Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 105 for “"beta cells"”.
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Microfluidic Assessment of Stem Cell-Derived Pancreatic Beta Cells
… traditional methods of perifusional analysis of cells, pancreatic β cells in particular, involve the utilization of costly equipment exhibiting difficulties in setup and inflexibilities in operation and application. Microfluidic devices in general are inexpensive, easy to fabricate and are …
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Molecular Dissection of Interferon-Gamma Treated Pancreatic Beta-Cells
… has a direct pathogenic role on the pancreatic $\beta$-cell. Early expression of IFN-$\alpha$ by the $\beta$-cell may contribute to insulitis whereas IFN-$\gamma,$ a product of islet infiltrating leukocytes, may mediate characteristic decreases in glucose sensitivity and increased cell surface …
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Regulation of Insulin and CHOP Gene Expression in Pancreatic Beta Cells
… gene expression is regulated in pancreatic beta cells. In addition to examining histone modifications on the insulin gene promoter, I focused on the effect of MafA modification on insulin expression. MafA is a transcriptional activator of the insulin gene via binding to the RIPE3b/C1 (rat …
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Electrophysiological characterization of insulin secreting beta-cells in pancreatic tissue slices
In der vorliegenden Studie wurde eine Präparation pankreatischer Gewebeschnitte etabliert, um unter Bedingungen nahe in vivo, die Charakterisierung Insulin sezernierender β-Zellen, zu ermöglichen. Das Arbeitsverfahren zur Herstellung von Gewebeschnitten des Pankreas ist schnell und leicht …
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Pyruvate Cycling Pathways and Glucose-Stimulated Insulin Secretion in Pancreatic Beta Cells
Pancreatic β-cells secrete insulin in response to glucose. Intracellular glucose metabolism drives a cascade of events, including ATP production, calcium influx, and insulin processing, culminating in insulin granule exocytosis. However, insulin secretory mechanisms are incompletely understood. …
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Development of orthogonally crosslinked thiol-ene hydrogels for encapsulation of pancreatic beta-cells
… destruction of insulin-producing β-cells. Effective encapsulation strategies can protect the transplanted islets from direct attack by host immune cells while maintaining insulin secretion. To achieve this goal, I have developed a hydrogel conformal coating using a visible …
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Dysfunction of Pancreatic INS-1 Beta-Cells Induced by Chronic Exposure to High Glucose
"배경 및 목적 : 제2형 당뇨병은 전 세계적으로 가장 흔하고 심각한 대사 질환이다. 정상인의 췌장베타세포는 혈중 포도당 농도 조절에 중요한 인슐린을 합성 및 분비하는 중요한 역할을 수행하고 있다. 현재 베타세포의 기능이상은 인슐린 저항성과 함께 제2형 당뇨병을 유발시키는 중요한 병인으로 인식되고 있다. 포도당은 베타세포의 기능을 조절하는 가장 중요한 조절자로서 특히 베타세포의 인슐린 유전자 발현과 생합성, 분비에 중요한 역할을 하고 있다. 그러나 포도당이 고농도로 오랫동안 베타세포에 노출될 때, 베타세포의 기능이상을 초래하며, …
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Insulin based analogs HLVEALYLV and LVEALYLV to inhibit the formation of amyloid fibrils in beta cells
… in the islets of Langerhans of pancreatic beta cells. Aggregation of hIAPP fibrils is believed to be toxic to beta cells and responsible for beta cell dysfunction and death associated with type 2 diabetes. Insulin has been found to act against the actions of hIAPP. The internal sequence of …
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Protective effect of Nicotinamide on High glucose (HG)/Palmitate (PA)-induced Glucolipotoxicity to INS-1 beta cells
Prolonged exposure of pancreatic beta cells to excessive levels of glucose and fatty acids is postulated to contribute to beta cell dysfunction and beta cell death in type 2 diabetes. Nicotinamide, via its major metabolite NAD+, is involved in a wide range of biological processes, including the …
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Erythropoietin Signaling in Pancreatic Beta Cells in Homeostasis and in Models of Type 1 and Type 2 Diabetes
… exerts cytoprotective effects on non-erythroid cells. However, the in vivo role of EPO on the pancreatic β cells has not been evaluated to date. We hypothesized that EPO would have direct cytoprotective effects on the pancreatic β cells and provide protection against experimental models of …
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Heat shock protein 90, a potential biomarker for type I diabetes: mechanisms of release from pancreatic beta cells
… is known to be associated with various forms of beta cell stress, including endoplasmic reticulum stress, insulitis, and hyperglycemia. Therefore, to test the hypothesis that HSP90 is released by these cells in response to stress, human pancreatic beta cells were subjected to various forms of …
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Studies in beta cells and adipocytes in the context of obesity and T2D - focusing on PDE3B, OPN and SCFAs
… and reduced insulin exocytosis from pancreatic β-cells. Obesity, which dramatically increases worldwide, is associated with insulin resistance and T2D. In this thesis, we elucidate the effects of hormones and nutrients on biological responses and regulatory mechanisms in pancreatic β-cells and …
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Glycemic control and pancreatic beta cells protective effect of a lanosteryl triterpene from Protorhus longifolia in hyperlipidemic and STZ-induced diabetic rats
… further aggravates insult to insulin producing beta cells of the pancreas, thereby worsening the diabetic state. Current treatment regimen for DM comprises self-care and anti-diabetic drugs such as biguanides (metformin), thiazolidinediones and sulfonylureas. Metformin is currently the most …
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New Roles of the Transcription Factor NKX6.1 in Beta Cell Biology
Pancreatic islet beta cells play a critical role in the maintenance of metabolic fuel homeostasis. Type 1 diabetes results from autoimmune destruction of the beta cells, whereas type 2 diabetes involves loss of beta cell function, particularly glucose-stimulated insulin secretion (GSIS), and a …
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Regulation of Exocytosis by Syntaxin 4-Munc18c Complexes
… insulin secretion (GSIS) from the pancreatic beta cells in combination with defects in peripheral (muscle and adipose) tissue glucose uptake. Both GSIS and glucose uptake are regulated by Syntaxin 4 (Syn4)-Munc18c complexes. Importantly, reports link obesity and Type 2 diabetes in humans with …
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Encapsulation as a 3D model for human embryonic stem cell propagation and differentiation
… chronic disease caused by the destruction of the beta cells of the pancreas. Current treatments for are whole pancreas or islet transplantation, which is limited by scarcity of cadaveric pancreata. Therefore, developing a cell replacement therapy with renewable sources of surrogate beta cells is …
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Quantification of gene expression in single cells
… homogeneous cell populations and single cells often give highly divergent results. Cells exhibit varying responsiveness to stimuli and gene expression and they are in many aspects stochastic and unpredictable. We have developed a method to measure gene expression quantitatively in …
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