Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"bi-phasic"”.
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Effect of lauric acid and monolaurin on the multiplication of Listeria monocytogenes and Listeria innocua at 10°C in bi-phasic systems.
… mM) and lauric acid (5.0 mM) alone and in combination has been tested on growth of three cheesebome strains of Listeria monocytogenes and two strains of L. innocna. The Listeria spp. were grown in Tryptose Soya Yeast Glucose Broth (TSGYB) in shake culture at 10 °C and an initial pH of 7.0. …
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Structure-property relationships in poly-(propylene-ethylene) copolymers
… properties of poly-(propylene-ethylene) bi-phasic copolymers. The copolymers investigated covered a comonomer content ranging between 4 and 23 percent ethylene. Nine grades were considered, with variables such as the melt flow index, the degree of crystallinity, the molecular weight …
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The Role of Mechanics on Microbial Ecology within Confined Spaces
… driven by mechanical interactions when microbial colonies inhabit a confined and packed environment, which is crucial to the stability and diversity of the entire ecological system. However, much of the dynamics is lost in conventional bulk measurements without access to single-cell …
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A Multi-Method Examination of the Perfectionism Social Disconnection Model Among Adolescents: Testing the Unique Role of Online (Dis)Connection
The purpose of the current bi-phasic, multi-method study was to provide a comprehensive and rigorous test of the Perfectionism Social Disconnection Model (PSDM) among adolescents, with a focus on the role of online connection. According to the PSDM, perfectionism is thought to be linked with a lack …
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The Role of A2B Adenosine Receptor Signaling In Adenosine Dependent Lung Disease
… disorders that result in significant morbidity and mortality. Adenosine is a signaling nucleoside generated in response to injury and can serve both protective and destructive functions in tissues and cells through interaction with four G-protein coupled adenosine receptors: A1R, A2AR, …
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Real-time Three-Dimensional DNA Microarrays: How Well Can We Distinguish Between Related Target Sequences?
… rapid identification of known or related microbial species, but our ability to extract meaningful information from microarray images is still at a rudimentary level. The use of DNA microarrays is currently hampered by a few key analytical and theoretical challenges. In particular, the nucleic …
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A Role for BDNF-Trkb Signaling in the Modulation of Superoxide Dismutase-1 Expression
… using TrkB mutants and pharmacological inhibitors of pathways known to be associated with TrkB revealed that the kinase activity of the receptor is necessary and that partial TrkB signaling is sufficient for suppression. Conversely, treatment with brain-derived neurotrophic factor (BDNF), an …
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Growth, modelling and remodelling of cardiac tissue: a multiphase approach
… remodelling of the microstructure, a continuum bi-phasic model applicable to cardiac tissue is formulated based on the theory of porous media (TPM). This makes it possible to account for interactions and contributions of multiple phases of constituent materials, which in computational cardiac …
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D-METHIONINE (D-MET) MECHANISMS UNDERLYING OTOPROTECTION FROM NOISE- AND AMINOGLYCOSIDE-INDUCED HEARING LOSS
… optimal, sub-optimal, and supra-optimal bi-phasic D-met otoprotective dose response. Optimal D-met protection from steady state noise occurred at the 50 mg/kg/dose level. OHC quantification confirmed electrophysiological assessment. Specific aim 2 measured D-met rescue protection from …
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Cytoskeletal Remodeling in Fibrous Environments to Study Pathophysiology
… their behavior in response to specific ECM biophysical cues including fiber size, spacing, alignment and stiffness remains in infancy. Here, we utilize the non -electrospinning Spinneret tunable engineered parameters (STEP) technique to manufacture ECM mimicking suspended fibrous matrices …
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Characterisation and therapeutic modulation of toll-like receptor signalling in response to the intracellular pathogen F. tularensis
… of these signalling proteins was found to be bi-phasic with an early transient activation of both ERK and p38 followed by a sustained activation of ERK and a suppression of p38 activation at later time points. The role of ERK was investigated further using a specific inhibitor (PD0325901). …
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The effects of eccentric exercise on delayed onset muscle soreness, muscle function and free radical production
… downhill running. The study demonstrated a bi-phasic increase in creatine kinase (CK), with the second increase corresponding with the post-exercise ROS production. The study extended the postexercise sampling period to 96 h, however, ROS were still increasing at this time and therefore this …
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Cardiovascular effects of lead and mercury and their mixtures in rats
… on the cardiovascular system. Lead showed bi-phasic dose-response curves for several cardiovascular end-points. No cardiovascular effects were observed for inorganic mercury, while methylmercury showed linear dose-response curves. Based on these results, safe levels of exposure for lead and …
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Engineered Replicases, Synthetic DNA, and Long-Read Sequencing Quality Control for Adeno-Associated Virus Production
… diseases can be treated with modified (recombinant) viruses that deliver therapeutic transgenes. Recombinant adeno-associated viruses (rAAV) are the most promising candidates for treatment, as clinical trials have demonstrated the safety of the vector at low and medium-dose, and three …
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The Effect Of An Intermittent Manganese (ii) Exposure On The Striatal Dopamine System
… in the basal ganglia. Understanding the neurobiological consequences of overexposure to Mn is critical to develop better treatment strategies. The principle objective of this research is to study the impact of Mn exposure on the striatal dopamine. The first objective was to develop a sensitive …
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Fate and behaviour of metformin and its transformation product guanylurea in soil-water systems
… studies of MET and GUA indicated that combined hydrolysis and photolysis contributed to <30% degradation at neutral pH. Hydrolysis of MET was <16% for all pH range studied while hydrolysis of GUA resulted to 60% and 50% degradation in acidic (pH4) and basic (pH 9) solutions, respectively. …
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Hypoxia-mediated human pulmonary arterial fibroblast proliferation is dependent on p38 mitogen-activated protein kinase activity.
… p38 MAPK activity appeared to occur in a bi-phasic pattern with peaks of activity at t = 6 and 16 hours, the second peak was found to be responsible for the hypoxia-mediated proliferation seen in these cells in agreement with previous work from the SPVU laboratory (Scott et al, 1998; Welsh …
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Immobilisation of Bio-molecules on Magnetisable Solid Supports for Applications in Bio-catalysts and Bio-sensors
… conjugation with two different classes of bio-molecules; (i) enzymes and (ii) single stranded DNA primers. The resultant nanoparticles (nano-bio conjugates) were used for applications in (i) enzyme catalysis and (ii) bio-separation / bio-sensing. Magnetite and amorphous silica-coated …
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INVESTIGATIONS INTO THE STEREOCHEMICAL AND GLUTAMATERGIC MECHANISMS OF THE "BATH SALTS" SYNTHETIC CATHINONES MEPHEDRONE AND MDPV IN RATS
… to drug seeking. We first evaluated MEPH’s ability to produce behavioral sensitization (detailed in Chapter 2), a hallmark behavior of psychostimulants involving repeated, intermittent drug administration, followed by a period of drug abstinence, and a subsequent drug challenge. This …