"binding electrostatics" · 2 results · Global ETD Search

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Showing 1 to 2 of 2 for “"binding electrostatics"”.

Computational ligand design and analysis in protein complexes using inverse methods, combinatorial search, and accurate solvation modeling

Altman, Michael DarrenMassachusetts Institute of Technology2006

… can explore the space of ligands compatible with binding to a target protein using fast combinatorial search methods. The inverse design method was applied to design inhibitors of HIV-1 protease that should be less likely to induce resistance mutations because they fit inside a consensus substrate …

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Specific Binding Affinity of the Non-Catalytic Domain of Eukaryotic Like Type IB Topoisomerase of vaccinia Virus

Reed, Benjamin RThe Graduate School and University Center of The City University of New York2017

… domain (NTD) is important for pre-cleavage binding and affinity for the target site. A combination of NMR-based interaction studies, the measurement of backbone dynamics using <sup>15</sup>N relaxation measurements, and isothermal calorimetry (ITC) is used in this work to show that the NTD …

cuny-grad Repository record for Specific Binding Affinity of the Non-Catalytic Domain of Eukaryotic Like Type IB Topoisomerase of vaccinia Virus (opens in a new tab)