Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"beta-cell proliferation"”.
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Novel Roles of Gastrin and Cholecystokinin in Islet Beta Cell Proliferation
… 2 diabetes share a common theme: an insufficient beta cell mass to maintain glucose homeostasis. In Type 1 diabetes this deficiency arises from autoimmune destruction of the beta cells. In the latter stages of Type 2 diabetes, there is a precipitous drop in beta cell mass, resulting from the …
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Mechanism of genistein in the regulation of pancreatic beta-cell proliferation
… derived primarily from legumes, on pancreatic β-cell proliferation and the related molecular mechanisms. Diabetes mellitus is a major and growing public health problem worldwide. Both in type 1 (T1D) and type 2 diabetes (T2D), the deterioration of glycemic control over time is primarily caused by …
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TMEM27: A Cleaved and Shed Plasma Membrane Protein That Stimulates Pancreatic Beta Cell Proliferation
… the replication of terminally differentiated β cells are unclear. In this thesis I report the identification of a gene encoding transmembrane protein 27 (TMEM27) in pancreatic β cells. Expression of Tmem27 is reduced in Tcf1-/- mice, which exhibit defects in proliferation, and is increased in …
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New Roles of the Transcription Factor NKX6.1 in Beta Cell Biology
Pancreatic islet beta cells play a critical role in the maintenance of metabolic fuel homeostasis. Type 1 diabetes results from autoimmune destruction of the beta cells, whereas type 2 diabetes involves loss of beta cell function, particularly glucose-stimulated insulin secretion (GSIS), and a …
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The Effects of Chronic Stress and Exercise on Mouse Pancreatic Islet of Langerhans Morphology and Muscle Atrophy Gene Expression
… insulin sensitivity and the insulin producing beta cells of the pancreas. Exercise could serve as a possible countermeasure to the damaging effects of chronic stress due to its proven ability to increase insulin sensitivity at the level of the muscle and improve or maintain beta cell function …
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The Roles of Rap1 in Cancer Metastasis and Pancreatic Islet Beta Cell Function
… understood. Rap1 signals to pathways involved in cell adhesion, migration, and survival, suggesting that Rap1 may promote several processes associated with metastasis. Recent studies in another biological system have demonstrated that the Rap activator proteins, Epac, are important regulators of …
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Kontrollierte Expansion von Insulin produzierenden Beta-Zellen des endokrinen Pankreas durch das Protein p8
… assoziiert ist. Wir konnten p8 auch in beta-Zellen des endokrinen Pankreas nachweisen. Um Informationen über die subzelluläre Lokalisation zu erhalten, wurde ein Plasmid, das für ein Fusionsprotein aus p8 und GFP (grün fluoreszierendes Protein) kodiert, kloniert und in verschiedene …