Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"bifunctional ligands"”.
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Novel Bifunctional Ligands For Neuropathic Pain: Design and Synthesis of Overlapping Pharmacophores of Opioid and Melanocortin Ligands
… as a therapeutic target. MC4R based agonist ligands produce anti-opioid effects, and researchers have shown that an antagonist of the MC4R can produce pronounced anti-allodynic effect. Opioid receptors have been the central and most efficacious targets sought after for relieving neuropathic …
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DESIGN, SYNTHESIS AND PHARMACOLOGICAL INVESTIGATION OF NOVEL BIFUNCTIONAL COMPOUNDS
… Aims - The deliberate, rational design of bifunctional (multiple) ligands has gained a relevant interest in the medicinal chemistry research. These compounds may serve as suitable molecular probes to study in depth receptor architectures and, in some instances, represent innovative …
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Engineering of Alkali Metalorganic Precursors: Synthesis to Mechanistic Aspects
… a unique class of complex where the monovalent bifunctional ligands' strong chelating ability leads to the synthesis of several neutral complexes with predominant covalent characteristics, such as solubility in organic solvents and volatility, thereby often referred to as adding 'wings' to the …
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Sintesi e valutazione preclinica di ligandi per i recettori sigma utili per il trattamento dei tumori e per la gestione del dolore
Gli obiettivi di questa tesi di dottorato sono stati perseguiti con lo scopo di identificare nuove molecole di sintesi con efficacia terapeutica. Il lavoro è stato condotto presso il Dipartimento di Scienze del Farmaco e della Salute (Università degli Studi di Catania) e presso il Dipartimento di …