Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"beta catenin"”.
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Beta-catenin Complexes in Colorectal Cancer
… that is disrupted in colorectal cancer and β-catenin is the key mediator of Wnt signalling. β-catenin is a multifunctional protein with roles in Wnt signalling and cell adhesion. I aimed to understand the relationship between the main interactions and functions of β-catenin. Specifically, I …
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Wnt/beta-Catenin-Zielgene in der Mausentwicklung
Der Wnt/beta-Catenin-Signalweg ist an der Steuerung vieler Prozesse während der Embryonalentwicklung beteiligt. Die zentrale Komponente des Signalwegs ist das Protein beta-Catenin, das an LEF/TCF-Transkriptionsfaktoren bindet und so Zielgene des Wnt/beta-Catenin-Signalwegs aktiviert. Ziel dieser …
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Wnt-/beta- Catenin Zielgene der frühen Mausentwicklung
… entwicklungsrelevante Zielgene der Wnt-/b- Catenin- Kaskade identifiziert. <br>Es wurde ein Zellkultursystem etabliert, mit dem es möglich war, unter einfachen experimentellen Bedingungen, die Wnt- Kaskade in Zellen induzieren zu können. Für das benutzte Zellkultursystem aus Embryonalen …
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Beta-Catenin and Development of the Urogenital System
… of the urogenital system, canonical Wnt/beta-catenin signaling is known to play a significant role. To better understand the role Wnt signaling plays in reproductive tract development, we conditionally removed beta-catenin from the Wolffian duct using a HoxB7cre line of mice. We …
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An immunohistochemical study of beta-catenin in HNPCC colon tumours
Beta-catenin is normally complexed with adenomatous polyposis coli (APC) protein and E-cadherin adhesion molecule, and localized on the cell membrane. If APC/beta-catenin is disrupted, beta-catenin transfers into the nucleus, where it functions as a transcriptional activator, causing unregulated …
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Diet-induced-obesity suppresses beta-catenin and promotes cell proliferation during colon development
The student, Guanying Xu, submitted this Thesis for approval on 2018-07-17 at 11:44.
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COMPARATIVE CELL BASED FUNCTIONAL ANALYSIS OF KEY WNT/BETA-CATENIN PATHWAY GENES AND GENE MUTATIONS
The Wnt/Beta-catenin signaling pathway has many roles including regulation of developmental pathways, cell proliferation, and homeostasis of adult tissues. Wnt/Beta-catenin signaling activity depends on the stability and localization of Beta-catenin in the cell. In the absence of a Wnt-signal, …
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Charakterisierung des mit der Alzheimer Krankheit assoziierten Genprodukts Presenilin 1 und Interaktion mit beta-Catenin
… als auch intrazellulär wichtigen Protein bCatenin. Zur Verifizierung der Interaktion wurden die in dieser Arbeit hergestellten Antikörper verwendet. Mit Hilfe von Koimmunpräzipitationsexperimenten ist es gelungen, sowohl die Interaktion zwischen PS1-NTF und PS1-CTF nachzuweisen als auch die …
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The role of beta-catenin in the development of fetal ovary and female germ cells
… the ones that signal via the canonical β-catenin pathway, are expressed in fetal gonads, suggesting their intimate association with β-catenin and potential role in regulating ovary development. Thus, the central hypothesis of my studies is that the canonical β-catenin signaling pathway is …
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New insights into cornea-lens regeneration in Xenopus laevis: the role of Wnt/beta-catenin signaling and the regenerative capacity of the limbal region
… for regeneration, we investigated the Wnt/β-catenin signaling pathway in the context of lens regeneration (Chapter 2) as it has been shown to be important in both embryonic lens development as well as in Wolffian lens regeneration that takes place in newts and salamanders; however, it had not …
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Effects of Binge Alcohol Exposure on Canonical Wnt Signaling During Fracture Repair
… pathway, through tight regulation of stabilized beta-catenin, plays an essential and pivotal role in the formation of new bone and cartilage to initiate bone repair. We sought to determine the molecular mechanisms behind alcohol-related fracture complications by testing the hypothesis that binge …
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Molecular mechanisms of Kruppel-like Factor 4
The Wnt/beta-catenin pathway is a key pathway involved in the regulation of proliferation and differentiation within many tissues, including the epithelium of the intestine and of the skin. Wnt signaling is implicated in stem cell renewal. Deregulation of Wnt/beta-catenin signaling is crucial early …
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Investigating the Non-globular Proteins of the Canonical Wnt Signalling Pathway
… twelve Armadillo (ARM) repeat-containing protein beta-catenin acts as the signal transducer in this pathway and is continuously degraded in the cytosol by the beta-catenin destruction complex (BDC). Upon receiving the Wnt signal the BDC is inactivated, allowing beta-catenin to accumulate in the …
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The transcriptional regulation of skeletal muscle progenitor cell fate
… was further extended by the demonstration that beta-catenin occupies the chromatin upstream of Foxc1 during differentiation. Loss of functional Gli2 and Meox1 led to the downregulation of Foxc1/2, while misexpression of Gli2 upregulated the expression of these two genes. These studies have …
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teashirt is required for head-versus-tail regeneration polarity in planarians
… observed with RNAi of the Wnt pathway genes [beta]-catenin-1, wntl, Dvl-1/2, or wntless. teashirt was required for [beta]-catenin-I-dependent activation of posterior genes during regeneration. These findings identify teashirt as a transcriptional target of Wnt signaling required for …
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The dissemination of oncogenic RasV12-transformed cells in the adult Drosophila intestine
… invasion. We demonstrate that Drosophila E-cad/beta-catenin disassembles at adherens junctions and assembles at invasive protrusions during cell dissemination. Loss of E-cad attenuates dissemination of RasV12-transformed cells by impairing their ability to compromise the ECM. Furthermore, we …
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Interactions between BMP and Canonical Wnt Signaling Regulate Critical Stages of the Osteoblast Lifecycle
… process. Previous work in our lab showed that beta-catenin, an essential mediator of canonical Wnt signaling, synergizes with BMP2 to stimulate osteoblast differentiation and bone formation. My work was designed to conduct a full evaluation of how BMP and Wnt signals interact at discrete stages …
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Feedback Regulation of Wnt Signaling by Naked Cuticle (Nkd) During Drosophila Embryogenesis
Wnt/beta -catenin signals are essential for many developmental and physiological processes in animals. Deregulation of the Wnt signaling pathway in mammals can cause diseases such as birth defects, cancer, osteoporosis, and diabetes. In Drosophila, the naked cuticle (nkd) gene antagonizes the …
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