Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"beta signaling"”.
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TGF-beta signaling at the cellular junctions
… I have studied transforming growth factor-beta (TGF-beta) signal from the secreting to the receiving cells in the developing wing epithelial cells and at the neuromuscular junctions. Cell culture studies have suggested that cells modulate morphogenetic signaling by expressing the receptors …
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Amyloid-beta signaling in physiology and pathology: from astrocytes to SUMO
… primary molecular culprit in AD is the amyloid-beta (Abeta) peptide, aggregates of which are the main components of the plaques. Numerous studies have implicated soluble Abeta oligomers as the predominant neurotoxic species, although the underlying mechanisms that lead to cognitive failure are …
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The Role of Transforming Growth Factor Beta Signaling in Inflammation-Dependent Colon Cancer
Chronic inflammatory conditions such as Crohn's disease (CD) and Ulcerative colitis (UC) are risk factors for colon cancer. TGFβ has been shown to be dysregulated in colon cancer. Bacteria-induced inflammation is necessary for the induction of colon cancer in TGFβ mouse models. However, the …
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Smad Proteins and theTgf-Beta Signaling Pathway During In Vitro Progression of Hpv16-Immortalized Human Keratinocytes' and 'Microarray Gene Expression Profiling of Exfoliated Cervical Cells'
<p>Disruption of the transforming growth factor-beta (TGF-β) signaling pathway is observed in many cancers, including cervical cancer, resulting in TGF-β resistance. While normal human keratinocytes (HKc) and human papillomavirus type 16 immortalized HKc (HKc/HPV16) are sensitive to the growth …
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TGF-β Signaltransduktion in der experimentell induzierten Leberfibrose durch die Gallengangsligatur bei der Ratte
Background/Aims: Profibrogenic TGF-beta signaling in hepatic stellate cells is modulated during transdifferentiation. Strategies to abrogate TGF-beta effects provide promising antifibrotic results, however, in vivo data regarding Smad activation during fibrogenesis are scarce. Methods: Here, liver …
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Requirement of Baboon/dsmad2-Mediated Tgf-Beta/activin Signaling for Post-Mitotic Neuronal Development in the Drosophila Brain
… of widespread Baboon/dSmad2-mediated TGF-beta/Activin signaling in various neuronal developmental processes prior to the prepupal ecdysone peak. Interestingly, this stage-specific Babo/dSmad2 signaling appears to accelerate maturation and morphogenesis of post-mitotic neurons throughout …
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TGF-beta,Smad signaling in hepatic stellate cells and during liver fibrogenesis
Transforming growth factor (TGF)-beta is a key mediator of hepatic stellate cell (HSC) activation and extracellular matrix accumulation leading to fibrosis. Aim of the present study was to perturb the TGF-beta pathway in this process by overexpression of Smad7, an intracellular antagonist of …
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Role of the Type III TGF-beta Receptor Cytoplasmic Domain in Breast Cancer Progression
… among women. The transforming growth factor-beta (TGF-β) pathway is an important modulator of breast cancer progression, acting in a tumor suppressing fashion in early carcinogenesis but switching in a poorly understood fashion to a promoter of cancer progression in later stages. …
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AN INVESTIGATION OF POTENTIAL MECHANISMS UNDERLYING CHEMOSUPPRESSIVE EFFECTS OF DIETARY FLAXSEED IN THE LAYING HEN MODEL OF OVARIAN CANCER
… chemosuppressive effects by modulating NRF2 signaling in ovarian cancer. To further investigate pathways potentially regulated by flaxseed, we performed a microarray with 44k features and found that a set of genes involved in branching morphogenesis was upregulated in ovarian cancer and …
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The Role of Extracellular Matrix Rigidity and Altered microRNA Expression In TGF-beta-Mediated Breast Cancer Progression
… poorly defined. Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that functions to suppress tumorigenesis in mammary epithelial cells (MECs). Interestingly, mammary tumorigenesis converts TGF-beta from a tumor suppressor to a tumor promoter through molecular …
