Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 142 for “"biodistribution"”.
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Lutein and α-tocopherol biodistribution in animal models
… mice. In conclusion, we elucidated lutein biodistribution profiles in infant monkeys who were breastfed or formula-fed for six months, as well as one possible mechanism to explain the differential accumulation of lutein in primate retina and brain. In addition, we determined tissue …
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Anti-inflammatory Effects and Biodistribution of Cerium Oxide Nanoparticles
… ROS in vitro and in vivo, and examined the biodistribution and biocompatibility of nanoceria in murine models. Nanoceria was internalized in vitro by macrophages, is non-toxic at the concentrations we investigated, and proteins, mRNA, and oxidative markers of ROS were abated with nanoceria …
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Discovering carotenoid biodistribution pathways: Novel mechanisms and their implications for health
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-03-01 without embargo terms
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Biodistribution of Modified Extracellular Vesicles In Normal and Tumor-Bearing Animal Models
… a drug delivery system is to understand their biodistribution in vivo. In this thesis, we systemically injected modified EVs labeled with the lipophilic dye DiO to both normal and orthotopic-tumor animal models. We harvested the following tissues: blood, heart, lung, spleen, liver, kidney, …
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Enhancing the Biodistribution and Physicochemical Properties of Gold Nanoparticles by Modifying their Surface Characteristics
L'abstract è presente nell'allegato / the abstract is in the attachment
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Investigation of intercellular transport and biodistribution of curcumin across the nasal epithelium in hamsters
… and compared for intercellular transport and biodistribution of the visual probe. Visual probe transport was evaluated in animal groups at 15 and 30 min after inhalation and compared to uninoculated controls and in control animals that received brain homogenate without visual probe. Organs …
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Production and utilization of phytoene, phytofluene, and lycopene tracers for bioavailability and biodistribution studies
… carotenoids was developed, and absorption and biodistribution studies were performed in a relevant animal model, the Mongolian gerbil (Meriones unguiculatus). To enhance 14C-carotenoid production from tomato (Solanum lycopersicum cv. VFNT cherry) in vitro cell suspension cultures were treated …
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An assessment of the biodistribution, persistence, and health impacts of microplastics and nanoplastics in fish
… but first more information is required on the biodistribution, persistence, and subsequent health impacts of microplastics and nanoplastics in organisms. My thesis addresses these key knowledge gaps through a combination of environmental measurements and laboratory experiments. I first reviewed …
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Role of vascular remodeling in the accumulation, clearance, and biodistribution of biomolecular factors in melanoma
Local inflammation within the tumor microenvironment is implicated in the systemic effects of disease progression, such as immune suppression and metastasis. Soluble factors (SF) produced within the tumor, including cytokines, exosomes, proteases, and microvesicles, mediate pathological signaling …
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Development of an αᵥβ₆-Binding Peptide for In Vivo Applications: Modulation of Serum Stability and Biodistribution
Targeted delivery of imaging and therapeutic agents to tumors improves detection, characterization, and treatment of many types of cancers. Peptides are capable of efficient and selective delivery of a variety of cargoes to their target cells and have been in development as targeting ligands for a …
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Biodistribution and Modes of Action of Multipotent Adult Progenitor Cell therapy in Murine Models of Transplant Rejection
… our understanding of the modes of action and biodistribution of MAPC cells in in vivo models of GvHD and HP. MAPC cells were capable of delaying aGvHD onset when delivered 7 days after peripheral blood mononuclear cell (PBMC) delivery. MAPC cells were not significantly effective when …
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An Investigation of The Effect of Hypoxic Culture on Mesenchymal Stromal Cell Immunomodulation and Biodistribution in-vivo
… stromal cell (MSC) immunomodulation and biodistribution in-vitro and in-vivo. Thus far, MSC have proved therapeutically beneficial for a number of inflammatory diseases such as acute Graft versus Host Disease (aGvHD). However, despite extensive in-vitro characterisations of MSC mechansims …
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The biodistribution of monoclonal antibodies and effector cells : pharmacokinetic modeling and its role in cancer diagnosis and therapy
Thesis (Sc. D.)--Massachusetts Institute of Technology, Dept. of Nuclear Engineering, 1996.
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Biodistribution Studies of 64Cu-DOTA-Cetuximab after Intraperitoneal and Intravenous Injection in a Malignant Ascites Mouse Model of Human Gastric Carcinoma
… in gastric cancer. We conducted a comparative biodistribution study of 64Cu-DOTAcetuximab in subcutaneous (SQ) tumor and MA mouse models. A mouse xenograft model of bilateral SQ tumors that express epidermal growth factor receptor (EGFR) was established by SQ injections of NUGC-4 and MKN-45 …
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The Development of a Novel Tumor -Specific MRI Contrast Agent Targeting the High Affinity Folate Receptor: In Vitro and in Vivo Specificity, Toxicity, and Biodistribution
… activity of the folate-dendrimer. The biodistribution of the radiolabeled 153Gd-folate-dendrimer is favorable. The agent accumulates significantly more within hFR-positive tumors (3.64% injected dose/g) than hFR-negative tumors (at or below background) following 24 hours. …
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LIVER FIBROSIS IMPAIRS HEPATOCYTE TRANSDUCTION BY AAV VECTORS
… we investigated hepatocyte transduction and biodistribution of AAV8-based vectors, commonly used in liver-directed gene therapy clinical trials, in the context of liver fibrosis. Analysis of three mouse models of induced and genetic liver fibrosis revealed that fibrotic livers are transduced …
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Novel Interactions of the Hormone Leptin Revealed by PET Imaging in Rodents and Rhesus Macaques
… on leptin receptor expression, the physiological biodistribution of the hormone remains essentially unknown. In order to characterize the distribution leptin in mammals, we have developed methodologies to radiolabel the hormone and visualize its biodistribution using positron emission tomography …
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Novel antimicrobial combinations for treatment against pathogens associated with infected diabetic foot ulcers
… agents have low permeability and restricted biodistribution, their encapsulation into efficient drug delivery carriers is crucial to increasing their bioavailability and retention time. Lipodisq® (LQ) nanoparticles consist of a circular phospholipid bilayer that is stabilized by an annulus of …
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