Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 34 for “"beta cell function"”.
-
Spinophilin Signaling: Impacts on Body Weight, Obesity, and Beta-Cell Function
… (T2D). Obesity-induced T2D is caused by dysfunction of the insulin-producing beta cells of the pancreas. However, mechanisms that promote obesity and the mechanisms by which obesity leads to beta cell dysfunction are not fully known. Spinophilin is a filamentous (F)-actin binding, protein …
-
Molecular Adaptation of Pancreatic Beta-Cell Function During Endoplasmic Reticulum Stress
Pancreatic beta-cells may balance glucose-stimulated insulin synthesis and secretion with the proteasome activity to regulate protein concentrations in the endoplasmic reticulum (ER). During this process, reactive oxygen species (ROS) may originate as byproducts from the oxidative protein folding …
-
Effects of Ca2+, microRNAs, and rosuvastatin on insulin-secreting beta cell function
… of T2D, it is mainly attributed to beta cell function i.e. failure to secrete insulin or reduced beta cell mass. The exocytotic process is crucial for beta cell function and its dysregulation leads to impaired insulin secretion. Therefore, understanding the central mechanisms …
-
Role of the Vitamin D Receptor in Insulin Secretion and Beta Cell Function
… linking VitD status with pancreatic islet function. Therefore, my studies have focused on the role of Vitamin D and VDR in islet biology. Preincubation of isolated mouse and human islets with Vitamin D results in enhanced glucose-stimulated insulin secretion (GSIS). This response is …
-
Estrogen and Serotonin – old dogs, new tricks, Implications for pancreatic beta-cell function
… different receptors on the pancreatic islet cells, for instance G-protein coupled receptors (GPCRs). When activated, these receptors are able to fine-tune islet hormone secretion and regulate overall β-cell function. Estrogen and serotonin are circulating factors that bind to GPCRs. First, we …
-
The Roles of Rap1 in Cancer Metastasis and Pancreatic Islet Beta Cell Function
… understood. Rap1 signals to pathways involved in cell adhesion, migration, and survival, suggesting that Rap1 may promote several processes associated with metastasis. Recent studies in another biological system have demonstrated that the Rap activator proteins, Epac, are important regulators of …
-
Identifying Genes in Pancreatic Beta-Cell Function using a Novel High-Thoughput Cell-Based Screening Assay
… impaired insulin secretion from the pancreatic beta-cells. It is a global epidemic affecting millions of people around the world, bringing serious economic burden to health care systems. Thus, the underlying components of this disorder are under extensive investigation. The interest of my thesis …
-
Investigation of molecular and cellular events associated with beta cell function and elucidation of extracellular RNAs as potential biomarker for diabetes
… mortality. The potential use of replacement beta cells as therapy for diabetes requires an ability to culture such cells while maintaining their functional status. Glucose stimulated insulin secretion (GSIS) is lost in long-term cultured MIN6 heterogeneous cells. MIN6 B1, a clonal sub-line …
-
The effectiveness of GLP-1 analogues compared to DPP-4 inhibitors for beta cell function and diabetes related complications among adults with type 2 diabetes: a systematic review and meta-analysis
Continued loss of beta cell function is responsible for progressive deterioration of plasma glucose control and complications characteristic of type 2 diabetes. Two classes of incretin-based antihyperglycaemic agents, dipeptidyl peptidase-4 (DPP-4) inhibitors and glucagon-like peptide-1(GLP-1) …
-
Diabetes mellitus in Adults - Aspects of Incidence, Autoimmunity and C-peptide
… (diet ± oral hypoglycaemic agents). Beta cell function (glucagon-stimulated Cpeptide)and metabolic control (HbA1c) were followed for 36 months. LADA patients treated with insulin did not demonstrate better preservation of beta cell function but had a better metabolic control compared …
-
Epigallocatechin Gallate in the Regulation of Insulin Secretion
… (T1D) and Type 2 diabetes (T2D), inadequate beta-cell mass and beta-cell dysfunction lead to impaired insulin secretion, and ultimately worsen glycemic control. Green tea has drawn wide attention due to its possible health-promoting properties, including enhancement of beta-cell function. We …
-
Genetic and immunological risk factors of gestational diabetes mellitus
… or first recognition during pregnancy. Impaired beta-cell function and insulin resistance are the hallmarks of GDM. The overall aim of this thesis was to study the genetic and immunological risk factors that increase susceptibility to GDM. First, we investigated whether autoimmunity and genetic …
-
Epidemiology of diabetes in a well defined population in Sweden: the Skaraborg Diabetes Registry
… and is recommended for determination of beta-cell function and need for insulin treatment. The three islet autoantibodies (ICA, GADA, and IA-2A) had equal power to diagnose autoimmune diabetes in children. In adults, one single islet autoantibody was not enough for detecting autoimmune …
-
Novel Roles of Gastrin and Cholecystokinin in Islet Beta Cell Proliferation
… 2 diabetes share a common theme: an insufficient beta cell mass to maintain glucose homeostasis. In Type 1 diabetes this deficiency arises from autoimmune destruction of the beta cells. In the latter stages of Type 2 diabetes, there is a precipitous drop in beta cell mass, resulting from the …
-
Tracing of Alpha-to-Beta Cell Transition Following Treatment with CHIR-Injected Human Multipotent Stromal Cell Secreted Proteins
… manages symptoms but cannot restore endogenous beta cell function. Regenerative strategies have demonstrated beta-cell neogenesis following ablation; however, the cellular mechanisms driving islet regeneration remain unclear. Previous work from the Hess Lab has shown that human bone …
-
Proteomic profiling of skeletal muscle tissue from the Goto-Kakizaki rat model of type 2 diabetes.
… (T2D) are both insulin resistance and impaired beta cell function. Abnormal glucose handling and variable degrees of peripheral insulin resistance characterise T2D. Skeletal muscle is the largest insulin-regulated glucose sink in the body and represents approximately 80% of whole body …
-
Molecular Genetic Analysis of Rodent Non-Insulin Dependent Diabetes Mellitus
… glucose transport, production and pancreatic beta cell function. Due to these complexities, only a small number of the genes, usually in rare sub-types of NIDDM, have been identified in humans. Because inbred rodent strains are inherently more tractable genetically and can be employed in cases …
-
The effect of iron metabolism on palmitate-induced INS-1 cell death
… A. MATERIALS 24 1. Reagents 24 B. METHODS 25 1. Cell Culture 25 2. Preparation of palmitate 25 3. Isolation of islets 25 4. MTT-bases viability assay 26 5. Measurement of cell death 26 6. Western blot analysis 27 7. RNA extraction and microarray analysis 27 8. Reverse transcriptase-polymerase …
-
The Prediabetes Detection and Physical Activity Intervention Delivery (PRE-PAID) Project
… significant improvements in glycemic control, beta cell function, waist circumference and aerobic fitness following 3 months of supervised exercise. This research provides evidence for early detection of persons with prediabetes and strategies for improving glycemic control and physical plus …
-
New Roles of the Transcription Factor NKX6.1 in Beta Cell Biology
Pancreatic islet beta cells play a critical role in the maintenance of metabolic fuel homeostasis. Type 1 diabetes results from autoimmune destruction of the beta cells, whereas type 2 diabetes involves loss of beta cell function, particularly glucose-stimulated insulin secretion (GSIS), and a …
Page 1 of 2