Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"bile salt"”.
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Bile salt-stimulated human milk lipase characterisation and kinetic studies
… Chapter Three describes the purification of bile salt-stimulated human milk lipase (BSSL) from whole human milk. A detailed study of the activity of the purified protein has been conducted against both lipid and ester substrates in order to monitor the progress of the purification. A further …
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Characterizing induced gene expression in Shigella flexneri following bile salt exposure
… Shigella utilizes host physiology, specifically bile salts as signals for invasion and virulence gene expression. This study aimed to build upon previous research analyzing the bile salts transcriptional profile of Shigella flexneri 2457T, in which an induction of the uncharacterized gene was …
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Purification and characterization of the bile salt hydrolase (BSH) from and regulation of BSH activity in Lactobacillus sp. strain 100-100
Restriction data tranferred 2014-07-01T11:23:09-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission
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The design, syntheses, and physico-chemical studies of MRI contrast agents
… agents: the DTPA bisamide macrocycles and the bile salt-like hepatobiliary targeted contrast agents.
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Gut microbiota-mediated bile acid metabolism: implications for oral drug absorption
… investigates a potential mechanism, ‘microbial bile acid metabolism’, by which the intricate interplay between the host and gut bacteria may affect the pre-absorption behaviour and uptake of orally administered drugs. Bile salts have long been appreciated within the pharmaceutical field to be …
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Enumeration, isolation, identification and probiotic characterisation of lactic acid bacteria from Nigerian human breast milk
… a series of experiments. Initially the acid and bile resistance of the selected isolates were studied. All eleven LAB showed good tolerance to low pH and high concentration of bile salt. The antimicrobial activity of the isolates was also assessed. Again all eleven LAB produced antibacterial …
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Strain identification, viability and probiotics properties of lactobacillus Casei
… Lactobacillus strains in the presence of acid, bile salts and the or bile salt deconjugation, 3) to investigate viability of freeze dried Lactobacillus strains at various temperature during storage and their proteolytic activity, 4) to investigate the growth, viability and activity of …
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Resistance to antimicrobial agents in bifidobacteria
… with inhibitory host-produced substances such as bile salts. Another aspect which should be studied is the safety of the probiotic bacterium and risks of acquisition of genes for resistance to antimicrobial agents. Although bifidobacteria exhibit resistance to a wide range of antibiotics, little …
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Characterization of lactic acid bacteria from Nono, a Nigerian naturally fermented milk product
… properties including tolerance to acidic pH and bile salt, antimicrobial activity against indicators of food borne pathogens, and resistance to antimicrobials. The LAB were enumerated and isolated from Nono using MRS, M l7 and MRS + LCysteine agars. These media were selected to harvest a diverse …
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MECHANISMS OF RAPID RESOLUTION OF DIABETES FOLLOWING ILEAL INTERPOSITION SURGERY IN THE RAT
… expression profiles and significant changes in bile salt profiles. Interestingly, rats that received IT surgery prior to the onset of diabetes could not be improved. In addition, if a small segment of ileum is removed from the intestinal tract rats can still maintain euglycemia. Because the …
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Design and Synthesis of Cellulose Ether Derivatives for Oral Drug Delivery
… we further utilized olefin CM to conjugate bile salt derivatives (e.g. lithocholic acid and deoxycholic acid) to a cellulose backbone by converting bile salts into acrylate substrates. Successful CM of bile salt acrylates to cellulose olefin “handles” further demonstrated the great …
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Tale of Two Hosts: Vibrio parahaemolyticus Toxicity Against Human and Shrimp
Bile is an important component of the human gastrointestinal tract with an essential role in food absorption and antimicrobial activities. Enteric bacterial pathogens have developed strategies to sense bile as an environmental cue to regulate virulence genes during infection. We discovered that …
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Tale of Two Hosts: Vibrio parahaemolyticus Toxicity Against Human and Shrimp
Bile is an important component of the human gastrointestinal tract with an essential role in food absorption and antimicrobial activities. Enteric bacterial pathogens have developed strategies to sense bile as an environmental cue to regulate virulence genes during infection. We discovered that …
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Self-assembly of helical ribbons from chiral amphiphiles
… thought to be a property unique to model bile systems, is a general phenomenon of quaternary sterol systems composed of a bile salt or nonionic detergent, a phosphatidylcholine or a (mixture of) fatty acid(s), and a steroid analog of cholesterol in water. The majority of helical ribbons …
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The intestinal absorption of n-3 and n-6 polyunsaturated fatty acids: proposed mechanisms from studies using human Caco-2 cells.
… degree of solubilisation of the fatty acids in bile salt micelles (which is affected by the concentration in bile salt, the pH and the degree of saturation of the FA). It was concluded that the LCFA solubilisation of in 10 mM sodium taurocholate solutions buffered between pH 6.8 and 7.0, allows …
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THE BIOTRANSFORMATION OF BILE ACIDS BY A COMMON MEMBER OF THE BISON GUT MICROBIOME
Bacterial biotransformation of bile acids (BAs) is increasingly recognized to play an important role in the health and disease of the host. Bile acid-modifying bacteria participate in the production of a large number of secondary BAs (2 BAs) with known and yet to be discovered activities. In the …
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Regulation of to xin Synthesis By Clostridium Difficile
… levels of the common human conjugated bile salt, taurocholate, was found to inhibit toxin A and B <em>in vitro</em> activities. When co-incubated <em>ex vivo</em> with purified toxin B, taurocholate protected Caco-2 colonic epithelial cells from the damaging effects of the toxin. …
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Structural and functional studies of type three secretion virulence factors from gram-negative pathogenic bacteria
… controls the first step of TTS activation. The bile salt deoxycholate (DOC) binds to IpaD to induce recruitment of the first translocator, IpaB, into the maturing tip complex. The pore-forming translocators are bound by the class II chaperone, IpgC, within the bacterial cytoplasm in order to …
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The impact of bile and anaerobic stress on Listeria monocytogenes isolates
… barrier. In this study the effect of bile and anaerobic stress on L. monocytogenes was assessed. Bile has antimicrobial properties and it is one of the stressors that L. monocytogenes must overcome in the human gastrointestinal tract to establish infection. L. monocytogenes uses an …
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The molecular genetic investigation of paediatric liver disease
… molecular pathogenesis such as a ciliopathy or bile salt transport defect.
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