Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 81 for “"bioanalytical"”.
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Microfluidic Devices for Bioanalytical Applications
Poly(dimethylsiloxane) (PDMS) based microfluidic devices have a wide range of applications in chemistry, biology, environmental science and drug delivery. PDMS devices, fabricated using soft lithography were utilized in fabrication and optimization of biotin-avidin protein bioassay. In order to …
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Bioanalytical applications of microfluidic devices
The first part of the thesis describes a new patterning technique--microfluidic contact printing--that combines several of the desirable aspects of microcontact printing and microfluidic patterning and addresses some of their important limitations through the integration of a track-etched …
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Chemistry of Zirconia and Its Bioanalytical Applications
This research studies the chemical nature of zirconia and the complex surface chemistry of zirconia in order to better comprehend its behavior under chromatographic conditions. This research shows how the physical and chemical properties of zirconia depend strongly on the thermal treatment during …
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Miniature bioanalytical assays utilizing mechanical actuation of microspheres
… labor infrastructure necessary for gold standard bioanalytical assays. In such settings, lateral flow affinity assays remain the technique of choice, due to their fast time-to-result, ease-of-use and deliverable geometry. However, these assays suffer in sensitivity, with limits of detection 10 - …
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Luminescent Quantum Dot and Protein Composite Nanoparticles for Bioanalytical Applications
The first project focused on the preparation, characterization, and application of dual emission quantum dot encoded mesoporous silica microparticles. The quantum dots were added in precisely controlled ratios and were stably encapsulated within the pores of the silica. Several experiments were …
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Application of Different Bioanalytical Workflows for Proteomics of Prostate Cancer
… application of multiple mass spectrometry-based bioanalytical platforms for phosphoproteomic characterization in cell culture and clinical specimens of prostate cancer; and on the application of optimized methods to analysis of differential protein expression to reveal molecular mechanism of drug …
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Peroxyoxalate chemiluminescence and capillary electrophoresis : new methods for bioanalytical chemistry
… to improve chemical analysis in the area of bioanalytical chemistry. More specifically this thesis is focused on the development and application of new methodologies and instrumentation involving two potentially powerful techniques: 1) Chemiluminescence-a spectroscopic technique in which the …
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Application of Advanced Bioanalytical Techniques to Studies of Oxaliplatin Chemotherapy
… overall aim of this thesis was to develop new bioanalytical methodologies for studies of oxaliplatin chemotherapy when given with OCT inhibitors (cimetidine or ergothioneine) for modulating oxaliplatin toxicities. To quantify intact oxaliplatin in human plasma, an ultraperformance liquid …
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Antifouling and Antithrombogenic Ultrathin Surface Chemistry for Bioanalytical and Biomedical Applications
… glycol trichlorosilane surface chemistry, for bioanalytical and biomedical healthcare applications. Surface modification also has the advantage of being straightforward, rapid and inexpensive.One primary objective was to engineer biosensors capable of selectively and sensitively detecting …
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Bioanalytical methods for studies of homocysteine and novel cardiovascular disease indicators
… of work is significant because it proposes new bioanalytical technologies that could enhance CVD screening and treatment.
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Synthesis and evaluation of flouro and thia lipids as bioanalytical tools
Lipid catabolism plays a significant role in the survival of M.tb inside the host. The development of analytical techniques such as gas chromatography mass spectroscopy (GCMS) and liquid chromatography mass spectroscopy (LC-MS) has become popular as metabolomics tools in the study of such catabolic …
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Development of bioanalytical approaches as model tools for the rapid detection of pesticides
Pesticides are chemicals used internationally in the agricultural sector to repel and kill pests. However, misuse or misapplication of pesticides can cause detrimental effects for humans and animals, including livestock and non-target organisms. In addition, many studies have linked pesticides with …
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The Investigation and Application of Alternative Strategies for LC/MS based Bioanalytical Research
… showed significant benefits for LC/MS/MS based bioanalytical assays when analyzed with electrospray positive ionization mode. Increases in the signal-to-noise values were observed for twenty-two out of twenty-four of the probe pharmaceuticals tested. Increase in the chromatographic retention of …
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In situ formed magnetic ionic liquids: DNA extraction performance and fluorescence-compatibility in bioanalytical applications
<p>Extracting genomic DNA from complex biological sample matrices is often the first step in numerous molecular biology procedures such as polymerase chain reaction (PCR), cloning, and gene therapy. Obtaining high yields and pure DNA presents a significant sample preparation challenge in nucleic …
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Towards Early State Disease Detection in Microdevices: Fabrication and Testing of Micro Total Analysis Systems for Bioanalytical Applications
… labeled amino acids was used to illustrate bioanalytical applications of these microdevices. Initial on-chip infrared spectroscopy results for qualitative analyte identification were achieved in microfluidic CaF2 channels. I have also shown the evaluation of poly(methylmethacrylate) (PMMA) …
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I. Bioanalytical Applications of Polymer Microfluidic Devices. II. Examination of Soft Vibrational Modes for Alkanes Adsorbed on Copper
Part II. The study of saturated hydrocarbons on metal surfaces continue to be of interest in order to understand molecule-surface interactions related to C-H bond activation. Interest has also been enhanced by the presence of a unique spectral feature, a broad vibrational mode that is shifted to …
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Bioanalytical applications of fluorescence line-narrowing and non-line-narrowing spectroscopy interfaced with capillary electrophoresis and high-performance liquid chromatography
… with CE and HPLC will be useful in many more bioanalytical applications.</p>
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The determination of β-endosulfan and endosulfan sulfate in human serum with dialkylphosphate metabolites as urinary markers using LC-MS/MS electrospray ionization
Two separate bioanalytical methods were developed, validated and applied to determine agricultural exposure to organochlorine and organophosphorus pesticides using different biological matrices as reference sources. The method that was validated for the quantification of the organochlorine …
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