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Morphological characterization of liver fibrogenesis in animal models with genetically modulated TGF-beta signal transduction
… to release cytokines, growth factors, like TGF-beta activating hepatic stellate cells (HSCs) to produce collagen, glycoproteins (such as fibronectin) and proteoglycans. Activatied HSCs differentiate into myofibroblasts expressing alpha-smooth muscle actin (alpha SMA) which are deposited in the …
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New Methods for Characterizing the Complex Neural Circuitry of the Adult Drosophila Brain
… dorsal cluster (DC) neurons suggests that TGF-beta signaling is widely required for maturation and morphogenesis of post-mitotic adult-specific neurons. Third, combined application of MARCM with a newly developed technique, called ""Flip-out"" MARCM, reveals that the Drosophila Down syndrome …
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Mesothelial and Mural Cell Contribution to Vascular Development through PDGF Signaling
… defined. The platelet derived growth factor beta (PDGFR beta) is essential for mural cell recruitment and expansion. Deletion of PDGFR beta leads to perinatal lethality resulting from vascular defects attributed to severe decreases in mural cells. PDGFR beta is a receptor tyrosine kinase with …
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Analisi dei profili di espressione dei microRNA: identificazione di biomarker nel suicidio
… that could be related to suicide, such as TGF-beta signaling pathway and long-term potentiation pathway. In conclusion, our study suggests that miR-4286 and miR-186-5p could constitute potential biomarkers of suicide and be involved in the mechanism of action of lithium.
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Runx1 in Primitive Hematopoiesis and Characterization of Hematopoietic Stem Cells in a Mouse Chronic Inflammatory Arthritis Model
… of primitive hematopoiesis by Runx1 and TGF-beta signaling.<underline> Primitive hematopoiesis, occurring exclusively in the yolk sac, is characterized by its transient nature. As the primitive hematopoiesis declines in the yolk sac, definitive hematopoietic progenitors generated in the yolk …
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Functional miRNA regulation of metastatic genes promotes tumor cell dissemination in non-small cell and small cell lung carcinomas
… pathways such as the Transforming Growth Factor [beta] (TGF[beta]) signaling network are frequently dysregulated during metastatic progression due to the similarities between early embryogenesis and tumor progression. Furthermore, the TGF[beta] pathway highlights how cell-intrinsic and extrinsic …
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Modeling colorectal cancer initiation using human iPSC-derived intestinal organoids
… pathways, including EGFR-STAT2, interferon alpha/beta signaling activation, and anti-apoptotic signaling upon EGFR induction; KRAS-CDX2 regulation and epithelial homeostasis dysregulation upon KRAS induction; and CTNNB1 to KRAS regulation upon CTNNB1 induction. Some of these pathways have been …
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Analysis of gene expression alterations in premalignant progression from normal mammary epithelium to ductal carcinoma in situ by multiple orthogonal tools
… dysregulation of various pathways such as IGF-1 signaling, integrin signaling and fatty acid biosynthesis. To further enrich the expression data and identify low abundance transcripts we employed next generation sequencing (RNA-Seq) using Illumina Genome Analyzer GAIIx. Analysis of the sequencing …
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The function of TAK1 in hepatocarcinogenesis
The MAP3-kinase TGF-beta-activated kinase 1 (TAK1) is activated in response to cytokines like TNF-alpha, TGF-beta as well as by the bacterial endotoxin lipopolysaccharide (LPS). TAK1 is involved in controlling the activation of p38MAPK, JNK, and NF-kappaB in various cellular systems thereby …
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Targeting Organic Anion Transporting Polypeptide 1A4 (Oatp1a4) for Effective Drug Delivery at the Blood-Brain Barrier
… selective regulation by targeting intracellular signaling pathways has been extensively explored; however, these approaches have been largely unsuccessful due to toxicity concerns and unpredictable pharmacokinetics. Therefore, our laboratory has proposed that optimization of CNS drug delivery, …
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