Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 493 for “"biogenesis"”.
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Lysosome biogenesis during osteoclastogenesis
… been learned about different aspects of lysosome biogenesis. The selective phosphorylation of mannose residues on lysosomal enzymes, in conjunction with specific receptors for the mannose-6-phosphate recognition marker, has been found to be largely responsible for the targeting of newly …
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Biogenesis of Multipass Membrane Proteins
… and mechanisms of multipass membrane protein biogenesis. Biochemical reconstitution combined with genetic and chemical perturbations showed that the first two TMDs of most multipass proteins with a cytosol-facing N-terminus are inserted by a Sec61-independent mechanism. Instead, this insertion …
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THE TRANSCRIPTIONAL PROGRAM OF GOLGI BIOGENESIS
… However, transcriptional contribution to Golgi biogenesis remains poorly understood because of the lack of a robust method to induce large-scale production of new Golgi units. In this study, we developed an enzyme-based approach to eliminate the Golgi apparatus, triggering the de novo formation …
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SR proteins in microRNA/mRNA biogenesis
… involvement in regulating microRNA/mRNA biogenesis and their own expression. </p><p>Negative feedback regulation is a common mechanism maintaining the steady-state level of SR proteins (i.e. SC35 and SRp20), and several mechanism may be involved. In order to test if miRNAs are also …
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Mechanisms of multipass membrane protein biogenesis
… human diseases observed upon disruption of their biogenesis. This thesis aims to describe our recent contributions to the understanding of how membrane proteins are made at the endoplasmic reticulum (ER), the primary site of IMP biogenesis in the cell. Although IMPs are defined by a single …
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The biogenesis of erythropoietin during inflammation
Anaemia frequently accompanies chronic inflammatory diseases like rheumatoid arthritis and cancer. It is postulated to result primarily from the suppression of erythropoiesis by inflammatory cytokines. A contributing factor could be the inhibition of erythropoietin synthesis which may also be …
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Biogenesis and Traffic of the Potassium Channel
… plasma membrane. This work examines aspects of biogenesis and traffic of the Shaker voltage-gated potassium channel. Shaker is an oligomeric, polytopic membrane protein and, as such, its biogenesis begins at the endoplasmic reticulum (ER). I have studied (i) targeting of Shaker to the ER and …
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Biogenesis of Membrane-Bound and Secreted Immunoglobulins
<p>The specificity of the immune response to antigen was first appreciated by the study of serum immunoglobulins (Igs). The subpopulation of lymphoid cells that synthesize these molecules are so defined as members of the B lineage; the end-stage cell type of this lineage is the plasma cell. The …
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Molecular analysis of vesicle biogenesis during autophagy
Autophagy in Saccharomyces cerevisiae comprises diverse processes that transport cytoplasm and even organelles into the vacuolar lumen for degradation. During macroautophagy out of the pre- autophagosomal structure (PAS) autophagosomes are formed that fuse with the vacuole for degradation. During …
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Biogenesis of Y RNA–derived small RNAs
… of which originate from longer RNAs. Here, the biogenesis of sRNAs derived from the non-coding Y RNAs (YsRNAs) was characterised as a model for understanding this emerging class of sRNA fragments. Y RNAs are highly conserved, 100 nt long molecules involved in DNA replication which bind to the …
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Biogenesis and Function of the Mitochondrial Ribosome
… I present results of my PhD research into the biogenesis and function of the human mitochondrial ribosome. The mammalian mitochondrial ribosome (mitoribosome) is one of the largest ribonucleoprotein complexes in the cell, with the overall molecular mass of the fully assembled 55S monosome being …
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Switching the Fate of mRNAs for Mitochondrial Biogenesis
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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The Biogenesis of Peroxisomal Catalase in Rat Liver
<p>Rat liver peroxisomal catalase was purified to homogeneity. The starting material was purified peroxisomes, The purity of the final preparation was judged by Sephadex G-200 chromatography, SDS gel electrophoresis, spectral analysis, and immunochemical means. Two sera containing anticatalase …
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Mechanisms and Evolution of Mitoribosomal Small Subunit Biogenesis
… accuracy and processivity. During ribosome biogenesis, ribosomal proteins and a multitude of additional assembly factors, of which there are over 200 in yeast, orchestrate rRNA processing, folding, and modification. While the vast majority of proteins are made by cytoplasmic ribosomes in …
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On co-transcriptional splicing and U6 snRNA biogenesis
… whether Pol II has a functional role in the biogenesis of the U6 snRNA, which is the RNA part of the U6 snRNP involved in splicing. Pol III had been shown to transcribe the U6 snRNA gene, but ChIP experiments revealed that Pol II is associated with all the active U6 snRNA gene promoters. Pol …
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Regulation of mitotic spindle biogenesis in budding yeast
Assembly of the mitotic spindle is critically dependent on centrosome duplication (spindle pole body or SPB in yeast), separation of sister centrosomes and microtubule dynamics. Activation of Cdc28 (Cdk1) by tyrosine-19 dephosphorylation is essential for centrosome separation, the first step in …
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Mechanisms of Multivesicular Body Biogenesis and Exosome Release
Exosomen sind kleine Vesikel mit einem Durchmesser von ca. 50-100 nm, die von vielen Zellarten sezerniert werden und verschiedene interzelluläre Signalprozesse koordinieren. Nach der Fusion von multivesikulären Endosomen (MVE) mit der Plasmamembran werden die intraluminalen Vesikel (ILV) als …
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The Biogenesis of Small Interfering RNA in Neurospora Crassa
… damage. Our results suggest that the small RNA biogenesis machinery is recruited specifically to the repetitive loci after homologous recombination, which may result in the formation of aberrant DNA structures. dsRNA not only triggers the RNAi pathway, but also initiates a signaling cascade that …
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The Regulation of Microrna Biogenesis By Ribosome-Interacting Proteins
… Many of the proteins involved in miRNA biogenesis share a common role in ribosomal RNA regulation. Here we characterize two ribosome-associated proteins that are important for miRNA biogenesis. In one study, we identified nucleolin as a positive regulator of pri-miR-15a/miR-16-1 …
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Biogenesis of iron-sulfur clusters and intracellular iron metabolism
Iron-sulfur ([Fe-S]) clusters represent one of natures most diverse and ubiquitous protein prosthetic groups. [Fe-S] proteins are integral for diverse biological processes. Reconstitution of apo-proteins can occur by exogenously adding excess iron and sulfide. However, due to the toxicity of iron …
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