Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"betaherpesvirus"”.
-
Systematic Enhancement of Human Herpesvirus 6A Reconstitution: Bridging Technical Refinement and Host Determinants of Virus Replication
Human herpesvirus 6A (HHV-6A) is a betaherpesvirus that presents substantial challenges for research due to its strong propensity for latency and slow replication. This thesis addresses the critical bottleneck of efficient recombinant HHV-6A reconstitution from bacterial artificial chromosome (BAC) …
-
Investigating and exploiting the latency-associated expression of the human cytomegalovirus gene US28 in early myeloid lineage cells.
Human cytomegalovirus (HCMV) is a betaherpesvirus which establishes a lifelong persistent infection, underpinned by its ability to establish latent infection in early myeloid lineage cells, in the infected host. Although well controlled by a healthy immune system, HCMV causes pathological and life …
-
The CD4⁺ T Cell Response to Human Cytomegalovirus
Human cytomegalovirus (HCMV) is a betaherpesvirus that infects most humans worldwide. In the healthy host, it elicits a broad immune response involving both the innate and adaptive arms of immunity, which is able to limit viral replication and prevent end-organ disease. However, like all …
-
Characterisation of T cell responses to proteins expressed during Human Cytomegalovirus latency
Human cytomegalovirus (HCMV) is a betaherpesvirus that establishes a lifelong infection in hosts. In the majority of cases, the immune response to primary HCMV infection limits viral replication and dissemination, such that overt clinical disease is prevented. However, the immune system cannot …