Global ETD Search
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Showing 1 to 6 of 6 for “"bile salt export pump"”.
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Differentielle Regulation organischer Anionentransporter der Oatp-Familie bei Ethinylöstradiol-induzierter Cholestase der Ratte
… Impaired sodium-dependent uptake of bile acids has been associated with diminished expression of the basolateral Natrium/bile acid cotransporter (Ntcp), whereas sodium-independent uptake is maintained despite a down-regulation of the organic anion transporter Oatp1. Thus, expression …
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Der kanalikuläre Gallensäurentransporter der Leber als Kandidatengen für den Gallensteinlocus Lith 1
… locus Lith 1, the gene encoding the canalicular bile salt export pump of the liver Abcb11, was characterized in detail and overexpressed in vivo by generating a BAC (bacterial artificial chromosome) transgenic mouse. In a molecular biological analysis, sequence information in unknown regions of …
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Genetische Prädisposition der intrahepatischen Schwangerschaftscholestase : Mutationsanalyse des Phospholipidtransporters ABCB4 und der Gallensäurenexportpumpe ABCB11
… Mutations in the ABCB11 encoding the bile salt export pump BSEP may as well predispose for ICP. In 28 Swedish and German patients suffering from MSUD a mutational analysis was accomplished, furthermore clinical and biochemical data were obtained and correlations were calculated. There …
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Assoziationen zwischen Polymorphismen lithogener Kandidatengene und Risikofaktoren der Cholesterincholelithiasis
… LDL receptor related protein 2 (LRP2) and the bile salt export pump (ABCB11) were tested. Further candidate genes included hepatic lipase (LIPC) in the Lith5 locus and the hepatic HDL receptor (SRB1) known to be associated with serum levels of HDL cholesterol, the major source of biliary …
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Understanding the transport mechanisms of BSEP to improve the prediction of DILI compounds
… reached in 2016 on the importance of the liver bile salt export pump (BSEP) and the need to test for BSEP inhibition at an early stage of drug development. An assay for BSEP-mediated bile acid transport was established to study the biochemical mechanisms of inhibition of BSEP activity by organic …
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Role of Src phosphorylation of FXR in bile acid regulation
Bile acids are physiological detergents which aid in the absorption of dietary lipids and lipid soluble vitamins but also function as fed state signaling molecules. Elevated bile acid levels in the liver can lead to cholestatic injury, primary biliary cirrhosis, fibrosis, and liver cancer; …