Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 104 for “"bioenergetic"”.
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Bioenergetic neuroprotection in experimental glaucoma
… and society levels. This thesis investigates bioenergetic neuroprotection in experimental glaucoma and specifically the effects of pyruvate supplementation in facilitating neuroprotection or recovery of compromised, but not dead, RGCs. The thesis consists of two related but independent …
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Bioenergetic Evaluation of Site-specific Keloid and FKN Fibroblasts
… whether the disease phenotypes were linked to bioenergetic changes at a cellular level in these two conditions. Patient-derived tissue biopsies were used for fibroblast cell culture models, in which cell analysis was carried out to assess phenotype and different parameters of bioenergetic …
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Bioenergetic and Metabolic Signatures of Maternal Overnutrition in the Offspring Heart
… in offspring cardiac alterations, however these bioenergetic and metabolic phenotypes remain poorly defined. This thesis aimed to investigate cardiac mitochondrial bioenergetics and metabolism in the offspring of overnourished mothers using mouse and sheep models, alongside other tissues relevant …
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Bioenergetic and ecological consequences of diet variability in Atlantic croaker Micropogonias undulatus
… previously detected. Thus, I investigated the bioenergetic consequences of secondary piscivory to the distribution of croaker, to the condition of individuals within the population and to the ecosystem. Generalized additive models revealed that the biomass of anchovy explained some of the …
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Electrochemical and genetic tools for analysing and engineering bioenergetic processes in cyanobacteria
… advancing the understanding and engineering of bioenergetic processes in cyanobacteria.
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A bioenergetic simulation model of orchard populations of the pine vole (Microtus pinetorum)
A mechanistic model was developed. to simulate apple orchard populations of the pine vole (Microtus pinetorum) in southwest Virginia. Population. size and demographic parameters were modeled on a weekly basis as functions of bioenerqetic status. Forage gross energy availability, digestibility, …
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Bioenergetic and functional impacts of glucose, fructose and insulin in endothelial cells:: implications for cardiovascular disease in diabetes
… and 25 mM) for 48 hours and the measurement of bioenergetics, cell function and key endothelial cell mediators compared for HGPC and NGPC cells.<br/>Further complexity was incorporated into the model by partial substitution of glucose with fructose and by the inclusion of insulin. The impact of …
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The impact of high and intermittent-high glucose on ROS generation and bioenergetic metabolism in vascular endothelial cells
… impact of high and intermittent-high glucose on bioenergetic function in HUVECs was assessed, using extracellular flux analysis.<br/>Lastly, the impact of improved glucose control on oxidative stress was retrospectively determined using data from a clinical study of T2DM patients receiving …
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Bioenergetic coupling in P-glycoprotein: determining the relative position, topography and role of transmembrane helices six and twelve
… data implicates TM6 & 12 as mediators of bioenergetic coupling in P-gp. A major issue in attempts to determine the molecular mechanism is the lack of a high-resolution structure of human P-gp in the basal, inwardfacing state. Several crystal structures of murine P-gp in the basal state are …
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Bioenergetic coupling in P-glycoprotein: determining the relative position, topography and role of transmembrane helices six and twelve
… data implicates TM6 & 12 as mediators of bioenergetic coupling in P-gp. A major issue in attempts to determine the molecular mechanism is the lack of a high-resolution structure of human P-gp in the basal, inwardfacing state. Several crystal structures of murine P-gp in the basal state are …
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Life history and bioenergetic modelling of adfluvial-lacustrine coastal cutthroat trout predation in the Capilano Reservoir : implications for endangered steelhead, coho salmon and future holistic watershed management strategies
… This thesis investigates cutthroat predation via bioenergetic modelling and demography, and genetic analysis of hybridization with coastal rainbow / steelhead trout (O. mykiss irideus). The bioenergetics model, based on stomach content analyses, reservoir temperature and growth rates, in …
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Microtubule Regulation of Mitochondrial Bioenergetics in Cardiac and Skeletal Muscles
A novel model of mitochondrial bioenergetic regulation has been proposed whereby microtubules may directly influence the permeability of ADP into the mitochondria to stimulate the production of ATP. Specifically, tubulin, the structural unit of microtubules, physically inserts into the voltage …
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Exploring the Role of Mitochondrial Bioenergetics and Metabolism in Heart Failure
… alterations in mitochondrial fuel metabolism and bioenergetics. As such, there is considerable interest in the delineation of regulatory events involved in the metabolic dysfunction of heart failure. Previous collaborative work identified three metabolic signatures associated with early stage …
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Novologue Therapy Improves Mitochondrial Bioenergetics and Modulates Transcriptome Changes in Diabetic Sensory Neurons
… options. Impaired neuronal mitochondrial bioenergetics contributes to the pathophysiologic progression of DPN and may be a focal point for disease management. We have demonstrated that modulating Hsp90 and Hsp70 with the small-molecule drug KU-32 ameliorates psychosensory, …
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Predatory Impact of Exotic Cladoceran Cercopagis pengoi on the Zooplankton of Lake Ontario
… consumption demand of Cercopagis based on bioenergetic considerations. A comparison of average pre-and post-invasion abundances of Daphnia retrocurva, Bosmina longirostris and Diacyclops thomasi suggests that Cercopagis is having a major effect on zooplankton abundance in the lake. In the …
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Role of metabolic stress in the selective vulnerability of dopaminergic neurons
… dopaminergic degeneration arises primarily from bioenergetic failure and oxidative stress, and that sodium propionate confers neuroprotection by stimulating or sustaining succinate-dependent mitochondrial energy production. This study highlights a mechanistic link between environmental …
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A Multi-Factorial Assessment of Partial Mitochondrial Complex I Impairment in Colorectal Cancer
… I, has emerged as a key determinant of tumor bioenergetics and signaling. This dissertation investigates how partial complex I dysfunction influences CRC tumor growth and whether the impact of this partial disruption depends on the timing of mitochondrial impairment. Using a combination of …
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Cardiac mitochondrial respiration in two rodent models of obesity
… FFA supply decreases cardiac mitochondrial bioenergetic capacity. Furthermore, we also hypothesized that females possess innate cardioprotective programs that will result in enhanced bioenergetic capacity compared to males. We examined our hypothesis employing two rodent models i.e. a) a rat …
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Deficiency in Parkinson's Disease risk gene CD38 as it relates to glial function: dysregulation of astrocyte genes and bioenergetics as a result of CD38 deficiency
… and a second as an ectoenzyme that modulates bioenergetic functions. The particular functions of CD38 are highly relevant to neurodegenerative contexts, as changes in central nervous system (CNS) inflammatory status and means of cellular energy production typically precede pathological …
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