Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"biofluids"”.
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Metal-ions in biofluids-aluminium in-vitro studies
[Page ii missing] The stoichiometric stability constants of aluminium III of inorganic phosphates and adenine nucleotides have been determined at ionic strength. I = 0,15 and a temperature of 25°C using glass electrode potentiometry and computer modelling. The protonation sequence for …
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Metal ion equilibria in biofluids - copper and rheumatoid arthritis
A computer model of blood plasma has been used to evaluate the factors affecting the ability of a ligand to increase the low molecular weight copper pool in vivo. The justification for using this speciation approach is based on the assumption that the low molecular weight copper complexes are …
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Single-molecule studies of alpha-synuclein and abeta in Parkinson’s disease derived biofluids
… can detect αS and Aβ aggregates in vitro and in biofluids. With this, we identified a biomarker in a small cohort study in human blood serum by quantifying the ratio of these two proteins. Using single-molecule total internal reflection fluorescence imaging, super-resolution, and high-resolution …
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Translational Studies of Acute and Chronic Traumatic Brain Injury: Molecular Profiling of Tissue and Biofluids
Traumatic brain injury (TBI) is a leading contributor to the global burden of disease. Despite the growing awareness of TBI and years of research into biomechanics and pathophysiologic mechanisms, there is still a lack of effective therapies to treat patients. To better understand the genomic …
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DEVELOPMENT AND APPLICATION OF NOVEL COMPUTATIONAL INTELLIGENCE TECHNIQUES TO THE MULTIVARIATE ANALYSIS OF METABOLOMICS BIOFLUIDS DATASETS
The present decades have witnessed major advances in the development and applications of Computational Intelligence Techniques (CITs), which are commonly associated with metabolomics and omics analyses related to diseases diagnosis. This includes, amongst others, research work performed on …
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A study of a flapping flag in viscoelastic fluids and its implications for micro-scale swimming in biofluids
Biological cells and organisms employ a different method of propulsion when in viscous, viscolelastic fluids rather than Newtonian fluids. By studying the dynamics of a flag under a flow of a viscoelastic fluid, we hope to better understand the swimming dynamics in these biological fluids. A …
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Sensitivity and Species Specificity of Bisulfite Modification and Pyrosequencing Technology Used to Identify Tissue-Specific DNA Methylation Patterns in Common Biofluids Foudn in Crime Scenes
… nature of the crime. Identifying the different biofluids found at a crime scene can help shed light on these aspects of forensic casework. Recently, DNA methylation has been used as a means of identifying biological materials, as opposed to conventional protein/enzyme based methods. DNA …
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Different approaches to biomarker research for ALS: in search of novel neuronal markers associated with extracellular vesicles
… various strategies were implemented to study biofluids collected from ALS patients, aiming to identify protein-level alterations that may suggest pathways deregulated in disease conditions. First, plasma samples from ALS patients and controls were analyzed using the Olink platform. Four …
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Exosomes and miRNAs in disease pathogenesis and opportunities for molecular targeting
… with the exosome function of different biofluids. The aim of this research was to elucidate the role of exosomes/EVs as well as miRNAs in the pathogenesis of different diseases, including alcoholic liver disease, hepatitis C, and cancer. This knowledge may lead to the development of …
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Motion at low Reynolds number
… at low Reynolds numbers at the crossroad between biofluids and microfluids. Here we address questions regarding locomotion of micro-swimmers, transport of nutrient around micro-organisms as well as mixing and heat exchange inside micro-droplets of water. A general framework for the investigation …
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An Electrochemical Sensor Development Platform: Applications of System Identification to Biological Sensing in Evolving Fluids
… the growth of microorganisms within these biofluids is of key importance from scientific roles identifying pathogens and their biochemical behavior to industrial applications in food safety, healthcare, and pharmaceuticals. Compact, low-cost electrochemical sensors that monitor …
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Development and validation of ultra-high performance liquid chromatography-tandem mass spectrometry methods for screening of selective androgen receptor modulators in urine and blood
… of emerging SARM compounds in a range of biofluids collected from different animal species. <br/><br/>Considering that urine and blood are generally the biological matrices of choice regulated by both anti-doping testing and drug residue monitoring programmes, three semiquantitative …
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Exploring metabolomics through NMR: from early life to aging
… heterogeneity is substantial, and non-invasive biofluids such as urine provide a complex yet informative window into both systemic physiology and developmental processes, including renal maturation. These features make early life an ideal, though challenging, context in which to test the …
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Development Of Isotags For Nmr Based Metabolite Profiling And Applications
… hundreds of quantifiable metabolites in biofluids using NMR spectroscopy or mass spectrometry. In this thesis we show improved sensitivity and resolution of NMR experiments imparted by 15N and 13C isotope tagging which enables the accurate analysis of plasma metabolites. To date, isotope …
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Development of novel techniques for monitoring anti-oxidant thiols
… The variation in their concentration within biofluids is widely acknowledged as a useful diagnostic gauge as to the degree of oxidative stress that an individual may be experiencing. The main problem, from a clinical perspective, is the lack of a suitable procedure for monitoring their …
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Materials for bioimplantable / bioresorbable electronics
… silicon and thermally grown silicon dioxide in biofluids for their provisioned importance as a thin film water barrier in implantable flexible electronics. The different materials dissolution rates in silicon and its oxide provide materials design options in device construction depending on the …
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Towards Urine Sensing in Plasmonic Nanogaps
Molecular sensing of biofluids has great potential for continuous health monitoring. Urine is of particular interest as it is available in large quantities and can be collected non-invasively. Urine contains thousands of metabolites and potential biomarkers at trace concentrations. Surface-enhanced …
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Quantitation of Anti-Infectious Disease Molecules Utilizing Paper Spray Mass Spectrometry
… to perform because measurements occur in biofluids. Rapid and robust methods are necessary to quantify antimicrobial agents at the institutional level to guide patient care toward improved outcomes in serious infection. Paper spray ionization (PS), an emerging ambient ionization technique …
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Antifouling and Antithrombogenic Ultrathin Surface Chemistry for Bioanalytical and Biomedical Applications
… detecting target analytes in real-world biofluids - exploiting the transducing technology of the ultra-high frequency electromagnetic piezoelectric acoustic sensor (EMPAS) system - as potential clinical assay alternatives to current screening/diagnostic tests. Biosensing platforms …
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Hydrogel-based Graphene Electrochemical Tattoo (GECT) Sensor for Tyrosine Sensing in Sweat
… The rise in alternative sensors that use other biofluids rather than blood for diagnostics was an approach to address this problem. Tears and saliva are popular alternatives; however, they also face specific challenges in terms of continuous monitoring and comfort. Meanwhile, sweat offers …
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