Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"bioactive conformation"”.
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Design, Syntheses and Bioactivities of Androgen Receptor Targeted Taxane Analogs, Simplified Fluorescently Labeled Discodermolide Analogs, and Conformationally Constrained Discodermolide Analogs
… anticancer drug candidate. Understanding the bioactive conformation of discodermolide is important for drug development, but this task is difficult due to the linear and flexible structure of discodermolide. Indirect evidence for the orientation of discodermolide in the tubulin binding pocket …
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Synthesis and CD4 down-modulation potencies of CADA head analogs
… into host cells. Previous studies of solid-state conformations and structure-activity relationships suggest that CADA compounds bind to the target in an unsymmetrical manner. The isobutylene head group of CADA is believed to favor this unsymmetrical conformation of the 12-membered ring. We …
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Modeling of flexible drug-like molecules : qsar of GBR 12909 analog dat/sert selectivity
… like GBR 12909 have multiple possible binding conformations, distributed across the potential energy surface in key torsional angle space, which can vary from the GEM by as much as 20 kcal/mol or more. The significance of this study lies in the combining of a clustering technique for …
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Defining peptide structure with metathesis.
… of peptide structure in order to induce conformational constraint in novel macrocyclic peptidomimetic inhibitors and to develop novel hydrogel matrices, which are of importance in the advancement of the pharmaceutical and medical industries. The realization that enzymes bind their …
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Overcoming Acquired Resistance to BRAF Inhibitors by Novel Synergistic Drug Combination and Discovery of Novel Smac Mimetics as Selective Survivin Inhibitors
… IAP inhibitors. In this report, we used the bioactive conformation of AVPI tetrapeptide in the N-terminus of Smac as a template and performed a shape-based virtual screening against a drug-like compound library to identify novel IAP inhibitors. Top hits were subsequently docked to available …
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Design and synthesis and testing of conformationally constrained peptidomimetics.
… testing of peptidomimetics pre-organised into bioactive conformations. Chapter One introduces the concept of peptidomimetics, their importance as potential pharmaceuticals. The concept of constraining a compound into a bioactive conformation (α-helix, β-turn or β-strand) by incorporation of a …
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Design, Syntheses and Biological Activities of Paclitaxel Analogs
The conformation of paclitaxel in the bound state on the protein has been proposed to be the T-taxol conformation, and paclitaxel analogs constrained to the T-taxol conformation proved to be significantly more active than paclitaxel in both cytotoxicity and tubulin polymerization assays, thus …
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Importance of the Gastrin N-Terminal Region in Binding and Activation of the Putative G17-Gly Receptor on Human Colonic Carcinoma Cells
… activate the putative receptor, as well as the conformational features important to bioactivity, were examined.|The pentaglutamyl sequence-containing peptide G17(1-12) and G17(1-3)-NH2, G17(1-4)-NH2, G17(1-5)-NH2, G17(1-6)-NH2, and their non-amidated variants were made using solid phase peptide …