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Showing 1 to 11 of 11 for “"biliverdin"”.
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Biliverdin reductase in cardiovascular inflammation
Biliverdin Reductase (BVR) functions downstream of Heme Oxygenase 1 (HO-1) in the process of heme degradation and catalyses the reduction of biliverdin to bilirubin. For over thirty years, BVR was regarded as rather a trivial enzyme whose only known function was to aid heme disposal. Over the last …
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Novel Design Strategies For Engineering Biliverdin-Binding Fluorescent Proteins
… classes of photoreceptors to covalently attach biliverdin (BV), a heme metabolite that is endogenous to mammalian tissue, as their chromophore. While these proteins have been engineered to have modest quantum yields and fluorescence in vitro, performance in mammalian cells does not correlate …
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Synergistic development of an engineered biodegradable theranostic probe and lymph node organ-on-a-chip to study nanoparticle-lymphatic interactions
… developed biodegradable nanoparticles made of biliverdin, an endogenous fluorophore that results from the breakdown of hemoglobin. We demonstrated the degradation of biliverdin nanoparticles (BVNPs) in the presence of biliverdin reductase, as well as the use of BVNPs in photoacoustic imaging of …
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Role of the Haem Oxygenase Pathway in Protection against Vascular Dysfunction
… enzyme which degrades haem to the antioxidant biliverdin and carbon monoxide (CO) releasing ferric (Fe3+) iron. Biliverdin is rapidly converted to another potent antioxidant, bilirubin, by the cytosolic enzyme biliverdin reductase. Of the three known isozymes, the inducible isoform (HO-1) has …
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Cerebral Amyloid Angiopathy and Transition Metals in Alzheimer's Disease
… of heme degradation enzymes, heme oxygenase and biliverdin reductase. Finally, because the mechanism(s) underlying vascular fragility in CAA is unknown, we evaluated the role of terminal complement on cerebrovascular elements in the setting of CAA. This may provide mechanistic clues to how the …
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Heme Oxygenase-2 as a novel target to treat inflammation and chronic neuropathic pain associated with corneal injury and surgery
… supplementation of HO by-products (CO and/or biliverdin) rescue the cornea from the aberrant inflammatory and reparative response in a model where the HO system is impaired.
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Calcium Dynamics Affecting Egg Production, Skeletal Integrity, and Egg Coloration in Ring-necked Pheasants (Phasianus colchicus)
… pigment decreased with increasing calcium. Biliverdin had a higher affinity for calcium than protoporphyrin. In Chapter 4, we examined male pheasants to determine if reduced surface area on one wing (clipped) induced unbalanced pectoralis muscle development and humerous density on the …
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Molecular mechanisms of the cytokine-dependent induction of the heme oxygenase-1 gene: in vivo and in vitro studies
… (CO), zweiwertigem Eisen (Fe2+) und Biliverdin katalysiert. Wegen der facettenreichen anti-entzündlichen Wirkweisen dieser Produkte, wurde vorgeschlagen daß HO-1 in der Akuten-Phase Reaktion, der Abwehrreaktion des Organismus gegen schädigende oder verletzende Agentien, eine Rolle …
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Modulation of heme oxygenase-1 activity by novel synthetic compounds for pharmacological applications
… carbon monoxide (CO), free iron (Fe2+), and biliverdin (BV), then reduced to bilirubin (BR). HO-1 also acts as a signaling molecule that mediates the activation of oxidant-responsive transcription factors in the nucleus. Mounting evidence underlines that HO-1 exerts antioxidant, …
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Stereoselectivity, kinetics, and engineering of flavin/deazaflavin oxidoreductases for use in industrial biocatalysis
… which donate hydrides into substrates such as biliverdin, aflatoxins, quinones and fatty acids using the reduced form of the cofactor. Several enzymes in the FDOR-A subgroup were screened for substrate range and activity, leading to the identification of two particularly promiscuous enzymes …
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Stereoselectivity, kinetics, and engineering of flavin/deazaflavin oxidoreductases for use in industrial biocatalysis
… which donate hydrides into substrates such as biliverdin, aflatoxins, quinones and fatty acids using the reduced form of the cofactor. Several enzymes in the FDOR-A subgroup were screened for substrate range and activity, leading to the identification of two particularly promiscuous enzymes …