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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"bioconjugate"”.
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Bioconjugate Strategies for Antisense Therapeutic Delivery to Glioblastoma Stem Cells
Antisense therapeutics, including antisense oligonucleotides (AONs) and small interfering ribonucleic acids (siRNAs), are powerful tools for regulating genes, making them a promising therapy for diseases such as cancer where oncogenic genes are over-expressed. The delivery of antisense therapeutics …
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The development of a radiolabelled macromolecule as a therapeutic agent for the treatment of cancer
… towards the synthesis of a macromolecular bioconjugate that was designed to: i) co-ordinate a radioisotope through a tetra-amine macrocycle (cyclam), ii) lead to passive tumour targeting via the EPR effect and a suitably large carrier such as human serum albumin and iii) induce active …
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Elastin-like polypeptide (ELP) tags for self-assembly and high-throughput processing of functional protein materials
… Self-assembly of globular protein-polymer bioconjugates into nanostructured materials is an attractive protein immobilization strategy that allows for both high protein packing density and control over protein orientation in the material. However, challenges associated with protein-polymer …
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Targeting GRP78 in Cancer with Nucleic Acid Bioconjugates
<p>Nucleic acid bioconjugates have gained widespread use in medicinal chemistry research programs aimed at fighting human malignancies such as cancer, diabetes, genetic and infectious diseases. Their popularity stems from their ability to accelerate the drug development process by conjugating …
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Design and synthesis of dihydronaphthalene vascular disrupting agents and indolequinone-based bioreductives.
… as the attempted synthesis of a CA4-tirapazamine bioconjugate drug.
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Multifunctional Chemical Cross-linkers for Drug Carriers and Molecular Probes
Bioconjugates are an indispensable tool for molecular biology as well as an established modality for biomedical imaging and drug delivery. Broadly, bioconjugation is the use of a chemical cross-linker to covalently attach non-natural reporters, chemical handles, drug cargo, or targeting ligands to …
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Solid Phase Synthesis and Biological studies on metal conjugates of bioactive peptides for targeted delivery
… characterisation of the synthesized bioconjugates was carried out by various techniques such as NMR, RP-HPLC, MS and electrochemistry. The cellular uptake and nuclear localisation of the metallocene-NLS and -TAT bioconjugates was monitored by fluorescence microscopy in living liver …
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Towards the Synthesis of the Unusual Monosaccharides Found in the Shigella sonnei O-Antigen and Analysis of Shigella flexneri 2a Glycoconjugate Vaccine Samples
… prevent shigellosis is commercially available. Bioconjugate vaccines based on the O-antigen against various Shigella serotypes are under development. Shigella sonnei and Shigella flexneri 2a are the most prevalent serotypes in industrialised and developed countries respectively and is the …
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Identification of MRSA-specific peptides and expression of peptide containing recombinant proteins for targeted photodynamic therapy
… the in vitro cytotoxic effect of the resulting bioconjugate was determined against MRSA, E. coli and keratinocytes. Pilot data demonstrated a 66% reduction in MRSA growth following incubation and irradiation with the bioconjugate in comparison to nonirradiated control cells. The conjugated …
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The Development of a Tumour-Responsive Format for Antibody Conjugates
… focus on the constituents, format, and bioconjugate chemistry—which together influence critical factors of the ADC such as stability, pharmacokinetics, and efficacy. Significant improvements have been demonstrated by use of alternative ‘non-IgG’ ADC formats, which has facilitated greater …
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The Development of Vinylheteroarene Linkers for Proteinogenic Cysteine Modification and Studies Towards Applying (+)-Discodermolide as a Novel Payload in Antibody-Drug Conjugates
… conjugate addition reaction rate and resulting bioconjugate stability. Thus, a panel of vinylheteroarenes with differing heterocyclic groups were synthesised and evaluated for their suitability. Using small molecule model systems, vinylheteroarene linkers were assessed for cysteine reactivity …
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Controlling nanostructures of globular protein-polymer block copolymers in bulk solutions and in thin films
… of globular protein-polymer block copolymers. Bioconjugates composed of a model red fluorescent protein, mCherry, and a synthetic homopolymer with different chemical moieties are synthesized. Modulated interactions between protein and polymer by introducing polymer blocks with different …
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PREPARATION OF NANO- AND MOLECULAR COMPOUNDS FOR ANTITUMORAL APPLICATIONS TRIGGERED BY LIGHT
… two projects. One concerns the preparation of a bioconjugate between a tris-cyclometalled Ir(III) complex and a peptide nucleic acid (PNA). This work aimed to obtain a multifunctional compound with anticancer activity based on a possible synergic effect between PDT, promoted by the Ir complex, …
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A family of multi-functional phosphorescent bioprobes based on the PtPFPP scaffolding moiety
… charge, size, and substitution position of the bioconjugate. Notably, the hetero-substituted tri-PEGylated (PtcPEG31Glc, PtmPEG31Glc) and tetra-PEGylated (PtcPEG4, PtmPEG4) derivatives showed reduced cell internalization compared to the 3:1 cysteamine (PtCA31Glc) derivative and 4:1 glycosylated …
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Application of silicon photonic microring resonators to the study of surface bioconjugation and protein capture agent binding kinetics
… highlighting the competing contributions of the bioconjugate reaction rate and the dynamic interactions that control opportunities for a solution-phase biomolecule to react with a substrate-bound reagent. Some of new emerging capture agents, aptamers and single domain antibodies, are also …
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Complex bioactive fiber systems by means of electrospinning
… was demonstrated using blends containing 18 wt% bioconjugate. These meshes promoted adhesion behavior of fibroblast compared to pure PLGA meshes. In a second functionalization approach, a modular strategy was investigated. In a single step, reactive fiber meshes were fabricated and then …
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Stealth Polymer Conjugates of Biologics
<p>Biologics are potent, highly specific, and well-tolerated and have become an important class of drugs. Despite their promise, most of them have a short half-life due to rapid renal elimination and in vivo degradation. Their short in vivo half-life hence necessitates frequent injections, …
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Development and validation of quantitative methods for the analysis of clinical biomarkers of iron metabolism applying stable isotopes
… [Ru(bpy)3]2+. In aqueous solutions, a complex (bioconjugate) between the ferritin and two antibodies is formed. The use of streptavidin-coated magnetic microparticles allows to retain the analyte as well as to remove the excess of antibodies and unbound species. Subsequently, the resuspended …