Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"biased signaling"”.
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Fusion Proteins as Selective Inducers of Constitutive Activity and Tools to Discriminate the Biased Signaling Profile of β2 Adrenoceptor Ligands
… responses by the stimulation of specific signaling pathways. The best-established signaling pathways for the β2AR are the canonical Gs pathway and the alternative β arrestin 2 (βarr2) pathway. Exploring each pathway separately remains a challenging task due to the dynamic nature of the …
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Caffeine Binding Non-Canonical Biased Adenosine A₂AR GPCR Modulates Neu1 Activation and Signaling in Breast Cancer Cells
Dysregulated receptor signaling networks contribute to breast cancer progression and metastatic plasticity, particularly in triple-negative breast cancer (TNBC), an aggressive subtype with limited therapeutic options. Among these signaling systems, the adenosine A₂A receptor (A₂AR), a G …
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Alternative rownstream roles for Ste2p and an α-arrestin in sacccharomyces cerevisiae mating
… Receptors (GPCR) those are involved in the signaling of mating responses that lead to cell fusion. Their signaling–associated interactions with G-protein/MAPK signal transduction machinery are well established, homologous to those in mammalian systems, and serve as a simplified model system …
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Acidosis Activated GPR68 Promotes Vascular Smooth Muscle Cell Growth
… and is thought to signal through stimulatory Gs signaling. The Gs pathway is known to activate cyclic AMP and its downstream effectors PKA and EPAC, yet the influence of GPR68 and its cyclic AMP signals on VSM cell (VSMC) growth in the context of CVD in not known. The hypothesis of this study was …
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Cannabinoid Type 2 Receptors Promote Cadherin Switching While Suppressing Cell Migration: A Novel Investigation into Biased GPCR Signaling
… (GPCR) CB2 may result from pathway-selective signaling, contingent upon the diverse cancer-related signaling modulated by cannabinoid receptors. Nonetheless, the precise mechanism(s) by which CB2 regulates gene expression involved in cancer development and progression remain largely …
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Functionally selective receptor signaling and endocytosis by dopamine D1 receptor agonists
… selective agonists, which activate one D1R signaling pathway over another have been recently described. Functionally selective agonists, also known as biased agonists, may fine-tune receptor signaling to improve therapeutic efficacy and/or reduce adverse effects. However, the …
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FUNCTIONAL SELECTIVITY DOWNSTREAM OF Gαi/o-COUPLED RECEPTORS
… are drug targets that often activate multiple signaling pathways. The multiple GPCR responses provide opportunities for biased or functionally selective ligands to preferentially modulate one signaling pathway over another. Studies with several GPCRs have suggested that selective activation of …