryotes: A bioinformatic approach
Sequence features play an important role in the regulation of translation initiation. This thesis focuses on the sequence features affecting eukaryotic initiation. The characteristics of 5' untranslated region in Saccharomyces cerevisiae were explored. It is found that the 40 nucleotides upstream …
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Bioinformatic methods for the analysis of genetic variability and regulation
Next-generation sequencing (NGS) technologies have put within our reach several biological inquiries. In this thesis, we exploited NGS data to address questions related to how cell's genetic and epigenetic makeups give rise to phenotypic traits and regulatory processes. We started analyzing the …
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Bioinformatic methods in mammalian genomics: applications towards conservation and health
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-20 without embargo terms
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Bioinformatic tools for single-cell data analysis in clinical studies
… parallel efforts to develop and apply new bioinformatic techniques to generate robust findings from single-cell data The advances are especially pertinent for small clinical studies in which low sample numbers are limiting In the first part of the thesis, two classes of methods are …
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Bioinformatic and biological analysis of DNA methylation in the human genome
… The aim of the Ph.D. project was to apply bioinformatic and biological methods to further the understanding of the properties of DNA methylation in the human genome. To assist interpreting results from global methylation assays, a bioinformatics analysis of the properties of …
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Identification of gene expression changes in human cancer using bioinformatic approaches
The human genome contains tens of thousands of gene loci which code for an even greater number of protein and RNA products. The highly complex temporal and spatial expression of these genes makes possible all the biological processes of life. Altered gene expression by mutation or deregulation is …
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Development of Bioinformatic Tools and Procedures to Computationally Support DNA Barcoding
This thesis reports the development of several new and/or improved pipelines for investigating nucleotide alignments as part of DNA barcoding and DNA metabarcoding. In addition, the existing barcode regions were investigated to discover if possible mini-barcodes could be used in order to improve …
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Biosynthetic and bioinformatic investigation of RiPPs with radical SAM-installed crosslinks
… has expanded greatly since. However, previous bioinformatic analyses have been limited, requiring extensive manual curation to identify cyclophane precursors. In Chapter 3 I discuss the generation of a RODEO module (a genome mining tool) to enable automatic scoring and classification of rSAM …
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