Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"beta lactam antibiotics"”.
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Stereospecific total synthesis of beta-lactam antibiotics from peptide precursors.
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 1978
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Myceloid cell formation in Arthrobacter globiformis during osmotic stress
… The myceloids were 12-20 times more sensitive to beta-lactam antibiotics than the normal bacteria and 320 times more resistant to streptomycin. Myceloids were more sensitive to heat than the coccal forms and more resistant to long term starvation in a buffer lacking a nitrogen source. These …
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Antimicrobial Resistance Mediated By Synthesis of Richmond and Sykes Type I Beta-Lactamase
A number of beta-lactam antibiotics that are relatively resistant to hydrolysis by beta-lactamases have been developed. These new compounds have expanded antibacterial activity but also have posed several challenging clinical problems including therapeutic failures and relapses of infections. …
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Mechanisms of Regulation and Resistance for Plasmid-Encoded ampC Beta-Lactamase Genes
BETA-lactam antibiotics are the largest class of antimicrobial drugs and the most frequently prescribed world wide. As the use of these agents increased so did the evolution of bacterial BETA-lactam resistance. BETA-lactamases are collectively the most commonly identified BETA-lactam resistance …
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Protein and Ligand Dynamics in Drug Development and Resistance
… have investigated a mechanism of resistance to beta-lactam antibiotics in Neisseria gonorrhoeae, which relies on modulation of conformational dynamics. Neisseria gonorrhoeae is a major growing health concern due to the rapid spread of multi-drug resistance. We have discovered conformational …
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Exploring and enhancing context-dependent beta-lactam antibiotic efficacy
Antibiotics, such as beta-lactams, are essential medical tools for the treatment of bacterial infections. Unfortunately, clinical treatment efficacy is declining over time as bacteria adapt to and evade antibiotic treatment through mechanisms called antibiotic resistance, tolerance, and …
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Molecular methods for the detection of TEM- and SHV-related beta lactamase genes in members of the Enterobacteriaceae
Bacterial resistance to antibiotics is a common and important clinical problem. Beta lactam resistance in Gram negative bacilli is mediated predominantly by beta lactamases, enzymes able to hydrolyse the beta lactam ring. The commonest plasmid mediated beta lactamases in the Enterobacteriaceae are …
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A study on the detection of extended spectrum beta lactamase producers and class I intergrons in e. coli isolates from urinary tract infected patients at UTH.
Escherichia coli that produce extended spectrum beta lactamase (ESBL) enzymes pose a global challenge in the management of urinary tract infections (UTIs) caused by these organisms. Beta lactamases are the primary cause of resistance to beta lactam antibiotics. These enzymes confer multi drug …
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A study on the detection of extended spectrum beta lactamase producers and class I intergrons in e. coli isolates from urinary tract infected patients at UTH.
Escherichia coli that produce extended spectrum beta lactamase (ESBL) enzymes pose a global challenge in the management of urinary tract infections (UTIs) caused by these organisms. Beta lactamases are the primary cause of resistance to beta lactam antibiotics. These enzymes confer multi drug …
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Cycloadditions to 1-azetines and 1-azetin-4-ones
… bi-cyclic systems of related structure to the beta-lactam nucleus of beta-lactam antibitics.Thus, three 1-azetine systems (2-4) were prepared by alkylation of their precursor azetidinones and thioazetidinones.The ability of these systems to enter into cycloaddition reactions with a variety of …
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Statistical studies of patents literature
… patenting in the field of an important group of beta-lactam antibiotics, the. Cephalosporins. Patents data was retrieved from the World Patents Index online files of Derwent Publications Limited, and the bibliographic details of each patent application retrieved analysed according to numbers of …
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Fate and effect of amoxicillin in space and terrestrial water reclamation systems
… overall effects of pharmaceuticals, specifically antibiotics, in recycled wastewater are unknown. One concern is the development of antibiotic resistance by pathogenic bacteria. Additionally, the effects of antibiotics on biological wastewater recycling systems have not been quantified. The …
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Impact of Wastewater Effluent on Surface Water Resistomes in a Small Lower-Income Community with Deteriorated Sewage Infrastructure
… in 2021. Due to inputs of antimicrobials and antibiotics excreted and flushed down the drain, nutrient rich conditions, and high active microbial density, wastewater treatment plants (WWTPs) are hypothetical hotspots for the evolution and dissemination of AMR, but also function as a crucial …
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Applications of Wastewater-Based Surveillance Within Rural and Unsewered Communities
… gene encoding resistance to clinically-important beta lactam antibiotics and the latter acts as an indicator of multi-antibiotic resistance and propensity to mobilize to new bacterial hosts. However, the general similarity may suggest that centralized sewer collection may sufficiently capture …
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DARK-PIGMENTED, AMOXICILLIN-RESISTANT, BACTERIAL SPECIES IN CHRONIC PERIODONTITIS MICROBIOTA IDENTIFIED WITH MATRIX ASSISTED LASER DESORPTION/IONIZATION TIME-OF-FLIGHT MASS SPECTROMETRY.
… Due to their frequent expression of beta-lactamase enzymes, which hydrolyze and degrade beta-lactam class antibiotics, these species may compromise systemic periodontal antimicrobial chemotherapy involving amoxicillin, which may lead to clinical therapeutic failures in chronic …
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Cargo delivery into gram-negative bacteria via enterobactin uptake machinery
… Chapters. Chapter 3. Enterobactin-Mediated P-Lactam Delivery into Gram-negative Bacteria The design, synthesis, and characterization of two enterobactin-antibiotic conjugates, where the [beta]-lactam antibiotics ampicillin (Amp) and amoxicillin (Amx) are linked to a monofunctionalized …
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Chemical and biological evaluation of antibiotic-based ionic liquids and GUMBOS against pathogenic bacteria
… GUMBOS created from an antiseptic and several â-lactam antibiotics. Using anion metathesis, four â-lactam antibiotic-based chlorhexidine GUMBOS were synthesized prior to validation using proton and carbon NMR, mass spectrometry, elemental analysis, and absorbance spectroscopy. Several orders of …
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PREDICTION OF HUMAN SYSTEMIC, BIOLOGICALLY RELEVANT PHARMACOKINETIC (PK) PROPERTIES BASED ON QUANTITATIVE STRUCTURE PHARMACOKINETIC RELATIONSHIPS (QSPKR) AND INTERSPECIES PHARMACOKINETIC ALLOMETRIC SCALING (PK-AS)
… β-adrenergic receptor ligands (β-ARL) and β-lactam antibiotics (β-LAs) using pertinent human and animal systemic PK properties (fu,, CLtot, Vdss, fe) and their biologically relevant unbound counterparts from the published literature, followed by an assessment of the effect of different …
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