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Showing 1 to 20 of 84 for “"bile acid"”.
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Role of TGR5 in Bile Acid Metabolism
TGR5 is a G protein-coupled bile acid receptor present in various tissues in the body. Its agonism increases energy expenditure and lowers blood glucose. Thus, it is an attractive drug target for treating human metabolic disease. However, TGR5 is highly expressed in the gallbladder, where its …
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Chemical investigations into the physiology of bile acid skeletons
Bile acids are a class of surfactants that facilitate the digestion of dietary lipids and fat soluble vitamins in the intestines of vertebrates. Since they are the end products of cholesterol metabolism, bile acids biosynthesis is the major pathway to remove excess of cholesterol, which is another …
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The effects of bile acid sequestrants on the microbiome in the diagnosis and management of bile acid diarrhoea and post-operative Crohn’s disease
Bile acid diarrhoea is a poorly understood gastroenterological condition despite it affecting an estimated 1% of the general population. It can present concomitantly in other conditions such as post-cholecystectomy and Crohn’s disease, where it is found in over 90% of patients following a terminal …
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Bile acid modulation of macrophage phenotype in colorectal cancer risk
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-08-01
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Role of Src phosphorylation of FXR in bile acid regulation
Bile acids are physiological detergents which aid in the absorption of dietary lipids and lipid soluble vitamins but also function as fed state signaling molecules. Elevated bile acid levels in the liver can lead to cholestatic injury, primary biliary cirrhosis, fibrosis, and liver cancer; …
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Nuclear Hormone Receptor-Mediated Changes of Cholesterol, Triglyceride, and Bile Acid Physiology in Response to Alterations in Cholesterol Absorption and Bile Acid Pool Size in Mice
… and physiological changes that occur with bile acid pool size restoration in mice that have a bile acid deficiency. This project highlighted the importance of bile acids in cholesterol absorption, the function of the bile acid-responsive nuclear hormone receptor farnesoid X receptor, and …
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The Role of OSTalpha/beta in Bile Acid and Lipid Metabolism
Bile acids are synthesized from cholesterol in the liver. Fecal bile acid excretion accounts for nearly half of daily cholesterol disposal. It has been known for many years that ileal resection or blocking intestinal apical absorption of bile acids induces hepatic bile acid synthesis. However, …
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Study of the baiG Gene in Bile Acid 7α-Dehydroxylating Bacteria
Recently, intestinal bile acid 7α-dehydroxylating bacteria have been implicated in cholesterol gallstone disease. Eubacterium sp. strain V.P.I. 12708, a bile acid 7α-dehydroxylating bacteria, contains multiple bile acid inducible (bai) genes which are located on a large bai operon. Genes of this …
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Study of the baiE Gene in Bile Acid 7α-Dehydroxylating Bacteria
Intestinal bile acid 7α-dehydroxylating bacteria have recently been implicated in cholesterol allstone disease. Eubacterium sp. V.P.I. 12708, a bile acid 7α-dehydroxylating bacterium, contains multiple bile acid inducible (bai) genes which encode the enzymes responsible for bile acid …
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Gut microbiota-mediated bile acid metabolism: implications for oral drug absorption
… investigates a potential mechanism, ‘microbial bile acid metabolism’, by which the intricate interplay between the host and gut bacteria may affect the pre-absorption behaviour and uptake of orally administered drugs. Bile salts have long been appreciated within the pharmaceutical field to be …
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Regulation of Bile Acid Biosynthesis by Orphan Nuclear Receptor Small Heterodimer Partner
… should greatly advance our understanding of how bile acid biosynthesis is regulated in both SHP-dependent and SHP-independent pathways. Importantly, these studies for the first time demonstrate that SHP has a short half-life of 20 to 30 minutes. Bile acids and FGF15/19 signaling pathways, and SHP …
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Bile acid nuclear dehydrogenation by Clostridium species and its implication in colorectal carcinogenesis
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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The Role of OSTα-OSTβ and Bile Acid Transport in Intestinal Disorders Aand Metabolic Disease
Over the past 60 years, the study of bile acids has evolved from an esoteric source of fascination for chemists to becoming a field of enormous potential and discovery. Among their important physiological properties, bile acids function as critical detergents to solubilize biliary and dietary …
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Characterization of enzymatic pathways involved in cortisol and bile acid metabolism by the gut microbiota
… alter the physicochemical properties of bile acids with implications for increased/decreased toxicity for gut bacteria and the host. We located a gene-cluster in Eggerthella CAG:298 predicted to encode three HSDHs (CDD59473, CDD59474, CDD59475), synthesized the genes for heterologous …
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The Metabolic Impact of the Gut-Liver Bile Acid Signaling in Metabolic and Inflammatory Liver Disease
Bile acids are synthesized from cholesterol in hepatocytes and secreted into bile. After a meal, bile acids are released from the gallbladder into the small intestine to facilitate the digestion and absorption of dietary fats and lipid soluble vitamins. Most bile acids in the intestine are …
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The Effects of Carbadox, a Synthetic Antimicrobial Agent, on Bile Acid Metabolism in The Domestic Pig
In order to study the bile acids of the young pig as they go through enterohepatic circulation without altering bile flow from the gall bladder, a surgical technique was developed to place indwelling catheters into the hepatic portal vein (HP) which allowed multiple sampling of the blood and did …
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The roles of orphan nuclear receptors, SHP and FXR, and their cofactors in bile acid signaling
Bile acids, the end-product of cholesterol catabolism, are important for absorption and solubilization of lipids in the intestine because of their detergent properties. In addition to their roles as detergents, previous studies have revealed that bile acids function as signaling molecules in …
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