Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"biofabrication"”.
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Modelling the neural microenvironment through biofabrication technologies
L'abstract è presente nell'allegato / the abstract is in the attachment
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Versatile multi-component (bio)ink platform for advanced biofabrication
The thesis aims to advance tissue engineering through bioprinting, addressing the need for innovative solutions to restore tissue function and tackle organ shortages. Bioprinting, which integrates 3D printing with biological materials to create "bioinks," has significant potential but is hindered …
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Biofabrication of a Heart Wall Section using the FRESH Bioprinting Method
This dissertation addresses the challenge of bioprinting cardiac wall tissues. It focuses on three different aspects. The first is around materials that mimic the different cardiac wall tissue layers by testing the different materials pre- and post-crosslinked for their characteristics and …
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Biofabrication technologies enabling vascularization of organ- scale engineered tissues for clinical translation
Transplantable engineered organs could one day offer life-saving treatments for patients with end-stage organ failure. However, producing hierarchical vascular networks that sustain the viability and function of cells within human-scale organs after implantation remains a major challenge. …
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Biofabrication of muscular and neuronal in-vitro tissue for multi-cellular engineered living systems
… activity of motor neuronal networks, the biofabrication of neural tissue containing motor neurons, and the redesigning of previous muscle-based walking robots for higher force generation. First of all, the ability to uncover in-vitro methods to “reprogram” neural networks responsible for …
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Electromagnetic Control of Biological Assembly
We have developed a new biofabrication process in which the precise control of bacterial motion is used to fabricate customizable networks of cellulose nanofibrils. This work describes how the motion of Acetobacter xylinum can be controlled by electric fields while the bacteria simultaneously …
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3D Bioprinting of Advanced Bioinks for Tissue Engineering Applications
… scaffolds, and growth factors. Among various biofabrication methods, tremendous attention has been devoted to the recently emerged three-dimensional (3D) bioprinting technology for the fabrication of functional tissue-engineered scaffold loaded with cells due to its ability to assemble complex …
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BioConstructs : methods for bio-inspired and bio-fabricated design
… production by bacteria to a fabrication process (biofabrication). This fabrication method combines digital tools and technologies with material production by a living biological system. The long-term objective is to use cellulose-producing bacteria to develop an additive manufacturing technique …
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Form from within : scaling up self-constructing biological architectures through a novel application of synthetic morphogenesis
In this thesis, I introduce a novel biofabrication method Architectures from Staged Self-assembly of Morphogenetic Building Elements (ASSEMBLE), that brings about self-constructing biological structures at the architectural scale by merging scientists' newly developing ability to control the …
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Biomanufacturing of Bacteria-Mediated Drug Delivery Systems and Investigation of Their Interaction with the Tumor Microenvironment
… of both treatment modalities. We explore biofabrication of our bacteria-nanoparticle conjugates called NanoBEADS (Nanoscale Bacteria Enabled Autonomous Drug Delivery Systems) and their interaction with the TME. Specifically, (1) we investigate the effects of two bacteria-NP conjugation …
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THE ROLE OF INNERVATION IN ENGINEERED MUSCLE
… developmental muscle biology, neurosurgery, and biofabrication offers a promising path forward for constructing implantable muscle tissues capable of restoring contraction, perfusion, and neuromuscular connectivity. In this work, we apply these interdisciplinary strategies to develop a …
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Data-driven approaches for complex systems: leveraging machine learning, materials science, and manufacturing for new biomedical technologies
… minimally-invasive, patient-specific, in situ biofabrication.
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Adaptive fabrication of biofunctional decellularized extracellular matrix niche towards complex engineered tissues
… (ECM) in vitro has been an ongoing challenge in biofabrication. In this study, I present a biofunctional ECM-mimicking protein scaffold with tunable biochemical, mechanical and topographical properties. This scaffold, formed by microfibres, displays three favorable characteristics as a cell …
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Biohybrid Peripheral Neural Interfaces: Combining Cell Transplantation and Flexible Electronics for Functional Neurological Restoration
… a strong bonded hydrogel that allows for biofabrication on top of flexible electronics. Finally, I showed long term recordings from my biohybrid neural interfaces in a chronic rat peripheral nerve injury model for 30 days duration. These findings strongly suggest that biohybrid peripheral …
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Towards Fibre-Integrated Hydrogels: A New Approach for 3D Hydrogel Printing & A Study of Single Cell-Microfibre Interactions
Recent advances in biofabrication have unveiled opportunities to build up biomimetic scaffolds and architectures for applications ranging from tissue engineering to bioinspired soft robotics. The structural and functional analogues of ECMs could be seen to structurally exist with two functional …
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Novel Advances in Bioprinting Based on the Mechanical Design and Optimization of Open-source Systems
… biomaterials and several cells types in a single biofabrication session. This is a significant challenge, and, to tackle that, we must focus on the complex relationships between the printing parameters and the print resolution. We proposed a standard methodology to quantify the print resolution of …
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NUTRITIONAL AND FUNCTIONAL CHARACTERISATION OF ALTERNATIVE FEED AND FOOD INGREDIENTS: EMPHASIS ON HEMP-BASED PRODUCTS, CO-PRODUCTS, MICROALGAE AND CULTURED MEAT
… alternatives to fetal bovine serum, scalable biofabrication methods, and the integration of waste-derived components to support cell proliferation and differentiation. These objectives collectively aimed to advance sustainable, ethical, and innovative practices in the agri-food sector. Hemp …
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Design and fabrication of next-generation biological soft robotics
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-05-01
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